PDB entry 4mri

View 4mri on RCSB PDB site
Description: Human brain aspartoacylase mutant F295S complex with intermediate analog (N-phosphonomethyl-L-aspartate)
Class: hydrolase
Keywords: Canavan disease, N-acetyl-L-aspartate, Zinc-dependent hydrolase, aspartoacylase family, aminoacylase-2, HYDROLASE
Deposited on 2013-09-17, released 2014-07-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-15, with a file datestamp of 2017-11-10.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Aspartoacylase
    Species: Homo sapiens [TaxId:9606]
    Gene: ACY2, ASP, ASPA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P45381
      • engineered mutation (294)
    Domains in SCOPe 2.08: d4mria_
  • Chain 'B':
    Compound: Aspartoacylase
    Species: Homo sapiens [TaxId:9606]
    Gene: ACY2, ASP, ASPA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P45381
      • engineered mutation (294)
    Domains in SCOPe 2.08: d4mrib_
  • Heterogens: ZN, AS9, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4mriA (A:)
mtschiaeehiqkvaifggthgneltgvflvkhwlengaeiqrtglevkpfitnpravkk
ctryidcdlnrifdlenlgkkmsedlpyevrraqeinhlfgpkdsedsydiifdlhntts
nmgctliledsrnnfliqmfhyiktslaplpcyvyliehpslkyattrsiakypvgievg
pqpqgvlradildqmrkmikhaldfihhfnegkefppcaievykiiekvdyprdengeia
aiihpnlqdqdwkplhpgdpmfltldgktiplggdctvypvfvneaayyekkeasakttk
ltlnaksircclh

    Sequence, based on observed residues (ATOM records): (download) 
    >4mriA (A:)
hiqkvaifggthgneltgvflvkhwlengaeiqrtglevkpfitnpravkkctryidcdl
nrifdlenlgkkmsedlpyevrraqeinhlfgpkdsedsydiifdlhnttsnmgctlile
dsrnnfliqmfhyiktslaplpcyvyliehpslkyattrsiakypvgievgpqpqgvlra
dildqmrkmikhaldfihhfnegkefppcaievykiiekvdyprdengeiaaiihpnlqd
qdwkplhpgdpmfltldgktiplggdctvypvfvneaayyekkeasakttkltlnaksir
cc

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4mriB (B:)
mtschiaeehiqkvaifggthgneltgvflvkhwlengaeiqrtglevkpfitnpravkk
ctryidcdlnrifdlenlgkkmsedlpyevrraqeinhlfgpkdsedsydiifdlhntts
nmgctliledsrnnfliqmfhyiktslaplpcyvyliehpslkyattrsiakypvgievg
pqpqgvlradildqmrkmikhaldfihhfnegkefppcaievykiiekvdyprdengeia
aiihpnlqdqdwkplhpgdpmfltldgktiplggdctvypvfvneaayyekkeasakttk
ltlnaksircclh

    Sequence, based on observed residues (ATOM records): (download) 
    >4mriB (B:)
ehiqkvaifggthgneltgvflvkhwlengaeiqrtglevkpfitnpravkkctryidcd
lnrifdlenlgkkmsedlpyevrraqeinhlfgpkdsedsydiifdlhnttsnmgctlil
edsrnnfliqmfhyiktslaplpcyvyliehpslkyattrsiakypvgievgpqpqgvlr
adildqmrkmikhaldfihhfnegkefppcaievykiiekvdyprdengeiaaiihpnlq
dqdwkplhpgdpmfltldgktiplggdctvypvfvneaayyekkeasakttkltlnaksi
rcc