PDB entry 4mzo

View 4mzo on RCSB PDB site
Description: Mouse cathepsin s with covalent ligand (3S,4S)-N-[(2E)-2-IMINOETHYL]-4-(MORPHOLIN-4-YLCARBONYL)-1-(PHENYLSULFONYL)PYRROLIDINE-3-CARBOXAMIDE
Class: hydrolase/hydrolase inhibitor
Keywords: HYDROLASE, CYSTEINE PROTEASE, hydrolase-hydrolase inhibitor complex
Deposited on 2013-09-30, released 2014-09-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-15, with a file datestamp of 2017-11-10.
Experiment type: XRAY
Resolution: 1.47 Å
R-factor: N/A
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cathepsin S
    Species: Mus musculus [TaxId:10090]
    Gene: Ctss, Cats
    Database cross-references and differences (RAF-indexed):
    • Uniprot O70370 (Start-224)
      • variant (102)
    Domains in SCOPe 2.08: d4mzoa_
  • Chain 'B':
    Compound: cathepsin S
    Species: Mus musculus [TaxId:10090]
    Gene: Ctss, Cats
    Database cross-references and differences (RAF-indexed):
    • Uniprot O70370 (Start-224)
      • variant (102)
    Domains in SCOPe 2.08: d4mzob_
  • Chain 'C':
    Compound: cathepsin S
    Species: Mus musculus [TaxId:10090]
    Gene: Ctss, Cats
    Database cross-references and differences (RAF-indexed):
    • Uniprot O70370 (Start-224)
      • variant (102)
    Domains in SCOPe 2.08: d4mzoc_
  • Chain 'D':
    Compound: cathepsin S
    Species: Mus musculus [TaxId:10090]
    Gene: Ctss, Cats
    Database cross-references and differences (RAF-indexed):
    • Uniprot O70370 (Start-224)
      • variant (102)
    Domains in SCOPe 2.08: d4mzod_
  • Chain 'E':
    Compound: cathepsin S
    Species: Mus musculus [TaxId:10090]
    Gene: Ctss, Cats
    Database cross-references and differences (RAF-indexed):
    • Uniprot O70370 (Start-224)
      • variant (102)
    Domains in SCOPe 2.08: d4mzoe_
  • Chain 'F':
    Compound: cathepsin S
    Species: Mus musculus [TaxId:10090]
    Gene: Ctss, Cats
    Database cross-references and differences (RAF-indexed):
    • Uniprot O70370 (Start-224)
      • variant (102)
    Domains in SCOPe 2.08: d4mzof_
  • Chain 'G':
    Compound: cathepsin S
    Species: Mus musculus [TaxId:10090]
    Gene: Ctss, Cats
    Database cross-references and differences (RAF-indexed):
    • Uniprot O70370 (Start-224)
      • variant (102)
    Domains in SCOPe 2.08: d4mzog_
  • Chain 'H':
    Compound: cathepsin S
    Species: Mus musculus [TaxId:10090]
    Gene: Ctss, Cats
    Database cross-references and differences (RAF-indexed):
    • Uniprot O70370 (Start-224)
      • variant (102)
    Domains in SCOPe 2.08: d4mzoh_
  • Heterogens: 2EW, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4mzoA (A:)
rsysnrtlpdtvdwrekgcvtevkyqgscgacwafsavgalegqlklktgklislsaqnl
vdcsneekygnkgcgggymteafqyiidnggieadasypykamdekchynsknraatcsr
yiqlpfgdedalkeavatkgpvsvgidashssfffyksgvyddpsctgnvnhgvlvvgyg
tldgkdywlvknswglnfgdqgyirmarnnknhcgiasycsypei

    Sequence, based on observed residues (ATOM records): (download) 
    >4mzoA (A:)
lpdtvdwrekgcvtevkyqgscgacwafsavgalegqlklktgklislsaqnlvdcsnee
kygnkgcgggymteafqyiidnggieadasypykamdekchynsknraatcsryiqlpfg
dedalkeavatkgpvsvgidashssfffyksgvyddpsctgnvnhgvlvvgygtldgkdy
wlvknswglnfgdqgyirmarnnknhcgiasycsypei

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4mzoB (B:)
rsysnrtlpdtvdwrekgcvtevkyqgscgacwafsavgalegqlklktgklislsaqnl
vdcsneekygnkgcgggymteafqyiidnggieadasypykamdekchynsknraatcsr
yiqlpfgdedalkeavatkgpvsvgidashssfffyksgvyddpsctgnvnhgvlvvgyg
tldgkdywlvknswglnfgdqgyirmarnnknhcgiasycsypei

    Sequence, based on observed residues (ATOM records): (download) 
    >4mzoB (B:)
tlpdtvdwrekgcvtevkyqgscgacwafsavgalegqlklktgklislsaqnlvdcsne
ekygnkgcgggymteafqyiidnggieadasypykamdekchynsknraatcsryiqlpf
gdedalkeavatkgpvsvgidashssfffyksgvyddpsctgnvnhgvlvvgygtldgkd
ywlvknswglnfgdqgyirmarnnknhcgiasycsypei

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4mzoC (C:)
rsysnrtlpdtvdwrekgcvtevkyqgscgacwafsavgalegqlklktgklislsaqnl
vdcsneekygnkgcgggymteafqyiidnggieadasypykamdekchynsknraatcsr
yiqlpfgdedalkeavatkgpvsvgidashssfffyksgvyddpsctgnvnhgvlvvgyg
tldgkdywlvknswglnfgdqgyirmarnnknhcgiasycsypei

    Sequence, based on observed residues (ATOM records): (download) 
    >4mzoC (C:)
lpdtvdwrekgcvtevkyqgscgacwafsavgalegqlklktgklislsaqnlvdcsnee
kygnkgcgggymteafqyiidnggieadasypykamdekchynsknraatcsryiqlpfg
dedalkeavatkgpvsvgidashssfffyksgvyddpsctgnvnhgvlvvgygtldgkdy
wlvknswglnfgdqgyirmarnnknhcgiasycsypei

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4mzoD (D:)
rsysnrtlpdtvdwrekgcvtevkyqgscgacwafsavgalegqlklktgklislsaqnl
vdcsneekygnkgcgggymteafqyiidnggieadasypykamdekchynsknraatcsr
yiqlpfgdedalkeavatkgpvsvgidashssfffyksgvyddpsctgnvnhgvlvvgyg
tldgkdywlvknswglnfgdqgyirmarnnknhcgiasycsypei

    Sequence, based on observed residues (ATOM records): (download) 
    >4mzoD (D:)
lpdtvdwrekgcvtevkyqgscgacwafsavgalegqlklktgklislsaqnlvdcsnee
kygnkgcgggymteafqyiidnggieadasypykamdekchynsknraatcsryiqlpfg
dedalkeavatkgpvsvgidashssfffyksgvyddpsctgnvnhgvlvvgygtldgkdy
wlvknswglnfgdqgyirmarnnknhcgiasycsypei

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4mzoE (E:)
rsysnrtlpdtvdwrekgcvtevkyqgscgacwafsavgalegqlklktgklislsaqnl
vdcsneekygnkgcgggymteafqyiidnggieadasypykamdekchynsknraatcsr
yiqlpfgdedalkeavatkgpvsvgidashssfffyksgvyddpsctgnvnhgvlvvgyg
tldgkdywlvknswglnfgdqgyirmarnnknhcgiasycsypei

    Sequence, based on observed residues (ATOM records): (download) 
    >4mzoE (E:)
lpdtvdwrekgcvtevkyqgscgacwafsavgalegqlklktgklislsaqnlvdcsnee
kygnkgcgggymteafqyiidnggieadasypykamdekchynsknraatcsryiqlpfg
dedalkeavatkgpvsvgidashssfffyksgvyddpsctgnvnhgvlvvgygtldgkdy
wlvknswglnfgdqgyirmarnnknhcgiasycsypei

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >4mzoF (F:)
rsysnrtlpdtvdwrekgcvtevkyqgscgacwafsavgalegqlklktgklislsaqnl
vdcsneekygnkgcgggymteafqyiidnggieadasypykamdekchynsknraatcsr
yiqlpfgdedalkeavatkgpvsvgidashssfffyksgvyddpsctgnvnhgvlvvgyg
tldgkdywlvknswglnfgdqgyirmarnnknhcgiasycsypei

    Sequence, based on observed residues (ATOM records): (download) 
    >4mzoF (F:)
tlpdtvdwrekgcvtevkyqgscgacwafsavgalegqlklktgklislsaqnlvdcsne
ekygnkgcgggymteafqyiidnggieadasypykamdekchynsknraatcsryiqlpf
gdedalkeavatkgpvsvgidashssfffyksgvyddpsctgnvnhgvlvvgygtldgkd
ywlvknswglnfgdqgyirmarnnknhcgiasycsypei

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >4mzoG (G:)
rsysnrtlpdtvdwrekgcvtevkyqgscgacwafsavgalegqlklktgklislsaqnl
vdcsneekygnkgcgggymteafqyiidnggieadasypykamdekchynsknraatcsr
yiqlpfgdedalkeavatkgpvsvgidashssfffyksgvyddpsctgnvnhgvlvvgyg
tldgkdywlvknswglnfgdqgyirmarnnknhcgiasycsypei

    Sequence, based on observed residues (ATOM records): (download) 
    >4mzoG (G:)
lpdtvdwrekgcvtevkyqgscgacwafsavgalegqlklktgklislsaqnlvdcsnee
kygnkgcgggymteafqyiidnggieadasypykamdekchynsknraatcsryiqlpfg
dedalkeavatkgpvsvgidashssfffyksgvyddpsctgnvnhgvlvvgygtldgkdy
wlvknswglnfgdqgyirmarnnknhcgiasycsypei

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >4mzoH (H:)
rsysnrtlpdtvdwrekgcvtevkyqgscgacwafsavgalegqlklktgklislsaqnl
vdcsneekygnkgcgggymteafqyiidnggieadasypykamdekchynsknraatcsr
yiqlpfgdedalkeavatkgpvsvgidashssfffyksgvyddpsctgnvnhgvlvvgyg
tldgkdywlvknswglnfgdqgyirmarnnknhcgiasycsypei

    Sequence, based on observed residues (ATOM records): (download) 
    >4mzoH (H:)
lpdtvdwrekgcvtevkyqgscgacwafsavgalegqlklktgklislsaqnlvdcsnee
kygnkgcgggymteafqyiidnggieadasypykamdekchynsknraatcsryiqlpfg
dedalkeavatkgpvsvgidashssfffyksgvyddpsctgnvnhgvlvvgygtldgkdy
wlvknswglnfgdqgyirmarnnknhcgiasycsypei