PDB entry 4nkk
View 4nkk on RCSB PDB site
Description: Crystal structure of a multi-drug resistant clinical isolate-769 HIV-1 protease variant that is resistant to the dimerization inhibitory activity of TLF-PafF
Class: hydrolase
Keywords: HIV, AIDS, HIV-1 protease, dimerization inhibitors, protease inhibitors, multidrug-resistance, clinical isolate 769, dimer protease, Hydrolase
Deposited on
2013-11-12, released
2014-07-09
The last revision prior to the SCOPe 2.08 freeze date was dated
2014-08-20, with a file datestamp of
2014-08-15.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.206
AEROSPACI score: 0.41
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: hiv-1 protease
Species: Human immunodeficiency virus 1 [TaxId:11676]
Gene: pol
Database cross-references and differences (RAF-indexed):
- Uniprot Q000H7 (0-98)
- engineered mutation (9)
- engineered mutation (24)
- see remark 999 (34-35)
- see remark 999 (45)
- see remark 999 (81)
Domains in SCOPe 2.08: d4nkka_ - Heterogens: HOH