PDB entry 4nfr

View 4nfr on RCSB PDB site
Description: Human brain aspartoacylase mutant E285A complex with intermediate analog (N-phosphonomethyl-L-aspartate)
Class: hydrolase
Keywords: Canavan disease, N-acetyl-L-aspartate, Zinc-dependent hydrolase, aspartoacylase family, aminoacylase-2, HYDROLASE
Deposited on 2013-10-31, released 2014-07-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-15, with a file datestamp of 2017-11-10.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Aspartoacylase
    Species: Homo sapiens [TaxId:9606]
    Gene: ACY2, ASP, ASPA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P45381
      • engineered mutation (284)
    Domains in SCOPe 2.08: d4nfra_
  • Chain 'B':
    Compound: Aspartoacylase
    Species: Homo sapiens [TaxId:9606]
    Gene: ACY2, ASP, ASPA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P45381
      • engineered mutation (284)
    Domains in SCOPe 2.08: d4nfrb_
  • Heterogens: AS9, ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4nfrA (A:)
mtschiaeehiqkvaifggthgneltgvflvkhwlengaeiqrtglevkpfitnpravkk
ctryidcdlnrifdlenlgkkmsedlpyevrraqeinhlfgpkdsedsydiifdlhntts
nmgctliledsrnnfliqmfhyiktslaplpcyvyliehpslkyattrsiakypvgievg
pqpqgvlradildqmrkmikhaldfihhfnegkefppcaievykiiekvdyprdengeia
aiihpnlqdqdwkplhpgdpmfltldgktiplggdctvypvfvnaaayyekkeafakttk
ltlnaksircclh

    Sequence, based on observed residues (ATOM records): (download) 
    >4nfrA (A:)
hiqkvaifggthgneltgvflvkhwlengaeiqrtglevkpfitnpravkkctryidcdl
nrifdlenlgkkmsedlpyevrraqeinhlfgpkdsedsydiifdlhnttsnmgctlile
dsrnnfliqmfhyiktslaplpcyvyliehpslkyattrsiakypvgievgpqpqgvlra
dildqmrkmikhaldfihhfnegkefppcaievykiiekvdyprdengeiaaiihpnlqd
qdwkplhpgdpmfltldgktiplggdctvypvfvnaaayyekkeafakttkltlnaksir
c

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4nfrB (B:)
mtschiaeehiqkvaifggthgneltgvflvkhwlengaeiqrtglevkpfitnpravkk
ctryidcdlnrifdlenlgkkmsedlpyevrraqeinhlfgpkdsedsydiifdlhntts
nmgctliledsrnnfliqmfhyiktslaplpcyvyliehpslkyattrsiakypvgievg
pqpqgvlradildqmrkmikhaldfihhfnegkefppcaievykiiekvdyprdengeia
aiihpnlqdqdwkplhpgdpmfltldgktiplggdctvypvfvnaaayyekkeafakttk
ltlnaksircclh

    Sequence, based on observed residues (ATOM records): (download) 
    >4nfrB (B:)
hiqkvaifggthgneltgvflvkhwlengaeiqrtglevkpfitnpravkkctryidcdl
nrifdlenlgkkmsedlpyevrraqeinhlfgpkdsedsydiifdlhnttsnmgctlile
dsrnnfliqmfhyiktslaplpcyvyliehpslkyattrsiakypvgievgpqpqgvlra
dildqmrkmikhaldfihhfnegkefppcaievykiiekvdyprdengeiaaiihpnlqd
qdwkplhpgdpmfltldgktiplggdctvypvfvnaaayyekkeafakttkltlnaksir
c