PDB entry 4ndn

View 4ndn on RCSB PDB site
Description: Structural insights of MAT enzymes: MATa2b complexed with SAM and PPNP
Class: transferase
Keywords: S-adenosylmethionine (SAMe) synthesis, TRANSFERASE
Deposited on 2013-10-27, released 2014-07-16
The last revision prior to the SCOPe 2.05 freeze date was dated 2014-09-24, with a file datestamp of 2014-09-19.
Experiment type: XRAY
Resolution: 2.34 Å
R-factor: 0.213
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: S-adenosylmethionine synthase isoform type-2
    Species: Homo sapiens [TaxId:9606]
    Gene: MAT2A, AMS2, MATA2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4ndna1, d4ndna2, d4ndna3
  • Chain 'B':
    Compound: S-adenosylmethionine synthase isoform type-2
    Species: Homo sapiens [TaxId:9606]
    Gene: MAT2A, AMS2, MATA2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4ndnb1, d4ndnb2, d4ndnb3
  • Chain 'C':
    Compound: S-adenosylmethionine synthase isoform type-2
    Species: Homo sapiens [TaxId:9606]
    Gene: MAT2A, AMS2, MATA2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4ndnc1, d4ndnc2, d4ndnc3
  • Chain 'D':
    Compound: S-adenosylmethionine synthase isoform type-2
    Species: Homo sapiens [TaxId:9606]
    Gene: MAT2A, AMS2, MATA2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4ndnd1, d4ndnd2, d4ndnd3
  • Chain 'E':
    Compound: methionine adenosyltransferase 2 subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: MAT2B, TGR, MSTP045, Nbla02999, UNQ2435/PRO4995
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4ndne_
  • Chain 'F':
    Compound: methionine adenosyltransferase 2 subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: MAT2B, TGR, MSTP045, Nbla02999, UNQ2435/PRO4995
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4ndnf_
  • Heterogens: MG, EDO, PPK, SAM, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4ndnA (A:)
    mngqlngfheafieegtflftsesvgeghpdkicdqisdavldahlqqdpdakvacetva
    ktgmillageitsraavdyqkvvreavkhigyddsskgfdyktcnvlvaleqqspdiaqg
    vhldrneedigagdqglmfgyatdeteecmpltivlahklnaklaelrrngtlpwlrpds
    ktqvtvqymqdrgavlpirvhtivisvqhdeevcldemrdalkekvikavvpakyldedt
    iyhlqpsgrfviggpqgdagltgrkiivdtyggwgahgggafsgkdytkvdrsaayaarw
    vakslvkgglcrrvlvqvsyaigvshplsisifhygtsqkserelleivkknfdlrpgvi
    vrdldlkkpiyqrtaayghfgrdsfpwevpkklky
    

    Sequence, based on observed residues (ATOM records): (download)
    >4ndnA (A:)
    egtflftsesvgeghpdkicdqisdavldahlqqdpdakvacetvaktgmillageitsr
    aavdyqkvvreavkhigyddsskgfdyktcnvlvaleqqspqglmfgyatdeteecmplt
    ivlahklnaklaelrrngtlpwlrpdsktqvtvqymqdrgavlpirvhtivisvqhdeev
    cldemrdalkekvikavvpakyldedtiyhlqpsgrfviggpqgdagltgrkiivdtygg
    wgahgggafsgkdytkvdrsaayaarwvakslvkgglcrrvlvqvsyaigvshplsisif
    hygtsqkserelleivkknfdlrpgvivrdldlkkpiyqrtaayghfgrdsfpwevpkkl
    ky
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4ndnB (B:)
    mngqlngfheafieegtflftsesvgeghpdkicdqisdavldahlqqdpdakvacetva
    ktgmillageitsraavdyqkvvreavkhigyddsskgfdyktcnvlvaleqqspdiaqg
    vhldrneedigagdqglmfgyatdeteecmpltivlahklnaklaelrrngtlpwlrpds
    ktqvtvqymqdrgavlpirvhtivisvqhdeevcldemrdalkekvikavvpakyldedt
    iyhlqpsgrfviggpqgdagltgrkiivdtyggwgahgggafsgkdytkvdrsaayaarw
    vakslvkgglcrrvlvqvsyaigvshplsisifhygtsqkserelleivkknfdlrpgvi
    vrdldlkkpiyqrtaayghfgrdsfpwevpkklky
    

    Sequence, based on observed residues (ATOM records): (download)
    >4ndnB (B:)
    ieegtflftsesvgeghpdkicdqisdavldahlqqdpdakvacetvaktgmillageit
    sraavdyqkvvreavkhigyddsskgfdyktcnvlvaleqqspdiaqgvhldrneediga
    gdqglmfgyatdeteecmpltivlahklnaklaelrrngtlpwlrpdsktqvtvqymqdr
    gavlpirvhtivisvqhdeevcldemrdalkekvikavvpakyldedtiyhlqpsgrfvi
    ggpqgdagltgrkiivdtyggwgahgggafsgkdytkvdrsaayaarwvakslvkgglcr
    rvlvqvsyaigvshplsisifhygtsqkserelleivkknfdlrpgvivrdldlkkpiyq
    rtaayghfgrdsfpwevpkklky
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >4ndnC (C:)
    mngqlngfheafieegtflftsesvgeghpdkicdqisdavldahlqqdpdakvacetva
    ktgmillageitsraavdyqkvvreavkhigyddsskgfdyktcnvlvaleqqspdiaqg
    vhldrneedigagdqglmfgyatdeteecmpltivlahklnaklaelrrngtlpwlrpds
    ktqvtvqymqdrgavlpirvhtivisvqhdeevcldemrdalkekvikavvpakyldedt
    iyhlqpsgrfviggpqgdagltgrkiivdtyggwgahgggafsgkdytkvdrsaayaarw
    vakslvkgglcrrvlvqvsyaigvshplsisifhygtsqkserelleivkknfdlrpgvi
    vrdldlkkpiyqrtaayghfgrdsfpwevpkklky
    

    Sequence, based on observed residues (ATOM records): (download)
    >4ndnC (C:)
    egtflftsesvgeghpdkicdqisdavldahlqqdpdakvacetvaktgmillageitsr
    aavdyqkvvreavkhigyddsskgfdyktcnvlvaleqqqglmfgyatdeteecmpltiv
    lahklnaklaelrrngtlpwlrpdsktqvtvqymqdrgavlpirvhtivisvqhdeevcl
    demrdalkekvikavvpakyldedtiyhlqpsgrfviggpqgdagltgrkiivdtyggwg
    ahgggafsgkdytkvdrsaayaarwvakslvkgglcrrvlvqvsyaigvshplsisifhy
    gtsqkserelleivkknfdlrpgvivrdldlkkpiyqrtaayghfgrdsfpwevpkklky
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >4ndnD (D:)
    mngqlngfheafieegtflftsesvgeghpdkicdqisdavldahlqqdpdakvacetva
    ktgmillageitsraavdyqkvvreavkhigyddsskgfdyktcnvlvaleqqspdiaqg
    vhldrneedigagdqglmfgyatdeteecmpltivlahklnaklaelrrngtlpwlrpds
    ktqvtvqymqdrgavlpirvhtivisvqhdeevcldemrdalkekvikavvpakyldedt
    iyhlqpsgrfviggpqgdagltgrkiivdtyggwgahgggafsgkdytkvdrsaayaarw
    vakslvkgglcrrvlvqvsyaigvshplsisifhygtsqkserelleivkknfdlrpgvi
    vrdldlkkpiyqrtaayghfgrdsfpwevpkklky
    

    Sequence, based on observed residues (ATOM records): (download)
    >4ndnD (D:)
    eegtflftsesvgeghpdkicdqisdavldahlqqdpdakvacetvaktgmillageits
    raavdyqkvvreavkhigyddsskgfdyktcnvlvaleqqspdiaqgvhldrneedigag
    dqglmfgyatdeteecmpltivlahklnaklaelrrngtlpwlrpdsktqvtvqymqdrg
    avlpirvhtivisvqhdeevcldemrdalkekvikavvpakyldedtiyhlqpsgrfvig
    gpqgdagltgrkiivdtyggwgahgggafsgkdytkvdrsaayaarwvakslvkgglcrr
    vlvqvsyaigvshplsisifhygtsqkserelleivkknfdlrpgvivrdldlkkpiyqr
    taayghfgrdsfpwevpkklky
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >4ndnE (E:)
    mpempedmeqeevnipnrrvlvtgatgllgravhkefqqnnwhavgcgfrrarpkfeqvn
    lldsnavhhiihdfqphvivhcaaerrpdvvenqpdaasqlnvdasgnlakeaaavgafl
    iyissdyvfdgtnppyreedipaplnlygktkldgekavlennlgaavlripilygevek
    leesavtvmfdkvqfsnksanmdhwqqrfpthvkdvatvcrqlaekrmldpsikgtfhws
    gneqmtkyemacaiadafnlpsshlrpitdspvlgaqrprnaqldcskletlgigqrtpf
    rigikeslwpflidkrwrqtvfh
    

    Sequence, based on observed residues (ATOM records): (download)
    >4ndnE (E:)
    ipnrrvlvtgatgllgravhkefqqnnwhavgcgfrrarpkfeqvnlldsnavhhiihdf
    qphvivhcaaerrpdvvenqpdaasqlnvdasgnlakeaaavgafliyissdyvfdgtnp
    pyreedipaplnlygktkldgekavlennlgaavlripilygevekleesavtvmfdkvq
    fsnksanmdhwqqrfpthvkdvatvcrqlaekrmldpsikgtfhwsgneqmtkyemacai
    adafnlpsshlrpitdspvlgaqrprnaqldcskletlgigqrtpfrigikeslwpflid
    krwrqtvfh
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >4ndnF (F:)
    mpempedmeqeevnipnrrvlvtgatgllgravhkefqqnnwhavgcgfrrarpkfeqvn
    lldsnavhhiihdfqphvivhcaaerrpdvvenqpdaasqlnvdasgnlakeaaavgafl
    iyissdyvfdgtnppyreedipaplnlygktkldgekavlennlgaavlripilygevek
    leesavtvmfdkvqfsnksanmdhwqqrfpthvkdvatvcrqlaekrmldpsikgtfhws
    gneqmtkyemacaiadafnlpsshlrpitdspvlgaqrprnaqldcskletlgigqrtpf
    rigikeslwpflidkrwrqtvfh
    

    Sequence, based on observed residues (ATOM records): (download)
    >4ndnF (F:)
    ipnrrvlvtgatgllgravhkefqqnnwhavgcgfrrarpkfeqvnlldsnavhhiihdf
    qphvivhcaaerrpdvdaasqlnvdasgnlakeaaavgafliyissdyvfdgtnppyree
    dipaplnlygktkldgekavlennlgaavlripilygevekleesavtvmfdkvqfsnks
    anmdhwqqrfpthvkdvatvcrqlaekrmldpsikgtfhwsgneqmtkyemacaiadafn
    lpsshlrpitdspvlgaqrprnaqldcskletlgigqrtpfrigikeslwpflidkrwrq
    tvfh