PDB entry 4n0f

View 4n0f on RCSB PDB site
Description: Human FcRn complexed with human serum albumin
Class: immune system
Keywords: alpha/beta, receptor, IgG constant domain, membrane, IMMUNE SYSTEM
Deposited on 2013-10-01, released 2014-02-05
The last revision prior to the SCOPe 2.06 freeze date was dated 2014-04-09, with a file datestamp of 2014-04-04.
Experiment type: XRAY
Resolution: 3.02 Å
R-factor: 0.225
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: igg receptor fcrn large subunit p51
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4n0fa1, d4n0fa2
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4n0fb_
  • Chain 'D':
    Compound: serum albumin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4n0fd1, d4n0fd2, d4n0fd3
  • Chain 'E':
    Compound: igg receptor fcrn large subunit p51
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4n0fe1, d4n0fe2
  • Chain 'F':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4n0ff_
  • Chain 'G':
    Compound: serum albumin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4n0fg1, d4n0fg2, d4n0fg3
  • Chain 'H':
    Compound: igg receptor fcrn large subunit p51
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4n0fh1, d4n0fh2
  • Chain 'I':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4n0fi_
  • Chain 'J':
    Compound: serum albumin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4n0fj1, d4n0fj2, d4n0fj3
  • Chain 'K':
    Compound: igg receptor fcrn large subunit p51
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4n0fk1, d4n0fk2
  • Chain 'L':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4n0fl_
  • Chain 'M':
    Compound: serum albumin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4n0fm1, d4n0fm2, d4n0fm3

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4n0fA (A:)
    hlsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswywek
    ettdlrikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnfdlk
    qgtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkeppsmr
    lkarpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssltvk
    sgdehhyccivqhaglaqplrvelespakss
    

    Sequence, based on observed residues (ATOM records): (download)
    >4n0fA (A:)
    hlsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswywek
    ettdlrikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnfdlk
    qgtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkeppsmr
    lkarpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssltvk
    sgdehhyccivqhaglaqplrvel
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4n0fB (B:)
    iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
    sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >4n0fD (D:)
    dahksevahrfkdlgeenfkalvliafaqylqqcpfedhvklvnevtefaktcvadesae
    ncdkslhtlfgdklctvatlretygemadccakqepernecflqhkddnpnlprlvrpev
    dvmctafhdneetflkkylyeiarrhpyfyapellffakrykaafteccqaadkaacllp
    kldelrdegkassakqrlkcaslqkfgerafkawavarlsqrfpkaefaevsklvtdltk
    vhtecchgdllecaddradlakyicenqdsissklkeccekpllekshciaevendempa
    dlpslaadfveskdvcknyaeakdvflgmflyeyarrhpdysvvlllrlaktyettlekc
    caaadphecyakvfdefkplveepqnlikqncelfeqlgeykfqnallvrytkkvpqvst
    ptlvevsrnlgkvgskcckhpeakrmpcaedylsvvlnqlcvlhektpvsdrvtkcctes
    lvnrrpcfsalevdetyvpkefnaetftfhadictlsekerqikkqtalvelvkhkpkat
    keqlkavmddfaafvekcckaddketcfaeegkklvaasqaalgl
    

    Sequence, based on observed residues (ATOM records): (download)
    >4n0fD (D:)
    hksevahrfkdlgeenfkalvliafaqylqqcpfedhvklvnevtefaktcvadesaenc
    dkslhtlfgdklctvatlretygemadccakqepernecflqhkddnpnlprlvrpevdv
    mctafhdneetflkkylyeiarrhpyfyapellffakrykaafteccqaadkaacllpkl
    delrdegkassakqrlkcaslqkfgerafkawavarlsqrfpkaefaevsklvtdltkvh
    tecchgdllecaddradlakyicenqdsissklkeccekpllekshciaevendempadl
    pslaadfveskdvcknyaeakdvflgmflyeyarrhpdysvvlllrlaktyettlekcca
    aadphecyakvfdefkplveepqnlikqncelfeqlgeykfqnallvrytkkvpqvstpt
    lvevsrnlgkvgskcckhpeakrmpcaedylsvvlnqlcvlhektpvsdrvtkccteslv
    nrrpcfsalevdetyvpkefnaetftfhadictlsekerqikkqtalvelvkhkpkatke
    qlkavmddfaafvekcckaddketcfaeegkklvaasqaalgl
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >4n0fE (E:)
    hlsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswywek
    ettdlrikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnfdlk
    qgtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkeppsmr
    lkarpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssltvk
    sgdehhyccivqhaglaqplrvelespakss
    

    Sequence, based on observed residues (ATOM records): (download)
    >4n0fE (E:)
    hlsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswywek
    ettdlrikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnfdlk
    qgtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkeppsmr
    lkarpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssltvk
    sgdehhyccivqhaglaqplrvel
    

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4n0fF (F:)
    iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
    sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'G':
    Sequence, based on SEQRES records: (download)
    >4n0fG (G:)
    dahksevahrfkdlgeenfkalvliafaqylqqcpfedhvklvnevtefaktcvadesae
    ncdkslhtlfgdklctvatlretygemadccakqepernecflqhkddnpnlprlvrpev
    dvmctafhdneetflkkylyeiarrhpyfyapellffakrykaafteccqaadkaacllp
    kldelrdegkassakqrlkcaslqkfgerafkawavarlsqrfpkaefaevsklvtdltk
    vhtecchgdllecaddradlakyicenqdsissklkeccekpllekshciaevendempa
    dlpslaadfveskdvcknyaeakdvflgmflyeyarrhpdysvvlllrlaktyettlekc
    caaadphecyakvfdefkplveepqnlikqncelfeqlgeykfqnallvrytkkvpqvst
    ptlvevsrnlgkvgskcckhpeakrmpcaedylsvvlnqlcvlhektpvsdrvtkcctes
    lvnrrpcfsalevdetyvpkefnaetftfhadictlsekerqikkqtalvelvkhkpkat
    keqlkavmddfaafvekcckaddketcfaeegkklvaasqaalgl
    

    Sequence, based on observed residues (ATOM records): (download)
    >4n0fG (G:)
    hksevahrfkdlgeenfkalvliafaqylqqcpfedhvklvnevtefaktcvadesaenc
    dkslhtlfgdklctvatlretygemadccakqepernecflqhkddnpnlprlvrpevdv
    mctafhdneetflkkylyeiarrhpyfyapellffakrykaafteccqaadkaacllpkl
    delrdegkassakqrlkcaslqkfgerafkawavarlsqrfpkaefaevsklvtdltkvh
    tecchgdllecaddradlakyicenqdsissklkeccekpllekshciaevendempadl
    pslaadfveskdvcknyaeakdvflgmflyeyarrhpdysvvlllrlaktyettlekcca
    aadphecyakvfdefkplveepqnlikqncelfeqlgeykfqnallvrytkkvpqvstpt
    lvevsrnlgkvgskcckhpeakrmpcaedylsvvlnqlcvlhektpvsdrvtkccteslv
    nrrpcfsalevdetyvpkefnaetftfhadictlsekerqikkqtalvelvkhkpkatke
    qlkavmddfaafvekcckaddketcfaeegkklvaasqaalgl
    

  • Chain 'H':
    Sequence, based on SEQRES records: (download)
    >4n0fH (H:)
    hlsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswywek
    ettdlrikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnfdlk
    qgtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkeppsmr
    lkarpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssltvk
    sgdehhyccivqhaglaqplrvelespakss
    

    Sequence, based on observed residues (ATOM records): (download)
    >4n0fH (H:)
    hlsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswywek
    ettdlrikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnfdlk
    qgtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkeppsmr
    lkarpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssltvk
    sgdehhyccivqhaglaqplrvel
    

  • Chain 'I':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4n0fI (I:)
    iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
    sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'J':
    Sequence, based on SEQRES records: (download)
    >4n0fJ (J:)
    dahksevahrfkdlgeenfkalvliafaqylqqcpfedhvklvnevtefaktcvadesae
    ncdkslhtlfgdklctvatlretygemadccakqepernecflqhkddnpnlprlvrpev
    dvmctafhdneetflkkylyeiarrhpyfyapellffakrykaafteccqaadkaacllp
    kldelrdegkassakqrlkcaslqkfgerafkawavarlsqrfpkaefaevsklvtdltk
    vhtecchgdllecaddradlakyicenqdsissklkeccekpllekshciaevendempa
    dlpslaadfveskdvcknyaeakdvflgmflyeyarrhpdysvvlllrlaktyettlekc
    caaadphecyakvfdefkplveepqnlikqncelfeqlgeykfqnallvrytkkvpqvst
    ptlvevsrnlgkvgskcckhpeakrmpcaedylsvvlnqlcvlhektpvsdrvtkcctes
    lvnrrpcfsalevdetyvpkefnaetftfhadictlsekerqikkqtalvelvkhkpkat
    keqlkavmddfaafvekcckaddketcfaeegkklvaasqaalgl
    

    Sequence, based on observed residues (ATOM records): (download)
    >4n0fJ (J:)
    hksevahrfkdlgeenfkalvliafaqylqqcpfedhvklvnevtefaktcvadesaenc
    dkslhtlfgdklctvatlretygemadccakqepernecflqhkddnpnlprlvrpevdv
    mctafhdneetflkkylyeiarrhpyfyapellffakrykaafteccqaadkaacllpkl
    delrdegkassakqrlkcaslqkfgerafkawavarlsqrfpkaefaevsklvtdltkvh
    tecchgdllecaddradlakyicenqdsissklkeccekpllekshciaevendempadl
    pslaadfveskdvcknyaeakdvflgmflyeyarrhpdysvvlllrlaktyettlekcca
    aadphecyakvfdefkplveepqnlikqncelfeqlgeykfqnallvrytkkvpqvstpt
    lvevsrnlgkvgskcckhpeakrmpcaedylsvvlnqlcvlhektpvsdrvtkccteslv
    nrrpcfsalevdetyvpkefnaetftfhadictlsekerqikkqtalvelvkhkpkatke
    qlkavmddfaafvekcckaddketcfaeegkklvaasqaalgl
    

  • Chain 'K':
    Sequence, based on SEQRES records: (download)
    >4n0fK (K:)
    hlsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswywek
    ettdlrikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnfdlk
    qgtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkeppsmr
    lkarpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssltvk
    sgdehhyccivqhaglaqplrvelespakss
    

    Sequence, based on observed residues (ATOM records): (download)
    >4n0fK (K:)
    hlsllyhltavsspapgtpafwvsgwlgpqqylsynslrgeaepcgawvwenqvswywek
    ettdlrikeklfleafkalggkgpytlqgllgcelgpdntsvptakfalngeefmnfdlk
    qgtwggdwpealaisqrwqqqdkaankeltfllfscphrlrehlergrgnlewkeppsmr
    lkarpsspgfsvltcsafsfyppelqlrflrnglaagtgqgdfgpnsdgsfhasssltvk
    sgdehhyccivqhaglaqplrvel
    

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4n0fL (L:)
    iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
    sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'M':
    Sequence, based on SEQRES records: (download)
    >4n0fM (M:)
    dahksevahrfkdlgeenfkalvliafaqylqqcpfedhvklvnevtefaktcvadesae
    ncdkslhtlfgdklctvatlretygemadccakqepernecflqhkddnpnlprlvrpev
    dvmctafhdneetflkkylyeiarrhpyfyapellffakrykaafteccqaadkaacllp
    kldelrdegkassakqrlkcaslqkfgerafkawavarlsqrfpkaefaevsklvtdltk
    vhtecchgdllecaddradlakyicenqdsissklkeccekpllekshciaevendempa
    dlpslaadfveskdvcknyaeakdvflgmflyeyarrhpdysvvlllrlaktyettlekc
    caaadphecyakvfdefkplveepqnlikqncelfeqlgeykfqnallvrytkkvpqvst
    ptlvevsrnlgkvgskcckhpeakrmpcaedylsvvlnqlcvlhektpvsdrvtkcctes
    lvnrrpcfsalevdetyvpkefnaetftfhadictlsekerqikkqtalvelvkhkpkat
    keqlkavmddfaafvekcckaddketcfaeegkklvaasqaalgl
    

    Sequence, based on observed residues (ATOM records): (download)
    >4n0fM (M:)
    hksevahrfkdlgeenfkalvliafaqylqqcpfedhvklvnevtefaktcvadesaenc
    dkslhtlfgdklctvatlretygemadccakqepernecflqhkddnpnlprlvrpevdv
    mctafhdneetflkkylyeiarrhpyfyapellffakrykaafteccqaadkaacllpkl
    delrdegkassakqrlkcaslqkfgerafkawavarlsqrfpkaefaevsklvtdltkvh
    tecchgdllecaddradlakyicenqdsissklkeccekpllekshciaevendempadl
    pslaadfveskdvcknyaeakdvflgmflyeyarrhpdysvvlllrlaktyettlekcca
    aadphecyakvfdefkplveepqnlikqncelfeqlgeykfqnallvrytkkvpqvstpt
    lvevsrnlgkvgskcckhpeakrmpcaedylsvvlnqlcvlhektpvsdrvtkccteslv
    nrrpcfsalevdetyvpkefnaetftfhadictlsekerqikkqtalvelvkhkpkatke
    qlkavmddfaafvekcckaddketcfaeegkklvaasqaalgl