PDB entry 4mzi

View 4mzi on RCSB PDB site
Description: Crystal structure of a human mutant p53
Class: antitumor protein
Keywords: loop L1, tumor suppressor, antitumour protein, dna binding, ANTITUMOR PROTEIN
Deposited on 2013-09-30, released 2014-01-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-04-09, with a file datestamp of 2014-04-04.
Experiment type: XRAY
Resolution: 1.25 Å
R-factor: 0.198
AEROSPACI score: 0.67 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cellular tumor antigen p53
    Species: Homo sapiens [TaxId:9606]
    Gene: TP53, P53
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04637
      • engineered mutation (28-29)
      • conflict (42)
      • conflict (48)
      • conflict (53)
      • natural variant (89)
      • natural variant (110)
      • conflict (116)
      • natural variant (136)
      • natural variant (140-141)
      • conflict (142)
      • natural variant (143)
      • conflict (160)
      • conflict (175)
    Domains in SCOPe 2.08: d4mzia_
  • Heterogens: ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4mziA (A:)
msssvpsqktyqgsygfrlgflhsgtakfgtctyspalnkmfvqlaktvpvqlyvdstpp
pgtrvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntf
rhsvvvpyeppevgsdyttiyfkfmcnsscmggmnrrpilviitledssgnllgrdsfev
rvcacpgrdrrteeenlrkk

    Sequence, based on observed residues (ATOM records): (download) 
    >4mziA (A:)
svpsqktyqgsygfrlgflhsgtakfgtctyspalnkmfvqlaktvpvqlyvdstpppgt
rvramaiykqsqhmtevvrrcphherssdsdglappqhlirvegnlraeylddpntfrhs
vvvpyeppevgsdyttiyfkfmcnsscmggmnrrpilviitledssgnllgrdsfevrvc
acpgrdrrteeen