PDB entry 4mxy

View 4mxy on RCSB PDB site
Description: Src M314L T338M double mutant bound to kinase inhibitor bosutinib
Class: transferase/transferase inhibitor
Keywords: Kinase, Phosphorylation, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2013-09-26, released 2013-12-25
The last revision prior to the SCOPe 2.07 freeze date was dated 2014-02-05, with a file datestamp of 2014-01-31.
Experiment type: XRAY
Resolution: 2.58 Å
R-factor: 0.211
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Proto-oncogene tyrosine-protein kinase Src
    Species: Homo sapiens [TaxId:9606]
    Gene: SRC, SRC1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P12931 (Start-285)
      • engineered mutation (66)
      • engineered mutation (90)
    Domains in SCOPe 2.07: d4mxya_
  • Chain 'B':
    Compound: Proto-oncogene tyrosine-protein kinase Src
    Species: Homo sapiens [TaxId:9606]
    Gene: SRC, SRC1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P12931 (Start-285)
      • engineered mutation (66)
      • engineered mutation (90)
    Domains in SCOPe 2.07: d4mxyb_
  • Heterogens: DB8, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4mxyA (A:)
ghmqtqglakdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaf
lqeaqvlkklrheklvqlyavvseepiyivmeymskgslldflkgetgkylrlpqlvdma
aqiasgmayvermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpik
wtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppec
peslhdlmcqcwrkepeerptfeylqafledyftstepqyqpgenl

    Sequence, based on observed residues (ATOM records): (download) 
    >4mxyA (A:)
kdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaflqeaqvlkk
lrheklvqlyavvseepiyivmeymskgslldflkgetgkylrlpqlvdmaaqiasgmay
vermnyvhrdlraanilvgenlvckvadfglarliefpikwtapeaalygrftiksdvws
fgilltelttkgrvpypgmvnrevldqvergyrmpcppecpeslhdlmcqcwrkepeerp
tfeylqafledyftstepqyqpgenl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4mxyB (B:)
ghmqtqglakdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaf
lqeaqvlkklrheklvqlyavvseepiyivmeymskgslldflkgetgkylrlpqlvdma
aqiasgmayvermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpik
wtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppec
peslhdlmcqcwrkepeerptfeylqafledyftstepqyqpgenl

    Sequence, based on observed residues (ATOM records): (download) 
    >4mxyB (B:)
daweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaflqeaqvlkkl
rheklvqlyavvseepiyivmeymskgslldflkgetgkylrlpqlvdmaaqiasgmayv
ermnyvhrdlraanilvgenlvckvadfglarlifpikwtapeaalygrftiksdvwsfg
illtelttkgrvpypgmvnrevldqvergyrmpcppecpeslhdlmcqcwrkepeerptf
eylqafledyftstepqyqpgenl