PDB entry 4nm7

View 4nm7 on RCSB PDB site
Description: Crystal structure of GSK-3/Axin complex bound to phosphorylated Wnt receptor LRP6 e-motif
Class: transferase/peptide
Keywords: Wnt, LRP6, Auto-inhibited, GSK-3, primed substrate, Kinase, Axin, phosphorylated Wnt receptor LRP6 e-motif, TRANSFERASE-PEPTIDE complex
Deposited on 2013-11-14, released 2014-03-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-04-23, with a file datestamp of 2014-04-18.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.185
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: GSK3B protein
    Species: Homo sapiens [TaxId:9606]
    Gene: GSK3B, hCG_1818062
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6FI27 (Start-370)
      • expression tag (371)
    Domains in SCOPe 2.08: d4nm7a1, d4nm7a2
  • Chain 'B':
    Compound: Axin-1
    Species: Homo sapiens [TaxId:9606]
    Gene: AXIN1, AXIN
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Phosphorylated Wnt receptor LRP6 e-motif
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4NM7
  • Heterogens: ADP, GOL, MG, CL, DTT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4nm7A (A:)
sckpvqqpsafgsmkvsrdkdgskvttvvatpgqgpdrpqevsytdtkvigngsfgvvyq
aklcdsgelvaikkvlqdkrfknrelqimrkldhcnivrlryffyssgekkdevylnlvl
dyvpetvyrvarhysrakqtlpviyvklymyqlfrslayihsfgichrdikpqnllldpd
tavlklcdfgsakqlvrgepnvsyicsryyrapelifgatdytssidvwsagcvlaelll
gqpifpgdsgvdqlveiikvlgtptreqiremnpnytefkfpqikahpwtkvfrprtppe
aialcsrlleytptarltpleacahsffdelrdpnvklpngrdtpalfnfttqelssnpp
latilippharhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4nm7A (A:)
smkvsrdskvttvvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkv
lqdkrfknrelqimrkldhcnivrlryffysskkdevylnlvldyvpetvyrvarhysra
kqtlpviyvklymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvr
gepnvsyicsryyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlvei
ikvlgtptreqiremnpnytefkfpqikahpwtkvfrprtppeaialcsrlleytptarl
tpleacahsffdelrdpnvklpngrdtpalfnfttqelssnpplatilippharh

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    No sequence available.