PDB entry 4nkq

View 4nkq on RCSB PDB site
Description: Structure of a Cytokine Receptor Complex
Class: cytokine/cytokine receptor
Keywords: GM-CSF, receptor complex, dodecamer, Disease mutation, Glycoprotein, Membrane, Phosphoprotein, Transmembrane, Cytokine, Growth factor, Secreted, CYTOKINE-CYTOKINE RECEPTOR complex
Deposited on 2013-11-13, released 2015-09-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 3.3 Å
R-factor: N/A
AEROSPACI score: 0.1 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cytokine receptor common subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: CSF2RB, IL3RB, IL5RB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P32927 (0-End)
      • engineered mutation (321)
  • Chain 'B':
    Compound: Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: CSF2RA, CSF2R, CSF2RY
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4nkqb1, d4nkqb2
  • Chain 'C':
    Compound: granulocyte-macrophage colony-stimulating factor
    Species: Homo sapiens [TaxId:9606]
    Gene: CSF2, GMCSF
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4nkqc1, d4nkqc2
  • Heterogens: NAG

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4nkqB (B:)
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nskrrreircpyyiqdsgthvgchldnlsgltsrnyflvngtsreigiqffdslldtkki
erfnppsnvtvrcntthclvrwkqprtyqklsyldfqyqldvhrkntqpgtenllinvsg
dlenrynfpsseprakhsvkiraadvrilnwsswseaiefgsddgnlgsvyiyvllivgt
lvcgivlgflfkrflriqrlfppvpqikdklndnhevedeiiweeftpeegkgyreevlt
vkeit

    Sequence, based on observed residues (ATOM records): (download) 
    >4nkqB (B:)
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qdsgthvgchldnlsgltsrnyfslldtkkierfnppsnvtvrcntthclvrwkqprtyq
klsyldfqyqldvhrkntqpgtenllinvsgdlenrynfpsseprakhsvkiraadvril
nwsswseaief

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4nkqC (C:)
aparspspstqpwehvnaiqearrllnlsrdtaaemnetvevisemfdlqeptclqtrle
lykqglrgsltklkgpltmmashykqhcpptpetscatqiitfesfkenlkdfllvipfd
cwepvqe

    Sequence, based on observed residues (ATOM records): (download) 
    >4nkqC (C:)
ehvnaiqearrllnlsrdtaaemnetvevisemfdlqeptclqtrlelykqglrgsltkl
kgpltmmashykqhcpptpetscatqiitfesfkenlkdfllvip