PDB entry 4nj3

View 4nj3 on RCSB PDB site
Description: Modulating the interaction between CDK2 and Cyclin A with a Quinoline-based inhibitor
Class: transferase/transferase inhibitor
Keywords: CELL CYCLE, INHIBITION, CYCLIN-DEPENDENT KINASE, CANCER, ATP-BINDING, CELL DIVISION,MITOSIS, NUCLEOTIDE-BINDING, PHOSPHORYLATION, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, transferase-transferase inhibitor complex
Deposited on 2013-11-08, released 2013-11-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-01-08, with a file datestamp of 2014-01-03.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: 0.184
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cyclin-dependent kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: CDK2, CDKN2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4nj3a_
  • Heterogens: 2KD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4nj3A (A:)
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

    Sequence, based on observed residues (ATOM records): (download) 
    >4nj3A (A:)
menfqkvekigegtygvvykarnkltgevvalkkirldpstaireisllkelnhpnivkl
ldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchshrvlhr
dlkpqnllintegaikladfglarevvtlwyrapeillgckyystavdiwslgcifaemv
trralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpkwarqdfskvvpplde
dgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl