PDB entry 4myx

View 4myx on RCSB PDB site
Description: Crystal Structure of the Inosine 5'-monophosphate Dehydrogenase, with a Internal Deletion of CBS Domain from Bacillus anthracis str. Ame complexed with P32
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: Structural Genomics, NIAID, National Institute of Allergy and Infectious Diseases, Center for Structural Genomics of Infectious Diseases, CSGID, TIM barrel, alpha-beta structure, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Deposited on 2013-09-28, released 2014-07-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-01-24, with a file datestamp of 2018-01-19.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: inosine-5'-monophosphate dehydrogenase
    Species: Bacillus anthracis [TaxId:198094]
    Gene: guaB, BA_0008, BAS0011, GBAA_0008
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q81W29 (24-114)
      • expression tag (21-23)
      • linker (115)
    • Uniprot Q81W29 (117-383)
      • linker (116)
    Domains in SCOPe 2.08: d4myxa1, d4myxa2
  • Chain 'B':
    Compound: inosine-5'-monophosphate dehydrogenase
    Species: Bacillus anthracis [TaxId:198094]
    Gene: guaB, BA_0008, BAS0011, GBAA_0008
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q81W29 (24-114)
      • expression tag (19-23)
      • linker (115)
    • Uniprot Q81W29 (117-End)
      • linker (116)
    Domains in SCOPe 2.08: d4myxb1, d4myxb2
  • Chain 'C':
    Compound: inosine-5'-monophosphate dehydrogenase
    Species: Bacillus anthracis [TaxId:198094]
    Gene: guaB, BA_0008, BAS0011, GBAA_0008
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q81W29 (24-114)
      • expression tag (22-23)
      • linker (115)
    • Uniprot Q81W29 (117-End)
      • linker (116)
    Domains in SCOPe 2.08: d4myxc1, d4myxc2
  • Chain 'D':
    Compound: inosine-5'-monophosphate dehydrogenase
    Species: Bacillus anthracis [TaxId:198094]
    Gene: guaB, BA_0008, BAS0011, GBAA_0008
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q81W29 (24-114)
      • expression tag (21-23)
      • linker (115)
    • Uniprot Q81W29 (117-End)
      • linker (116)
    Domains in SCOPe 2.08: d4myxd1, d4myxd2
  • Chain 'E':
    Compound: inosine-5'-monophosphate dehydrogenase
    Species: Bacillus anthracis [TaxId:198094]
    Gene: guaB, BA_0008, BAS0011, GBAA_0008
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q81W29 (24-114)
      • expression tag (20-23)
      • linker (115)
    • Uniprot Q81W29 (117-End)
      • linker (116)
    Domains in SCOPe 2.08: d4myxe1, d4myxe2
  • Chain 'F':
    Compound: inosine-5'-monophosphate dehydrogenase
    Species: Bacillus anthracis [TaxId:198094]
    Gene: guaB, BA_0008, BAS0011, GBAA_0008
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q81W29 (24-114)
      • expression tag (21-23)
      • linker (115)
    • Uniprot Q81W29 (117-End)
      • linker (116)
    Domains in SCOPe 2.08: d4myxf1, d4myxf2
  • Chain 'G':
    Compound: inosine-5'-monophosphate dehydrogenase
    Species: Bacillus anthracis [TaxId:198094]
    Gene: guaB, BA_0008, BAS0011, GBAA_0008
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q81W29 (24-114)
      • expression tag (19-23)
      • linker (115)
    • Uniprot Q81W29 (117-End)
      • linker (116)
    Domains in SCOPe 2.08: d4myxg1, d4myxg2
  • Chain 'H':
    Compound: inosine-5'-monophosphate dehydrogenase
    Species: Bacillus anthracis [TaxId:198094]
    Gene: guaB, BA_0008, BAS0011, GBAA_0008
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q81W29 (24-114)
      • expression tag (21-23)
      • linker (115)
    • Uniprot Q81W29 (117-End)
      • linker (116)
    Domains in SCOPe 2.08: d4myxh1, d4myxh2
  • Heterogens: IMP, 2F0, FMT, GOL, MLI, EDO, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4myxA (A:)
mhhhhhhssgvdlgtenlyfqsnamweskfvkegltfddvllvpaksdvlprevsvktvl
seslqlniplisagmdtvteadmaiamarqgglgiihknmsieqqaeqvdkvkrsggllv
gaavgvtadamtridalvkasvdaivldtahghsqgvidkvkevrakypslniiagnvat
aeatkalieaganvvkvgigpgsicttrvvagvgvpqltavydcatearkhgipviadgg
ikysgdmvkalaagahvvmlgsmfagvaespgeteiyqgrqfkvyrgmgsvgamekgskd
ryfqegnkklvpegiegrvpykgpladtvhqlvgglragmgycgaqdleflrenaqfirm
sgaglleshphhvqitkeapnysl

    Sequence, based on observed residues (ATOM records): (download) 
    >4myxA (A:)
snamweskfvkegltfddvllvpaksdvlprevsvktvlseslqlniplisagmdtvtea
dmaiamarqgglgiihknmsieqqaeqvdkvkrsggllvgaavgvtadamtridalvkas
vdaivldtahghsqgvidkvkevrakypslniiagnvataeatkalieaganvvkvgigp
gsicttrvvagvgvpqltavydcatearkhgipviadggikysgdmvkalaagahvvmlg
smfagvaespgeteiyqgrqfkvyrgmgsvgamekklvpegiegrvpykgpladtvhqlv
gglragmgycgaqdleflrenaqfirmsgaglleshphhvqitkeapnysl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4myxB (B:)
mhhhhhhssgvdlgtenlyfqsnamweskfvkegltfddvllvpaksdvlprevsvktvl
seslqlniplisagmdtvteadmaiamarqgglgiihknmsieqqaeqvdkvkrsggllv
gaavgvtadamtridalvkasvdaivldtahghsqgvidkvkevrakypslniiagnvat
aeatkalieaganvvkvgigpgsicttrvvagvgvpqltavydcatearkhgipviadgg
ikysgdmvkalaagahvvmlgsmfagvaespgeteiyqgrqfkvyrgmgsvgamekgskd
ryfqegnkklvpegiegrvpykgpladtvhqlvgglragmgycgaqdleflrenaqfirm
sgaglleshphhvqitkeapnysl

    Sequence, based on observed residues (ATOM records): (download) 
    >4myxB (B:)
fqsnamweskfvkegltfddvllvpaksdvlprevsvktvlseslqlniplisagmdtvt
eadmaiamarqgglgiihknmsieqqaeqvdkvkrsggllvgaavgvtadamtridalvk
asvdaivldtahghsqgvidkvkevrakypslniiagnvataeatkalieaganvvkvgi
gpgsicttrvvagvgvpqltavydcatearkhgipviadggikysgdmvkalaagahvvm
lgsmfagvaespgeteiyqgrqfkvyrgmgsvgamekgskklvpegiegrvpykgpladt
vhqlvgglragmgycgaqdleflrenaqfirmsgaglleshphhvqitkeapnys

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4myxC (C:)
mhhhhhhssgvdlgtenlyfqsnamweskfvkegltfddvllvpaksdvlprevsvktvl
seslqlniplisagmdtvteadmaiamarqgglgiihknmsieqqaeqvdkvkrsggllv
gaavgvtadamtridalvkasvdaivldtahghsqgvidkvkevrakypslniiagnvat
aeatkalieaganvvkvgigpgsicttrvvagvgvpqltavydcatearkhgipviadgg
ikysgdmvkalaagahvvmlgsmfagvaespgeteiyqgrqfkvyrgmgsvgamekgskd
ryfqegnkklvpegiegrvpykgpladtvhqlvgglragmgycgaqdleflrenaqfirm
sgaglleshphhvqitkeapnysl

    Sequence, based on observed residues (ATOM records): (download) 
    >4myxC (C:)
namweskfvkegltfddvllvpaksdvlprevsvktvlseslqlniplisagmdtvtead
maiamarqgglgiihknmsieqqaeqvdkvkrsggllvgaavgvtadamtridalvkasv
daivldtahghsqgvidkvkevrakypslniiagnvataeatkalieaganvvkvgigpg
sicttrvvagvgvpqltavydcatearkhgipviadggikysgdmvkalaagahvvmlgs
mfagvaespgeteiyqgrqfkvyrgmgsvgameklvpegiegrvpykgpladtvhqlvgg
lragmgycgaqdleflrenaqfirmsgaglleshphhvqitkeapnys

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4myxD (D:)
mhhhhhhssgvdlgtenlyfqsnamweskfvkegltfddvllvpaksdvlprevsvktvl
seslqlniplisagmdtvteadmaiamarqgglgiihknmsieqqaeqvdkvkrsggllv
gaavgvtadamtridalvkasvdaivldtahghsqgvidkvkevrakypslniiagnvat
aeatkalieaganvvkvgigpgsicttrvvagvgvpqltavydcatearkhgipviadgg
ikysgdmvkalaagahvvmlgsmfagvaespgeteiyqgrqfkvyrgmgsvgamekgskd
ryfqegnkklvpegiegrvpykgpladtvhqlvgglragmgycgaqdleflrenaqfirm
sgaglleshphhvqitkeapnysl

    Sequence, based on observed residues (ATOM records): (download) 
    >4myxD (D:)
snamweskfvkegltfddvllvpaksdvlprevsvktvlseslqlniplisagmdtvtea
dmaiamarqgglgiihknmsieqqaeqvdkvkrsggllvgaavgvtadamtridalvkas
vdaivldtahghsqgvidkvkevrakypslniiagnvataeatkalieaganvvkvgigp
gsicttrvvagvgvpqltavydcatearkhgipviadggikysgdmvkalaagahvvmlg
smfagvaespgeteiyqgrqfkvyrgmgsvgamekgkklvpegiegrvpykgpladtvhq
lvgglragmgycgaqdleflrenaqfirmsgaglleshphhvqitkeapnys

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4myxE (E:)
mhhhhhhssgvdlgtenlyfqsnamweskfvkegltfddvllvpaksdvlprevsvktvl
seslqlniplisagmdtvteadmaiamarqgglgiihknmsieqqaeqvdkvkrsggllv
gaavgvtadamtridalvkasvdaivldtahghsqgvidkvkevrakypslniiagnvat
aeatkalieaganvvkvgigpgsicttrvvagvgvpqltavydcatearkhgipviadgg
ikysgdmvkalaagahvvmlgsmfagvaespgeteiyqgrqfkvyrgmgsvgamekgskd
ryfqegnkklvpegiegrvpykgpladtvhqlvgglragmgycgaqdleflrenaqfirm
sgaglleshphhvqitkeapnysl

    Sequence, based on observed residues (ATOM records): (download) 
    >4myxE (E:)
qsnamweskfvkegltfddvllvpaksdvlprevsvktvlseslqlniplisagmdtvte
admaiamarqgglgiihknmsieqqaeqvdkvkrsggllvgaavgvtadamtridalvka
svdaivldtahghsqgvidkvkevrakypslniiagnvataeatkalieaganvvkvgig
pgsicttrvvagvgvpqltavydcatearkhgipviadggikysgdmvkalaagahvvml
gsmfagvaespgeteiyqgrqfkvyrgmgsvgamekgklvpegiegrvpykgpladtvhq
lvgglragmgycgaqdleflrenaqfirmsgaglleshphhvqitkeapnys

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >4myxF (F:)
mhhhhhhssgvdlgtenlyfqsnamweskfvkegltfddvllvpaksdvlprevsvktvl
seslqlniplisagmdtvteadmaiamarqgglgiihknmsieqqaeqvdkvkrsggllv
gaavgvtadamtridalvkasvdaivldtahghsqgvidkvkevrakypslniiagnvat
aeatkalieaganvvkvgigpgsicttrvvagvgvpqltavydcatearkhgipviadgg
ikysgdmvkalaagahvvmlgsmfagvaespgeteiyqgrqfkvyrgmgsvgamekgskd
ryfqegnkklvpegiegrvpykgpladtvhqlvgglragmgycgaqdleflrenaqfirm
sgaglleshphhvqitkeapnysl

    Sequence, based on observed residues (ATOM records): (download) 
    >4myxF (F:)
snamweskfvkegltfddvllvpaksdvlprevsvktvlseslqlniplisagmdtvtea
dmaiamarqgglgiihknmsieqqaeqvdkvkrsggllvgaavgvtadamtridalvkas
vdaivldtahghsqgvidkvkevrakypslniiagnvataeatkalieaganvvkvgigp
gsicttrvvagvgvpqltavydcatearkhgipviadggikysgdmvkalaagahvvmlg
smfagvaespgeteiyqgrqfkvyrgmgsvgamekklvpegiegrvpykgpladtvhqlv
gglragmgycgaqdleflrenaqfirmsgaglleshphhvqitkeapnys

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >4myxG (G:)
mhhhhhhssgvdlgtenlyfqsnamweskfvkegltfddvllvpaksdvlprevsvktvl
seslqlniplisagmdtvteadmaiamarqgglgiihknmsieqqaeqvdkvkrsggllv
gaavgvtadamtridalvkasvdaivldtahghsqgvidkvkevrakypslniiagnvat
aeatkalieaganvvkvgigpgsicttrvvagvgvpqltavydcatearkhgipviadgg
ikysgdmvkalaagahvvmlgsmfagvaespgeteiyqgrqfkvyrgmgsvgamekgskd
ryfqegnkklvpegiegrvpykgpladtvhqlvgglragmgycgaqdleflrenaqfirm
sgaglleshphhvqitkeapnysl

    Sequence, based on observed residues (ATOM records): (download) 
    >4myxG (G:)
fqsnamweskfvkegltfddvllvpaksdvlprevsvktvlseslqlniplisagmdtvt
eadmaiamarqgglgiihknmsieqqaeqvdkvkrsggllvgaavgvtadamtridalvk
asvdaivldtahghsqgvidkvkevrakypslniiagnvataeatkalieaganvvkvgi
gpgsicttrvvagvgvpqltavydcatearkhgipviadggikysgdmvkalaagahvvm
lgsmfagvaespgeteiyqgrqfkvyrgmgsvgamekgskkklvpegiegrvpykgplad
tvhqlvgglragmgycgaqdleflrenaqfirmsgaglleshphhvqitkeapnys

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >4myxH (H:)
mhhhhhhssgvdlgtenlyfqsnamweskfvkegltfddvllvpaksdvlprevsvktvl
seslqlniplisagmdtvteadmaiamarqgglgiihknmsieqqaeqvdkvkrsggllv
gaavgvtadamtridalvkasvdaivldtahghsqgvidkvkevrakypslniiagnvat
aeatkalieaganvvkvgigpgsicttrvvagvgvpqltavydcatearkhgipviadgg
ikysgdmvkalaagahvvmlgsmfagvaespgeteiyqgrqfkvyrgmgsvgamekgskd
ryfqegnkklvpegiegrvpykgpladtvhqlvgglragmgycgaqdleflrenaqfirm
sgaglleshphhvqitkeapnysl

    Sequence, based on observed residues (ATOM records): (download) 
    >4myxH (H:)
snamweskfvkegltfddvllvpaksdvlprevsvktvlseslqlniplisagmdtvtea
dmaiamarqgglgiihknmsieqqaeqvdkvkrsggllvgaavgvtadamtridalvkas
vdaivldtahghsqgvidkvkevrakypslniiagnvataeatkalieaganvvkvgigp
gsicttrvvagvgvpqltavydcatearkhgipviadggikysgdmvkalaagahvvmlg
smfagvaespgeteiyqgrqfkvyrgmgsvgamekklvpegiegrvpykgpladtvhqlv
gglragmgycgaqdleflrenaqfirmsgaglleshphhvqitkeapnys