PDB entry 4muw

View 4muw on RCSB PDB site
Description: Crystal Structure of PDE10A with Novel Keto-Benzimidazole Inhibitor
Class: hydrolase/hydrolase inhibitor
Keywords: PDE10A, phosphodiesterase 10A, inhibitors, Keto-Benzimidazoles, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2013-09-23, released 2013-10-23
The last revision prior to the SCOPe 2.07 freeze date was dated 2014-01-15, with a file datestamp of 2014-01-10.
Experiment type: XRAY
Resolution: 2.64 Å
R-factor: 0.172
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE10A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4muwa_
  • Chain 'B':
    Compound: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE10A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4muwb_
  • Heterogens: ZN, SO4, GOL, 2F4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4muwA (A:)
    mkhhhhhhhdevdtseewqglmqftlpvrlckeielfhfdigpfenmwpgifvymvhrsc
    gtscfeleklcrfimsvkknyrrvpyhnwkhavtvahcmyailqnnhtlftdlerkglli
    aclchdldhrgfsnsylqkfdhplaalyststmeqhhfsqtvsilqleghnifstlssse
    yeqvleiirkaiiatdlalyfgnrkqleemyqtgslnlnnqshrdrviglmmtacdlcsv
    tklwpvtkltandiyaefwaegdemkklgiqpipmmdrdkkdevpqgqlgfynavaipcy
    ttltqilpptepllkacrdnlsqwekvirgeetatwisspsvaqkaaased
    

    Sequence, based on observed residues (ATOM records): (download)
    >4muwA (A:)
    tseewqglmqftlpvrlckeielfhfdigpfenmwpgifvymvhrscgtscfeleklcrf
    imsvkknyrrvpyhnwkhavtvahcmyailqnnhtlftdlerkglliaclchdldhrgfs
    nsylqkfdhplaalyststmeqhhfsqtvsilqleghnifstlssseyeqvleiirkaii
    atdlalyfgnrkqleemyqtgslnlnnqshrdrviglmmtacdlcsvtklwpvtkltand
    iyaefwaegdemkklgiqpipmmdrdkkdevpqgqlgfynavaipcyttltqilpptepl
    lkacrdnlsqwekvirge
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4muwB (B:)
    mkhhhhhhhdevdtseewqglmqftlpvrlckeielfhfdigpfenmwpgifvymvhrsc
    gtscfeleklcrfimsvkknyrrvpyhnwkhavtvahcmyailqnnhtlftdlerkglli
    aclchdldhrgfsnsylqkfdhplaalyststmeqhhfsqtvsilqleghnifstlssse
    yeqvleiirkaiiatdlalyfgnrkqleemyqtgslnlnnqshrdrviglmmtacdlcsv
    tklwpvtkltandiyaefwaegdemkklgiqpipmmdrdkkdevpqgqlgfynavaipcy
    ttltqilpptepllkacrdnlsqwekvirgeetatwisspsvaqkaaased
    

    Sequence, based on observed residues (ATOM records): (download)
    >4muwB (B:)
    lpvrlckeielfhfdigpfenmwpgifvymvhrscgtscfeleklcrfimsvkknyrrvp
    yhnwkhavtvahcmyailqnnhtlftdlerkglliaclchdldhrgfsnsylqkfdhpla
    alyststmeqhhfsqtvsilqleghnifstlssseyeqvleiirkaiiatdlalyfgnrk
    qleemyqtgslnlnnqshrdrviglmmtacdlcsvtklwpvtkltandiyaefwaegdem
    kklgiqpipmmdrdkkdevpqgqlgfynavaipcyttltqilpptepllkacrdnlsqwe
    kvirge