PDB entry 4n90

View 4n90 on RCSB PDB site
Description: Crystal structure of ternary complex of TRAIL, DR5, and Fab fragment from a DR5 agonist antibody
Deposited on 2013-10-18, released 2014-09-03
The last revision was dated 2014-09-03, with a file datestamp of 2014-08-29.
Experiment type: XRAY
Resolution: 3.3 Å
R-factor: 0.229
AEROSPACI score: 0.11 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tumor necrosis factor ligand superfamily member 10
    Species: Homo sapiens [TaxId:9606]
    Gene: TNFSF10, APO2L, TRAIL
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Tumor necrosis factor ligand superfamily member 10
    Species: Homo sapiens [TaxId:9606]
    Gene: TNFSF10, APO2L, TRAIL
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Tumor necrosis factor ligand superfamily member 10
    Species: Homo sapiens [TaxId:9606]
    Gene: TNFSF10, APO2L, TRAIL
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4N90 (0-End)
  • Chain 'E':
    Compound: Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4N90 (0-End)
  • Chain 'F':
    Compound: Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4N90 (0-End)
  • Chain 'G':
    Compound: Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4N90 (0-End)
  • Chain 'H':
    Compound: Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4N90 (0-End)
  • Chain 'I':
    Compound: Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4N90 (0-End)
  • Chain 'R':
    Compound: Tumor necrosis factor receptor superfamily member 10B
    Species: Homo sapiens [TaxId:9606]
    Gene: TNFRSF10B, DR5, KILLER, TRAILR2, TRICK2, ZTNFR9, UNQ160/PRO186
    Database cross-references and differences (RAF-indexed):
  • Chain 'S':
    Compound: Tumor necrosis factor receptor superfamily member 10B
    Species: Homo sapiens [TaxId:9606]
    Gene: TNFRSF10B, DR5, KILLER, TRAILR2, TRICK2, ZTNFR9, UNQ160/PRO186
    Database cross-references and differences (RAF-indexed):
  • Chain 'T':
    Compound: Tumor necrosis factor receptor superfamily member 10B
    Species: Homo sapiens [TaxId:9606]
    Gene: TNFRSF10B, DR5, KILLER, TRAILR2, TRICK2, ZTNFR9, UNQ160/PRO186
    Database cross-references and differences (RAF-indexed):
  • Heterogens: ZN

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >4n90A (A:)
vrergpqrvaahitgtrgrsntlsspnsknekalgrkinswessrsghsflsnlhlrnge
lvihekgfyyiysqtyfrfqeeikentkndkqmvqyiykytsypdpillmksarnscwsk
daeyglysiyqggifelkendrifvsvtnehlidmdheasffgaflvg

    Sequence, based on observed residues (ATOM records):
    >4n90A (A:)
pqrvaahitgtrgrsntekalgrkinswessrsghsflsnlhlrngelvihekgfyyiys
qtyfrfqeeikentkndkqmvqyiykytsypdpillmksarnscwskdaeyglysiyqgg
ifelkendrifvsvtnehlidmdheasffgaflvg

  • Chain 'B':
    Sequence, based on SEQRES records:
    >4n90B (B:)
vrergpqrvaahitgtrgrsntlsspnsknekalgrkinswessrsghsflsnlhlrnge
lvihekgfyyiysqtyfrfqeeikentkndkqmvqyiykytsypdpillmksarnscwsk
daeyglysiyqggifelkendrifvsvtnehlidmdheasffgaflvg

    Sequence, based on observed residues (ATOM records):
    >4n90B (B:)
pqrvaahitgtrgrsntlkalgrkinswessrsghsflsnlhlrngelvihekgfyyiys
qtyfrfqeeikentkndkqmvqyiykytsypdpillmksarnscwskdaeyglysiyqgg
ifelkendrifvsvtnehlidmdheasffgaflvg

  • Chain 'C':
    Sequence, based on SEQRES records:
    >4n90C (C:)
vrergpqrvaahitgtrgrsntlsspnsknekalgrkinswessrsghsflsnlhlrnge
lvihekgfyyiysqtyfrfqeeikentkndkqmvqyiykytsypdpillmksarnscwsk
daeyglysiyqggifelkendrifvsvtnehlidmdheasffgaflvg

    Sequence, based on observed residues (ATOM records):
    >4n90C (C:)
pqrvaahitgtrgrsntkalgrkinswessrsghsflsnlhlrngelvihekgfyyiysq
tyfrfqeeikentkndkqmvqyiykytsypdpillmksarnscwskdaeyglysiyqggi
felkendrifvsvtnehlidmdheasffgaflvg

  • Chain 'D':
    Sequence, based on SEQRES records:
    >4n90D (D:)
qvqlqesgpglvkpsqtlsltctvsggsissgdyfwswirqlpgkglewighihnsgtty
ynpslksrvtisvdtskkqfslrlssvtaadtavyycardrggdyyygmdvwgqgttvtv
ssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlq
ssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepks

    Sequence, based on observed residues (ATOM records):
    >4n90D (D:)
qvqlqesgpglvkpsqtlsltctvsggsissgdyfwswirqlpgkglewighihnsgtty
ynpslksrvtisvdtskkqfslrlssvtaadtavyycardrggdyyygmdvwgqgttvtv
ssastkgpsvfplapssggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgl
yslssvvtvpssslgtqtyicnvnhkpsntkvdkkvep

  • Chain 'E':
    Sequence, based on SEQRES records:
    >4n90E (E:)
eivltqspgtlslspgeratlscrasqgisrsylawyqqkpgqapslliygassratgip
drfsgsgsgtdftltisrlepedfavyycqqfgsspwtfgqgtkveikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records):
    >4n90E (E:)
eivltqspgtlslspgeratlscrasqgisrsylawyqqkpgqapslliygassratgip
drfsgsgsgtdftltisrlepedfavyycqqfgsspwtfgqgtkveikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrge

  • Chain 'F':
    Sequence, based on SEQRES records:
    >4n90F (F:)
qvqlqesgpglvkpsqtlsltctvsggsissgdyfwswirqlpgkglewighihnsgtty
ynpslksrvtisvdtskkqfslrlssvtaadtavyycardrggdyyygmdvwgqgttvtv
ssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlq
ssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepks

    Sequence, based on observed residues (ATOM records):
    >4n90F (F:)
qvqlqesgpglvkpsqtlsltctvsggsissgdyfwswirqlpgkglewighihnsgtty
ynpslksrvtisvdtskkqfslrlssvtaadtavyycardrggdyyygmdvwgqgttvtv
ssastkgpsvfplaptaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglysls
svvtvpssslgtqtyicnvnhkpsntkvdkkvep

  • Chain 'G':
    Sequence, based on SEQRES records:
    >4n90G (G:)
eivltqspgtlslspgeratlscrasqgisrsylawyqqkpgqapslliygassratgip
drfsgsgsgtdftltisrlepedfavyycqqfgsspwtfgqgtkveikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records):
    >4n90G (G:)
eivltqspgtlslspgeratlscrasqgisrsylawyqqkpgqapslliygassratgip
drfsgsgsgtdftltisrlepedfavyycqqfgsspwtfgqgtkveikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrge

  • Chain 'H':
    Sequence, based on SEQRES records:
    >4n90H (H:)
qvqlqesgpglvkpsqtlsltctvsggsissgdyfwswirqlpgkglewighihnsgtty
ynpslksrvtisvdtskkqfslrlssvtaadtavyycardrggdyyygmdvwgqgttvtv
ssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlq
ssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepks

    Sequence, based on observed residues (ATOM records):
    >4n90H (H:)
qvqlqesgpglvkpsqtlsltctvsggsissgdyfwswirqlpgkglewighihnsgtty
ynpslksrvtisvdtskkqfslrlssvtaadtavyycardrggdyyygmdvwgqgttvtv
ssastkgpsvfplapgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglysl
ssvvtvpssslgtqtyicnvnhkpsntkvdkkvep

  • Chain 'I':
    Sequence, based on SEQRES records:
    >4n90I (I:)
eivltqspgtlslspgeratlscrasqgisrsylawyqqkpgqapslliygassratgip
drfsgsgsgtdftltisrlepedfavyycqqfgsspwtfgqgtkveikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records):
    >4n90I (I:)
eivltqspgtlslspgeratlscrasqgisrsylawyqqkpgqapslliygassratgip
drfsgsgsgtdftltisrlepedfavyycqqfgsspwtfgqgtkveikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrge

  • Chain 'R':
    Sequence, based on SEQRES records:
    >4n90R (R:)
tqqdlapqqraapqqkrsspseglcppghhisedgrdcisckygqdysthwndllfclrc
trcdsgevelspctttrntvcqceegtfreedspemcrkcrtgcprgmvkvgdctpwsdi
ecvhke

    Sequence, based on observed residues (ATOM records):
    >4n90R (R:)
sspseglcppghhisedgrdcisckygqdysthwndllfclrctrcdsgevelspctttr
ntvcqceegtfreedspemcrkcrtgcprgmvkvgdctpwsdiecvhk

  • Chain 'S':
    Sequence, based on SEQRES records:
    >4n90S (S:)
tqqdlapqqraapqqkrsspseglcppghhisedgrdcisckygqdysthwndllfclrc
trcdsgevelspctttrntvcqceegtfreedspemcrkcrtgcprgmvkvgdctpwsdi
ecvhke

    Sequence, based on observed residues (ATOM records):
    >4n90S (S:)
sspseglcppghhisedgrdcisckygqdysthwndllfclrctrcdsgevelspctttr
ntvcqceegtfreedspemcrkcrtgcprgmvkvgdctpwsdiecv

  • Chain 'T':
    Sequence, based on SEQRES records:
    >4n90T (T:)
tqqdlapqqraapqqkrsspseglcppghhisedgrdcisckygqdysthwndllfclrc
trcdsgevelspctttrntvcqceegtfreedspemcrkcrtgcprgmvkvgdctpwsdi
ecvhke

    Sequence, based on observed residues (ATOM records):
    >4n90T (T:)
sspseglcppghhisedgrdcisckygqdysthwndllfclrctrcdsgevelspctttr
ntvcqceegtfreedspemcrkcrtgcprgmvkvgdctpwsdiecvh