PDB entry 4nke

View 4nke on RCSB PDB site
Description: The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
Class: transferase
Keywords: Alpha-Helical Prenyltransferase, Isoprene Biosynthesis, Lipid Synthesis, Steroid Biosynthesis, Transferase, Isoprenoid Pathway, Cholesterol Synthesis, Bisphosphonates
Deposited on 2013-11-12, released 2014-11-19
The last revision prior to the SCOPe 2.06 freeze date was dated 2014-11-19, with a file datestamp of 2014-11-14.
Experiment type: XRAY
Resolution: 1.46 Å
R-factor: 0.181
AEROSPACI score: 0.58 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: farnesyl pyrophosphate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: FDPS, FPS, KIAA1293
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14324
      • conflict (74)
      • engineered mutation (260)
    Domains in SCOPe 2.06: d4nkea_
  • Heterogens: MG, RIS, IPE, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4nkeA (A:)
mgsshhhhhhssgrenlyfqghmngdqnsdvyaqekqdfvqhfsqivrvltedemghpei
gdaiarlkevleyntiggkynrgltvvvafrelveprkqdadslqrawtvgwcvellqaf
flvaddimdssltrrgqicwyqkpgvgldaindanlleaciyrllklycreqpyylnlie
lflqssyqteigqtldlltapqgnvdlvrftekryksivkyktafysfylpiaaamymag
idgekehanakkillemgefaqiqddyldlfgdpsvtgkigtdiqdnkcswlvvqclqra
tpeqyqilkenygqkeaekvarvkalyeeldlpavflqyeedsyshimalieqyaaplpp
avflglarkiykrrk

    Sequence, based on observed residues (ATOM records): (download) 
    >4nkeA (A:)
vyaqekqdfvqhfsqivrvltehpeigdaiarlkevleyntiggkynrgltvvvafrelv
eprkqdadslqrawtvgwcvellqafflvaddimdssltrrgqicwyqkpgvgldainda
nlleaciyrllklycreqpyylnlielflqssyqteigqtldlltapqgnvdlvrftekr
yksivkyktafysfylpiaaamymagidgekehanakkillemgefaqiqddyldlfgdp
svtgkigtdiqdnkcswlvvqclqratpeqyqilkenygqkeaekvarvkalyeeldlpa
vflqyeedsyshimalieqyaaplppavflglarkiyk