PDB entry 4ncs
View 4ncs on RCSB PDB site
Description: Human sialidase 2 in complex with 2,3-difluorosialic acid (covalent intermediate)
Class: hydrolase
Keywords: Sialidase, Human neuraminidase, fluoro-sialic acid, Hydrolase
Deposited on
2013-10-25, released
2013-12-25
The last revision prior to the SCOPe 2.05 freeze date was dated
2014-04-02, with a file datestamp of
2014-03-28.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.164
AEROSPACI score: 0.34
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Sialidase-2
Species: Homo sapiens [TaxId:9606]
Gene: NEU2
Database cross-references and differences (RAF-indexed):
- Uniprot Q9Y3R4
- engineered mutation (169)
Domains in SCOPe 2.05: d4ncsa_ - Heterogens: FSR, PO4, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4ncsA (A:)
gsmaslpvlqkesvfqsgahayripallylpgqqsllafaeqraskkaehaelivlrrgd
ydapthqvqwqaqevvaqarldghrsmnpcplydaqtgtlflffiaipgqvteqqqlqtr
anvtrlcqvtstdhgrtwssprdltdaaigpayrewstfavgpghclqlndrarslvvpa
yayrklhpiqrpipsafcflshdhgrtwarghfvaqdtlecqvaevetgeqrvvtlnars
hlrarvqaqstndgldfqesqlvkklvepppqgcqgsvisfpsprsgpgspaqwllythp
thswqradlgaylnprppapeawsepvllakgscaysdlqsmgtgpdgsplfgclyeand
yeeivflmftlkqafpaeylpq
Sequence, based on observed residues (ATOM records): (download)
>4ncsA (A:)
aslpvlqkesvfqsgahayripallylpgqqsllafaeqraaelivlrrgdydapthqvq
wqaqevvaqarldghrsmnpcplydaqtgtlflffiaipganvtrlcqvtstdhgrtwss
prdltdaaigpayrewstfavgpghclqlndrarslvvpayayrklhpiqrpipsafcfl
shdhgrtwarghfvaqdtlecqvaeveqrvvtlnarshlrarvqaqstndgldfqesqlv
kklvepppqgcqgsvisfpspraqwllythpthswqradlgaylnprppapeawsepvll
akgscaysdlqsmgtgpdgsplfgclyeandyeeivflmftlkqafpaey