PDB entry 4mzs

View 4mzs on RCSB PDB site
Description: Mouse cathepsin s with covalent ligand (3S,4S)-1-[(2-CHLOROPHENYL)SULFONYL]-N-[(2E)-2-IMINOETHYL]-4-(MORPHOLIN-4-YLCARBONYL)PYRROLIDINE-3-CARBOXAMIDE
Class: hydrolase/hydrolase inhibitor
Keywords: HYDROLASE, CYSTEINE PROTEASE, hydrolase-hydrolase inhibitor complex
Deposited on 2013-09-30, released 2014-08-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-15, with a file datestamp of 2017-11-10.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cathepsin S
    Species: Mus musculus [TaxId:10090]
    Gene: Ctss, Cats
    Database cross-references and differences (RAF-indexed):
    • Uniprot O70370 (Start-224)
      • variant (102)
    Domains in SCOPe 2.08: d4mzsa_
  • Chain 'B':
    Compound: cathepsin S
    Species: Mus musculus [TaxId:10090]
    Gene: Ctss, Cats
    Database cross-references and differences (RAF-indexed):
    • Uniprot O70370 (Start-224)
      • variant (102)
    Domains in SCOPe 2.08: d4mzsb_
  • Heterogens: 2EV, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4mzsA (A:)
    rsysnrtlpdtvdwrekgcvtevkyqgscgacwafsavgalegqlklktgklislsaqnl
    vdcsneekygnkgcgggymteafqyiidnggieadasypykamdekchynsknraatcsr
    yiqlpfgdedalkeavatkgpvsvgidashssfffyksgvyddpsctgnvnhgvlvvgyg
    tldgkdywlvknswglnfgdqgyirmarnnknhcgiasycsypei
    

    Sequence, based on observed residues (ATOM records): (download)
    >4mzsA (A:)
    lpdtvdwrekgcvtevkyqgscgacwafsavgalegqlklktgklislsaqnlvdcsnee
    kygnkgcgggymteafqyiidnggieadasypykamdekchynsknraatcsryiqlpfg
    dedalkeavatkgpvsvgidashssfffyksgvyddpsctgnvnhgvlvvgygtldgkdy
    wlvknswglnfgdqgyirmarnnknhcgiasycsypei
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4mzsB (B:)
    rsysnrtlpdtvdwrekgcvtevkyqgscgacwafsavgalegqlklktgklislsaqnl
    vdcsneekygnkgcgggymteafqyiidnggieadasypykamdekchynsknraatcsr
    yiqlpfgdedalkeavatkgpvsvgidashssfffyksgvyddpsctgnvnhgvlvvgyg
    tldgkdywlvknswglnfgdqgyirmarnnknhcgiasycsypei
    

    Sequence, based on observed residues (ATOM records): (download)
    >4mzsB (B:)
    lpdtvdwrekgcvtevkyqgscgacwafsavgalegqlklktgklislsaqnlvdcsnee
    kygnkgcgggymteafqyiidnggieadasypykamdekchynsknraatcsryiqlpfg
    dedalkeavatkgpvsvgidashssfffyksgvyddpsctgnvnhgvlvvgygtldgkdy
    wlvknswglnfgdqgyirmarnnknhcgiasycsypei