PDB entry 4mr3

View 4mr3 on RCSB PDB site
Description: Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazolinone ligand (RVX-OH)
Class: TRANSCRIPTION/TRANSCRIPTION inhibitor
Keywords: BRD4, CAP, HUNK1, MCAP, Mitotic chromosome associated protein, BRD, Small molecule inhibitor, RVX-OH, Structural Genomics Consortium, SGC, TRANSCRIPTION-TRANSCRIPTION inhibitor complex
Deposited on 2013-09-17, released 2013-11-27
The last revision prior to the SCOPe 2.03 freeze date was dated 2013-11-27, with a file datestamp of 2013-11-22.
Experiment type: XRAY
Resolution: 1.68 Å
R-factor: 0.142
AEROSPACI score: 0.53 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Bromodomain-containing protein 4
  Species: Homo sapiens [TaxId:9606]
  Gene: BRD4, HUNK1
  Database cross-references and differences (RAF-indexed):
  • Uniprot O60885 (2-126)
    • expression tag (0-1)
  Domains in SCOPe 2.03: d4mr3a_
• Heterogens: EDO, 1K0, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >4mr3A (A:)
  smnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykii
  ktpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqki
  nelptee