PDB entry 4mz4

View 4mz4 on RCSB PDB site
Description: Discovery of an Irreversible HCV NS5B Polymerase Inhibitor
Class: transferase/transferase inhibitor
Keywords: RNA-dependent RNA polymerase, transferase-transferase inhibitor complex
Deposited on 2013-09-29, released 2013-12-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-12-18, with a file datestamp of 2013-12-13.
Experiment type: XRAY
Resolution: 1.63 Å
R-factor: 0.176
AEROSPACI score: 0.5 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: RNA-directed RNA polymerase
    Species: Hepatitis C virus [TaxId:420174]
    Gene: NS5B
    Database cross-references and differences (RAF-indexed):
    • Uniprot O92972 (0-End)
      • conflict (439)
      • conflict (519)
    Domains in SCOPe 2.08: d4mz4a_
  • Chain 'B':
    Compound: RNA-directed RNA polymerase
    Species: Hepatitis C virus [TaxId:420174]
    Gene: NS5B
    Database cross-references and differences (RAF-indexed):
    • Uniprot O92972 (0-End)
      • conflict (439)
      • conflict (519)
    Domains in SCOPe 2.08: d4mz4b_
  • Heterogens: 2F3, PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4mz4A (A:)
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiy
qccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkat
aacraaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlw
armilmthffsillaqeqlgkaldcqiygacysiepldlpqiierlhglsaftlhsyspg
einrvasclrklgvpplrtwrhrarsvrakllsqggraaicgrylfnwavrtklkltpip
aasqldlsgwfvagysggdiyhslsrarprenlyfq

    Sequence, based on observed residues (ATOM records): (download) 
    >4mz4A (A:)
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqrkparlivfpdlgvrvcekmalydvvstlpqa
vmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiyqccdl
apearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkataacra
aklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydlelits
cssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlwarmil
mthffsillaqeqlgkaldcqiygacysiepldlpqiierlhglsaftlhsyspgeinrv
asclrklgvpplrtwrhrarsvrakllsqggraaicgrylfnwavrtklkltpipaasql
dlsgwfvagysggdiyhslsrar

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4mz4B (B:)
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiy
qccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkat
aacraaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlw
armilmthffsillaqeqlgkaldcqiygacysiepldlpqiierlhglsaftlhsyspg
einrvasclrklgvpplrtwrhrarsvrakllsqggraaicgrylfnwavrtklkltpip
aasqldlsgwfvagysggdiyhslsrarprenlyfq

    Sequence, based on observed residues (ATOM records): (download) 
    >4mz4B (B:)
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqrkparlivfpdlgvrvcekmalydvvstlpqa
vmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiyqccdl
apearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkataacra
aklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydlelits
cssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlwarmil
mthffsillaqeqlgkaldcqiygacysiepldlpqiierlhglsaftlhsyspgeinrv
asclrklgvpplrtwrhrarsvrakllsqggraaicgrylfnwavrtklkltpipaasql
dlsgwfvagysggdiyhsls