PDB entry 4nkv

View 4nkv on RCSB PDB site
Description: Human steroidogenic cytochrome P450 17A1 mutant A105L with inhibitor abiraterone
Deposited on 2013-11-13, released 2014-10-22
The last revision was dated 2014-12-03, with a file datestamp of 2014-11-28.
Experiment type: XRAY
Resolution: 2.65 Å
R-factor: 0.193
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Steroid 17-alpha-hydroxylase/17,20 lyase
    Species: Homo sapiens [TaxId:9606]
    Gene: CYP17, CYP17A1, CYPc17, S17AH
    Database cross-references and differences (RAF-indexed):
    • Uniprot P05093
      • engineered mutation (86)
  • Chain 'B':
    Compound: Steroid 17-alpha-hydroxylase/17,20 lyase
    Species: Homo sapiens [TaxId:9606]
    Gene: CYP17, CYP17A1, CYPc17, S17AH
    Database cross-references and differences (RAF-indexed):
    • Uniprot P05093
      • engineered mutation (86)
  • Chain 'C':
    Compound: Steroid 17-alpha-hydroxylase/17,20 lyase
    Species: Homo sapiens [TaxId:9606]
    Gene: CYP17, CYP17A1, CYPc17, S17AH
    Database cross-references and differences (RAF-indexed):
    • Uniprot P05093
      • engineered mutation (86)
  • Chain 'D':
    Compound: Steroid 17-alpha-hydroxylase/17,20 lyase
    Species: Homo sapiens [TaxId:9606]
    Gene: CYP17, CYP17A1, CYPc17, S17AH
    Database cross-references and differences (RAF-indexed):
    • Uniprot P05093
      • engineered mutation (86)
  • Heterogens: HEM, AER, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >4nkvA (A:)
makktgakypksllslplvgslpflprhghmhnnffklqkkygpiysvrmgtkttvivgh
hqlakevlikkgkdfsgrpqmatldilsnnrkgiafadsgahwqlhrrlamatfalfkdg
dqklekiicqeistlcdmlathngqsidisfpvfvavtnvislicfntsykngdpelnvi
qnynegiidnlskdslvdlvpwlkifpnktleklkshvkirndllnkilenykekfrsds
itnmldtlmqakmnsdngnagpdqdsellsdnhilttigdifgagvetttsvvkwtlafl
lhnpqvkkklyeeidqnvgfsrtptisdrnrlllleatirevlrlrpvapmliphkanvd
ssigefavdkgteviinlwalhhnekewhqpdqfmperflnpagtqlispsvsylpfgag
prscigeilarqelflimawllqrfdlevpddgqlpslegipkvvflidsfkvkikvrqa
wreaqaegsthhhh

    Sequence, based on observed residues (ATOM records):
    >4nkvA (A:)
llslplvgslpflprhghmhnnffklqkkygpiysvrmgtkttvivghhqlakevlikkg
kdfsgrpqmatldilsnnrkgiafadsgahwqlhrrlamatfalfkdgdqklekiicqei
stlcdmlathngqsidisfpvfvavtnvislicfntsykngdpelnviqnynegiidnls
kdslvdlvpwlkifpnktleklkshvkirndllnkilenykekfrsdsitnmldtlmqak
mnsdqdsellsdnhilttigdifgagvetttsvvkwtlafllhnpqvkkklyeeidqnvg
fsrtptisdrnrlllleatirevlrlrpvapmliphkanvdssigefavdkgteviinlw
alhhnekewhqpdqfmperflnpagtqlispsvsylpfgagprscigeilarqelflima
wllqrfdlevpddgqlpslegipkvvflidsfkvkikvrqawreaq

  • Chain 'B':
    Sequence, based on SEQRES records:
    >4nkvB (B:)
makktgakypksllslplvgslpflprhghmhnnffklqkkygpiysvrmgtkttvivgh
hqlakevlikkgkdfsgrpqmatldilsnnrkgiafadsgahwqlhrrlamatfalfkdg
dqklekiicqeistlcdmlathngqsidisfpvfvavtnvislicfntsykngdpelnvi
qnynegiidnlskdslvdlvpwlkifpnktleklkshvkirndllnkilenykekfrsds
itnmldtlmqakmnsdngnagpdqdsellsdnhilttigdifgagvetttsvvkwtlafl
lhnpqvkkklyeeidqnvgfsrtptisdrnrlllleatirevlrlrpvapmliphkanvd
ssigefavdkgteviinlwalhhnekewhqpdqfmperflnpagtqlispsvsylpfgag
prscigeilarqelflimawllqrfdlevpddgqlpslegipkvvflidsfkvkikvrqa
wreaqaegsthhhh

    Sequence, based on observed residues (ATOM records):
    >4nkvB (B:)
sllslplvgslpflprhghmhnnffklqkkygpiysvrmgtkttvivghhqlakevlikk
gkdfsgrpqmatldilsnnrkgiafadsgahwqlhrrlamatfalfkdgdqklekiicqe
istlcdmlathngqsidisfpvfvavtnvislicfntsykngdpelnviqnynegiidnl
skdslvdlvpwlkifpnktleklkshvkirndllnkilenykekfrsdsitnmldtlmqa
kmnsdndsellsdnhilttigdifgagvetttsvvkwtlafllhnpqvkkklyeeidqnv
gfsrtptisdrnrlllleatirevlrlrpvapmliphkanvdssigefavdkgteviinl
walhhnekewhqpdqfmperflnpagtqlispsvsylpfgagprscigeilarqelflim
awllqrfdlevpddgqlpslegipkvvflidsfkvkikvrqawreaq

  • Chain 'C':
    Sequence, based on SEQRES records:
    >4nkvC (C:)
makktgakypksllslplvgslpflprhghmhnnffklqkkygpiysvrmgtkttvivgh
hqlakevlikkgkdfsgrpqmatldilsnnrkgiafadsgahwqlhrrlamatfalfkdg
dqklekiicqeistlcdmlathngqsidisfpvfvavtnvislicfntsykngdpelnvi
qnynegiidnlskdslvdlvpwlkifpnktleklkshvkirndllnkilenykekfrsds
itnmldtlmqakmnsdngnagpdqdsellsdnhilttigdifgagvetttsvvkwtlafl
lhnpqvkkklyeeidqnvgfsrtptisdrnrlllleatirevlrlrpvapmliphkanvd
ssigefavdkgteviinlwalhhnekewhqpdqfmperflnpagtqlispsvsylpfgag
prscigeilarqelflimawllqrfdlevpddgqlpslegipkvvflidsfkvkikvrqa
wreaqaegsthhhh

    Sequence, based on observed residues (ATOM records):
    >4nkvC (C:)
llslplvgslpflprhghmhnnffklqkkygpiysvrmgtkttvivghhqlakevlikkg
kdfsgrpqmatldilsnnrkgiafadsgahwqlhrrlamatfalfkdgdqklekiicqei
stlcdmlathngqsidisfpvfvavtnvislicfntsykngdpelnviqnynegiidnls
kdslvdlvpwlkifpnktleklkshvkirndllnkilenykekfrsdsitnmldtlmqak
mnsdnggpdqdsellsdnhilttigdifgagvetttsvvkwtlafllhnpqvkkklyeei
dqnvgfsrtptisdrnrlllleatirevlrlrpvapmliphkanvdssigefavdkgtev
iinlwalhhnekewhqpdqfmperflnpagtqlispsvsylpfgagprscigeilarqel
flimawllqrfdlevpddgqlpslegipkvvflidsfkvkikvrqawreaq

  • Chain 'D':
    Sequence, based on SEQRES records:
    >4nkvD (D:)
makktgakypksllslplvgslpflprhghmhnnffklqkkygpiysvrmgtkttvivgh
hqlakevlikkgkdfsgrpqmatldilsnnrkgiafadsgahwqlhrrlamatfalfkdg
dqklekiicqeistlcdmlathngqsidisfpvfvavtnvislicfntsykngdpelnvi
qnynegiidnlskdslvdlvpwlkifpnktleklkshvkirndllnkilenykekfrsds
itnmldtlmqakmnsdngnagpdqdsellsdnhilttigdifgagvetttsvvkwtlafl
lhnpqvkkklyeeidqnvgfsrtptisdrnrlllleatirevlrlrpvapmliphkanvd
ssigefavdkgteviinlwalhhnekewhqpdqfmperflnpagtqlispsvsylpfgag
prscigeilarqelflimawllqrfdlevpddgqlpslegipkvvflidsfkvkikvrqa
wreaqaegsthhhh

    Sequence, based on observed residues (ATOM records):
    >4nkvD (D:)
sllslplvgslpflprhghmhnnffklqkkygpiysvrmgtkttvivghhqlakevlikk
gkdfsgrpqmatldilsnnrkgiafadsgahwqlhrrlamatfalfkdgdqklekiicqe
istlcdmlathngqsidisfpvfvavtnvislicfntsykngdpelnviqnynegiidnl
skdslvdlvpwlkifpnktleklkshvkirndllnkilenykekfrsdsitnmldtlmqa
kmnsddsellsdnhilttigdifgagvetttsvvkwtlafllhnpqvkkklyeeidqnvg
fsrtptisdrnrlllleatirevlrlrpvapmliphkanvdssigefavdkgteviinlw
alhhnekewhqpdqfmperflnpagtqlispsvsylpfgagprscigeilarqelflima
wllqrfdlevpddgqlpslegipkvvflidsfkvkikvrqawreaq