PDB entry 4nc5

View 4nc5 on RCSB PDB site
Description: Human sialidase 2 in complex with 2,3-difluorosialic acid (covalent intermediate)
Class: hydrolase
Keywords: Human neuraminidase, sialidase, HYDROLASE
Deposited on 2013-10-24, released 2013-11-06
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-15, with a file datestamp of 2017-11-10.
Experiment type: XRAY
Resolution: 2.51 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Sialidase-2
    Species: Homo sapiens [TaxId:9606]
    Gene: NEU2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y3R4
      • engineered mutation (169)
    Domains in SCOPe 2.07: d4nc5a1, d4nc5a2
  • Heterogens: FSI, PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4nc5A (A:)
gsmaslpvlqkesvfqsgahayripallylpgqqsllafaeqraskkaehaelivlrrgd
ydapthqvqwqaqevvaqarldghrsmnpcplydaqtgtlflffiaipgqvteqqqlqtr
anvtrlcqvtstdhgrtwssprdltdaaigpayrewstfavgpghclqlndrarslvvpa
yayrklhpiqrpipsafcflshdhgrtwarghfvaqdtlecqvaevetgeqrvvtlnars
hlrarvqaqstndgldfqesqlvkklvepppqgcqgsvisfpsprsgpgspaqwllythp
thswqradlgaylnprppapeawsepvllakgscaysdlqsmgtgpdgsplfgclyeand
yeeivflmftlkqafpaeylpq

    Sequence, based on observed residues (ATOM records): (download) 
    >4nc5A (A:)
slpvlqkesvfqsgahayripallylpgqqsllafaeqraaelivlrrgdydapthqvqw
qaqevvaqarldghrsmnpcplydaqtgtlflffiaipgqvranvtrlcqvtstdhgrtw
ssprdltdaaigpayrewstfavgpghclqlndrarslvvpayayrklhpiqrpipsafc
flshdhgrtwarghfvaqdtlecqvaevetqrvvtlnarshlrarvqaqstndgldfqes
qlvkklvepppqgcqgsvisfpspraqwllythpthswqradlgaylnprppapeawsep
vllakgscaysdlqsmgtgpdgsplfgclyeandyeeivflmftlkqafpaeyl