PDB entry 4nd4

View 4nd4 on RCSB PDB site
Description: Crystal structure of the lactate dehydrogenase from cryptosporidium parvum complexed with substrate (pyruvic acid) and cofactor (b-nicotinamide adenine dinucleotide)
Class: oxidoreductase
Keywords: Rossmann fold, Dehydrogenase, NAD binding, OXIDOREDUCTASE
Deposited on 2013-10-25, released 2014-12-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-07-17, with a file datestamp of 2019-07-12.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase
    Species: Cryptosporidium parvum [TaxId:353152]
    Gene: cgd7_480, LDH1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5CYZ2 (0-End)
      • see remark 999 (183)
    Domains in SCOPe 2.08: d4nd4a1, d4nd4a2
  • Chain 'B':
    Compound: Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase
    Species: Cryptosporidium parvum [TaxId:353152]
    Gene: cgd7_480, LDH1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5CYZ2 (0-End)
      • see remark 999 (183)
    Domains in SCOPe 2.08: d4nd4b1, d4nd4b2
  • Heterogens: NAD, PYR, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4nd4A (A:)
mierrkiavigsgqiggniayivgkdnladvvlfdiaegipqgkaldithsmvmfgstsk
vigtndyadisgsdvviitasipgrpkddrsellfgnarildsvaegvkkycpnafvici
tnpldvmvshfqkvsglphnkvcgmagvldssrfrtfiaqhfgvnasdvsanvigghgdg
mvpatssvsvggvplssfikqglitqeqideivchtriawkevadnlktgtayfapaaaa
vkmaeaylkdkkavvpcsafcsnhygvkgiymgvptiigkngvedileldltpleqkllg
esinevntiskvldnapaaga

    Sequence, based on observed residues (ATOM records): (download) 
    >4nd4A (A:)
mierrkiavigsgqiggniayivgkdnladvvlfdiaegipqgkaldithsmvmfgstsk
vigtndyadisgsdvviitasipgrpkddrsellfgnarildsvaegvkkycpnafvici
tnpldvmvshfqkvsglphnkvcgmagvldssrfrtfiaqhfgvnasdvsanvigghgdg
mvpatssvsvggvplssfikqglitqeqideivchtriawkevadnlktgtayfapaaaa
vkmaeaylkdkkavvpcsafcsnhygvkgiymgvptiigkngvedileldltpleqkllg
esinevntiskvldnap

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4nd4B (B:)
mierrkiavigsgqiggniayivgkdnladvvlfdiaegipqgkaldithsmvmfgstsk
vigtndyadisgsdvviitasipgrpkddrsellfgnarildsvaegvkkycpnafvici
tnpldvmvshfqkvsglphnkvcgmagvldssrfrtfiaqhfgvnasdvsanvigghgdg
mvpatssvsvggvplssfikqglitqeqideivchtriawkevadnlktgtayfapaaaa
vkmaeaylkdkkavvpcsafcsnhygvkgiymgvptiigkngvedileldltpleqkllg
esinevntiskvldnapaaga

    Sequence, based on observed residues (ATOM records): (download) 
    >4nd4B (B:)
mierrkiavigsgqiggniayivgkdnladvvlfdiaegipqgkaldithsmvmfgstsk
vigtndyadisgsdvviitasipgrpkddrsellfgnarildsvaegvkkycpnafvici
tnpldvmvshfqkvsglphnkvcgmagvldssrfrtfiaqhfgvnasdvsanvigghgdg
mvpatssvsvggvplssfikqglitqeqideivchtriawkevadnlktgtayfapaaaa
vkmaeaylkdkkavvpcsafcsnhygvkgiymgvptiigkngvedileldltpleqkllg
esinevntiskvldnap