PDB entry 4n9u
View 4n9u on RCSB PDB site
Description: The role of lysine 200 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates
Class: transferase
Keywords: alpha-helical prenyltransferase fold, Isoprene Biosynthesis, Lipid Synthesis, Steroid Biosynthesis, Dimethylallyl Pyrophosphate, Isopentenyl Pyrophosphate, TRANSFERASE
Deposited on
2013-10-21, released
2014-10-22
The last revision prior to the SCOPe 2.08 freeze date was dated
2014-10-22, with a file datestamp of
2014-10-17.
Experiment type: XRAY
Resolution: 2.11 Å
R-factor: 0.194
AEROSPACI score: 0.34
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: farnesyl pyrophosphate synthase
Species: Homo sapiens [TaxId:9606]
Gene: FDPS, FPS, KIAA1293
Database cross-references and differences (RAF-indexed):
- Uniprot P14324
- conflict (74)
- engineered mutation (221)
Domains in SCOPe 2.08: d4n9ua_ - Heterogens: MG, RIS, EDO, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4n9uA (A:)
mgsshhhhhhssgrenlyfqghmngdqnsdvyaqekqdfvqhfsqivrvltedemghpei
gdaiarlkevleyntiggkynrgltvvvafrelveprkqdadslqrawtvgwcvellqaf
flvaddimdssltrrgqicwyqkpgvgldaindanlleaciyrllklycreqpyylnlie
lflqssyqteigqtldlltapqgnvdlvrftekryksivkygtafysfylpiaaamymag
idgekehanakkillemgeffqiqddyldlfgdpsvtgkigtdiqdnkcswlvvqclqra
tpeqyqilkenygqkeaekvarvkalyeeldlpavflqyeedsyshimalieqyaaplpp
avflglarkiykrrk
Sequence, based on observed residues (ATOM records): (download)
>4n9uA (A:)
dvyaqekqdfvqhfsqivrvltehpeigdaiarlkevleyntiggkynrgltvvvafrel
veprkqdadslqrawtvgwcvellqafflvaddimdssltrrgqicwyqkpgvgldaind
anlleaciyrllklycreqpyylnlielflqssyqteigqtldlltapqgnvdlvrftek
ryksivkygtafysfylpiaaamymagidgekehanakkillemgeffqiqddyldlfgd
psvtgkigtdiqdnkcswlvvqclqratpeqyqilkenygqkeaekvarvkalyeeldlp
avflqyeedsyshimalieqyaaplppavflglarkiy