PDB entry 4mr5

View 4mr5 on RCSB PDB site
Description: Crystal Structure of the second bromodomain of human BRD2 in complex with a quinazolinone ligand (RVX-OH)
Class: TRANSCRIPTION/TRANSCRIPTION inhibitor
Keywords: BRD2, RING3, Small molecule inhibitor, RVX-OH, inhibitor complex, Structural Genomics Consortium, SGC, TRANSCRIPTION-TRANSCRIPTION inhibitor complex
Deposited on 2013-09-17, released 2013-11-27
The last revision prior to the SCOPe 2.06 freeze date was dated 2014-01-22, with a file datestamp of 2014-01-17.
Experiment type: XRAY
Resolution: 1.63 Å
R-factor: 0.137
AEROSPACI score: 0.55 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bromodomain-containing protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD2, KIAA9001, RING3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4mr5a_
  • Heterogens: EDO, DMS, 1K0, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4mr5A (A:)
smgklseqlkhcngilkellskkhaayawpfykpvdasalglhdyhdiikhpmdlstvkr
kmenrdyrdaqefaadvrlmfsncykynppdhdvvamarklqdvfefryakmpd

    Sequence, based on observed residues (ATOM records): (download) 
    >4mr5A (A:)
lseqlkhcngilkellskkhaayawpfykpvdasalglhdyhdiikhpmdlstvkrkmen
rdyrdaqefaadvrlmfsncykynppdhdvvamarklqdvfefryakmpd