PDB entry 4nif

View 4nif on RCSB PDB site
Description: Heterodimeric structure of ERK2 and RSK1
Class: transferase
Keywords: Kinase domain, SIGNALING, Substrate kinase binding, TRANSFERASE
Deposited on 2013-11-06, released 2014-11-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-03-25, with a file datestamp of 2015-03-20.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ribosomal protein S6 kinase alpha-1
    Species: Homo sapiens [TaxId:9606]
    Gene: RPS6KA1, MAPKAPK1A, RSK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4nifa_
  • Chain 'B':
    Compound: Mitogen-activated protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPK1, ERK2, PRKM1, PRKM2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4nifb_
  • Chain 'D':
    Compound: Ribosomal protein S6 kinase alpha-1
    Species: Homo sapiens [TaxId:9606]
    Gene: RPS6KA1, MAPKAPK1A, RSK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4nifd_
  • Chain 'E':
    Compound: Mitogen-activated protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPK1, ERK2, PRKM1, PRKM2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4nife_
  • Heterogens: ANP, SO4, NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4nifA (A:)
gsnlvfsdgyvvketigvgsyseckrcvhkatnmeyavkvidkskrdpseeieillrygq
hpniitlkdvyddgkhvylvtelmrggelldkilrqkffsereasfvlhtigktveylhs
qgvvhrdlkpsnilyvdesgnpeclricdfgfakqlraengllmtpcytanfvapevlkr
qgydegcdiwslgillytmlagytpfangpsdtpeeiltrigsgkftlsggnwntvseta
kdlvskmlhvdphqrltakqvlqhpwvtqkdklpqsqlshqdlqlvkgamaatysalnss
kptpqlkpiessilaqrrvrklpsttlhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4nifA (A:)
vfsdgyvvketigvgsyseckrcvhkatnmeyavkvidkskrdpseeieillrygqhpni
itlkdvyddgkhvylvtelmrggelldkilrqkffsereasfvlhtigktveylhsqgvv
hrdlkpsnilyvdesgnpeclricdfgfakqlraengllmtpcyfvapevlkrqgydegc
diwslgillytmlagytpfangpsdtpeeiltrigsgkftlsggnwntvsetakdlvskm
lhvdphqrltakqvlqhpwvtqkdklpqsqlshqdlqlvkgamaatysalnsskptpqlk
piessilaqrrvr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4nifB (B:)
gsmaaaaaagagpemvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkisp
fehqtycqrtlreikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllkt
qhlsndhicyflyqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdh
dhtgflteyvatrwyrapeimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqln
hilgilgspsqedlnciinlkarnyllslphknkvpwnrlfpnadskaldlldkmltfnp
hkrieveqalahpyleqyydpsdepiaeapfkfdmelddlpkeklkelifeetarfqpgy
rs

    Sequence, based on observed residues (ATOM records): (download) 
    >4nifB (B:)
agpemvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqtycqrt
lreikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicy
flyqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhgflteyvatr
wyrapeimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqed
lnciinlkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalahp
yleqyydpsdepiaeapfkfdmelddlpkeklkelifeetarfqpgyrs

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4nifD (D:)
gsnlvfsdgyvvketigvgsyseckrcvhkatnmeyavkvidkskrdpseeieillrygq
hpniitlkdvyddgkhvylvtelmrggelldkilrqkffsereasfvlhtigktveylhs
qgvvhrdlkpsnilyvdesgnpeclricdfgfakqlraengllmtpcytanfvapevlkr
qgydegcdiwslgillytmlagytpfangpsdtpeeiltrigsgkftlsggnwntvseta
kdlvskmlhvdphqrltakqvlqhpwvtqkdklpqsqlshqdlqlvkgamaatysalnss
kptpqlkpiessilaqrrvrklpsttlhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4nifD (D:)
vfsdgyvvketigvgsyseckrcvhkatnmeyavkvidkskrdpseeieillrygqhpni
itlkdvyddgkhvylvtelmrggelldkilrqkffsereasfvlhtigktveylhsqgvv
hrdlkpsnilyvdesgnpeclricdfgfakqlraengllmtpcnfvapevlkrqgydegc
diwslgillytmlagytpfangpsdtpeeiltrigsgkftlsggnwntvsetakdlvskm
lhvdphqrltakqvlqhpwvtqkdklpqsqlshqdlqlvkgamaatysalnsskptpqlk
piessilaqrrvr

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4nifE (E:)
gsmaaaaaagagpemvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkisp
fehqtycqrtlreikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllkt
qhlsndhicyflyqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdh
dhtgflteyvatrwyrapeimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqln
hilgilgspsqedlnciinlkarnyllslphknkvpwnrlfpnadskaldlldkmltfnp
hkrieveqalahpyleqyydpsdepiaeapfkfdmelddlpkeklkelifeetarfqpgy
rs

    Sequence, based on observed residues (ATOM records): (download) 
    >4nifE (E:)
gpemvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqtycqrtl
reikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyf
lyqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhgflteyvatrw
yrapeimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqedl
nciinlkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalahpy
leqyydpsdepiaeapfkfdmelddlpkeklkelifeetarfqpgyrs