PDB entry 4mvk

View 4mvk on RCSB PDB site
Description: crystal structure of an engineered lipocalin (anticalin us7) in complex with the alzheimer amyloid peptide fragment vffaed
Deposited on 2013-09-24, released 2015-08-12
The last revision was dated 2016-06-15, with a file datestamp of 2016-06-10.
Experiment type: XRAY
Resolution: 1.5 Å
R-factor: N/A
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Neutrophil gelatinase-associated lipocalin
    Species: Homo sapiens [TaxId:9606]
    Gene: engineered variant US7, HNL, LCN2, LCN2 (NGAL_HUMAN), NGAL
    Database cross-references and differences (RAF-indexed):
    • Uniprot P80188
      • engineered mutation (27)
      • engineered mutation (35)
      • engineered mutation (39-40)
      • engineered mutation (48)
      • engineered mutation (69)
      • engineered mutation (71-72)
      • engineered mutation (76)
      • engineered mutation (78)
      • engineered mutation (86)
      • engineered mutation (95)
      • engineered mutation (99)
      • engineered mutation (102)
      • engineered mutation (105)
      • engineered mutation (124)
      • engineered mutation (126)
      • engineered mutation (131)
      • engineered mutation (133)
  • Chain 'B':
    Compound: Amyloid peptide fragment VFFAED
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >4mvkA (A:)
    qdstsdlipapplskvplqqnfqdnqfhgkwyvvgvagnkslredkdpwkmyatiyelke
    dksynvtsvgfgtkkchykirtfvpgsqpgeftlgriksrpgrtsalvrvvstnynqham
    vffkvvqqnresfnitlygrtkeltselkenfirfskslglpenhivfpvpidqcidgsa
    wshpqfek
    

    Sequence, based on observed residues (ATOM records):
    >4mvkA (A:)
    lipapplskvplqqnfqdnqfhgkwyvvgvagnkslredkdpwkmyatiyelkedksynv
    tsvgfgtkkchykirtfvpgsqpgeftlgriksrpgrtsalvrvvstnynqhamvffkvv
    qqnresfnitlygrtkeltselkenfirfskslglpenhivfpvpidqcid
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records:
    >4mvkB (B:)
    vffaed