PDB entry 4ne9

View 4ne9 on RCSB PDB site
Description: PCSK9 in complex with LDLR peptide
Class: hydrolase
Keywords: pcsk9, ldl receptor, autocatalytic cleavage, cholesterol metabolism, hydrolase
Deposited on 2013-10-28, released 2014-09-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Proprotein convertase subtilisin/kexin type 9
    Species: Homo sapiens [TaxId:9606]
    Gene: PCSK9, NARC1, PSEC0052
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8NBP7 (0-End)
      • engineered mutation (321)
    Domains in SCOPe 2.08: d4ne9a1, d4ne9a2
  • Chain 'B':
    Compound: Proprotein convertase subtilisin/kexin type 9
    Species: Homo sapiens [TaxId:9606]
    Gene: PCSK9, NARC1, PSEC0052
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8NBP7 (0-End)
      • engineered mutation (321)
    Domains in SCOPe 2.08: d4ne9b1, d4ne9b2
  • Chain 'C':
    Compound: Proprotein convertase subtilisin/kexin type 9
    Species: Homo sapiens [TaxId:9606]
    Gene: PCSK9, NARC1, PSEC0052
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: low-density lipoprotein receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: LDLR
    Database cross-references and differences (RAF-indexed):
  • Chain 'P':
    Compound: Proprotein convertase subtilisin/kexin type 9
    Species: Homo sapiens [TaxId:9606]
    Gene: PCSK9, NARC1, PSEC0052
    Database cross-references and differences (RAF-indexed):
  • Heterogens: NAG, CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4ne9A (A:)
sipwnleritppryradeyqppdggslvevylldtsiqsdhreiegrvmvtdfenvpeed
gtrfhrqaskcdshgthlagvvsgrdagvakgasmrslrvlncqgkgtvsgtliglefir
ksqlvqpvgplvvllplaggysrvlnaacqrlaragvvlvtaagnfrddaclyspasape
vitvgatnaqdqpvtlgtlgtnfgrcvdlfapgediigassdcstcfvsqsgtsqaaahv
agiaammlsaepeltlaelrqrlihfsakdvineawfpedqrvltpnlvaalppsthgag
wqlfcrtvwsahsgptrmataiarcapdeellscssfsrsgkrrgermeaqggklvcrah
nafggegvyaiarccllpqancsvhtappaeasmgtrvhchqqghvltgcsshwevedlg
thkppvlrprgqpnqcvghreasihascchapgleckvkehgipapqeqvtvaceegwtl
tgcsalpgtshvlgayavdntcvvrsrdvsttgstseeavtavaiccrsrhlaqasqelq

    Sequence, based on observed residues (ATOM records): (download) 
    >4ne9A (A:)
sipwnleritppryraslvevylldtsiqsdhreiegrvmvtdfenvpeedgtrfhrqas
kcdshgthlagvvsgrdagvakgasmrslrvlncqgkgtvsgtliglefirksqlvqpvg
plvvllplaggysrvlnaacqrlaragvvlvtaagnfrddaclyspasapevitvgatna
qdqpvtlgtlgtnfgrcvdlfapgediigassdcstcfvsqsgtsqaaahvagiaammls
aepeltlaelrqrlihfsakdvineawfpedqrvltpnlvaalppqlfcrtvwsahsgpt
rmataiarcapdeellscssfsrsgkrrgermeaqggklvcrahnafggegvyaiarccl
lpqancsvhtappaeasmgtrvhchqqghvltgcsshwevedlgpnqcvghreasihasc
chapgleckvkehgipapqeqvtvaceegwtltgcsalpgtshvlgayavdntcvvrsra
vtavaiccrsr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4ne9B (B:)
sipwnleritppryradeyqppdggslvevylldtsiqsdhreiegrvmvtdfenvpeed
gtrfhrqaskcdshgthlagvvsgrdagvakgasmrslrvlncqgkgtvsgtliglefir
ksqlvqpvgplvvllplaggysrvlnaacqrlaragvvlvtaagnfrddaclyspasape
vitvgatnaqdqpvtlgtlgtnfgrcvdlfapgediigassdcstcfvsqsgtsqaaahv
agiaammlsaepeltlaelrqrlihfsakdvineawfpedqrvltpnlvaalppsthgag
wqlfcrtvwsahsgptrmataiarcapdeellscssfsrsgkrrgermeaqggklvcrah
nafggegvyaiarccllpqancsvhtappaeasmgtrvhchqqghvltgcsshwevedlg
thkppvlrprgqpnqcvghreasihascchapgleckvkehgipapqeqvtvaceegwtl
tgcsalpgtshvlgayavdntcvvrsrdvsttgstseeavtavaiccrsrhlaqasqelq

    Sequence, based on observed residues (ATOM records): (download) 
    >4ne9B (B:)
sipwnleritppryraggslvevylldtsiqsdhreiegrvmvtdfenvpeedqaskcds
hgthlagvvsgrdagvakgasmrslrvlncqgkgtvsgtliglefirksqlvqpvgplvv
llplaggysrvlnaacqrlaragvvlvtaagnfrddaclyspasapevitvgatnaqdqp
vtlgtlgtnfgrcvdlfapgediigassdcstcfvsqsgtsqaaahvagiaammlsaepe
ltlaelrqrlihfsakdvineawfpedqrvltpnlvaalppsthqlfcrtvwsahsgptr
mataiarcapdeellscssfsrsgkrrgermeaqggklvcrahnafggegvyaiarccll
pqancsvhtappaeasmgtrvhchqqghvltgcsshwevedlgpnqcvghreasihascc
hapgleckvkehgipapqeqvtvaceegwtltgcsalpgtshvlgayavdntcvvrsrav
tavaiccrsr

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.

  • Chain 'P':
    No sequence available.