PDB entry 4mqw

View 4mqw on RCSB PDB site
Description: Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor (P31)
Class: signaling protein
Keywords: cystine-knot, leucine-rich repeats, Glycoprotein hormone, GPCR, Sulfation, SIGNALING PROTEIN
Deposited on 2013-09-16, released 2014-04-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: glycoprotein hormones, alpha polypeptide
    Species: Homo sapiens [TaxId:9606]
    Gene: CGA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4mqwa_
  • Chain 'B':
    Compound: follitropin subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: FSHB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4mqwb_
  • Chain 'D':
    Compound: glycoprotein hormones, alpha polypeptide
    Species: Homo sapiens [TaxId:9606]
    Gene: CGA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4mqwd_
  • Chain 'E':
    Compound: follitropin subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: FSHB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4mqwe_
  • Chain 'G':
    Compound: glycoprotein hormones, alpha polypeptide
    Species: Homo sapiens [TaxId:9606]
    Gene: CGA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4mqwg_
  • Chain 'H':
    Compound: follitropin subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: FSHB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4mqwh_
  • Chain 'X':
    Compound: follicle-stimulating hormone receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: FSHR, LGR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P23945
      • engineered mutation (172)
  • Chain 'Y':
    Compound: follicle-stimulating hormone receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: FSHR, LGR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P23945
      • engineered mutation (172)
  • Chain 'Z':
    Compound: follicle-stimulating hormone receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: FSHR, LGR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P23945
      • engineered mutation (172)
  • Heterogens: NAG, EDO, JEF, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4mqwA (A:)
apdvqdcpectlqenplfsqpgapilqcmgccfsrayptplrskktmlvqknvtsestcc
vaksynrvtvmggfkvenhtachcstcyyhksaaahhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4mqwA (A:)
qdcpectlqenplfsqpgapilqcmgccfsrayptplrskktmlvqknvtsestccvaks
ynrvtvmggfkvenhtachcstcyyhks

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4mqwB (B:)
nsceltnitiaiekeecrfcisinttwcagycytrdlvykdparpkiqktctfkelvyet
vrvpgcahhadslytypvatqchcgkcdsdstdctvrglgpsycsfgemke

    Sequence, based on observed residues (ATOM records): (download) 
    >4mqwB (B:)
nsceltnitiaiekeecrfcisinttwcagycytrdlvykdparpkiqktctfkelvyet
vrvpgcahhadslytypvatqchcgkcdsdstdctvrglgpsycsfgem

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4mqwD (D:)
apdvqdcpectlqenplfsqpgapilqcmgccfsrayptplrskktmlvqknvtsestcc
vaksynrvtvmggfkvenhtachcstcyyhksaaahhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4mqwD (D:)
vqdcpectlqenplfsqpgapilqcmgccfsrayptplrskktmlvqknvtsestccvak
synrvtvmggfkvenhtachcstcyyhks

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4mqwE (E:)
nsceltnitiaiekeecrfcisinttwcagycytrdlvykdparpkiqktctfkelvyet
vrvpgcahhadslytypvatqchcgkcdsdstdctvrglgpsycsfgemke

    Sequence, based on observed residues (ATOM records): (download) 
    >4mqwE (E:)
nsceltnitiaiekeecrfcisinttwcagycytrdlvykdparpkiqktctfkelvyet
vrvpgcahhadslytypvatqchcgkcdsdstdctvrglgpsycsfge

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >4mqwG (G:)
apdvqdcpectlqenplfsqpgapilqcmgccfsrayptplrskktmlvqknvtsestcc
vaksynrvtvmggfkvenhtachcstcyyhksaaahhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4mqwG (G:)
qdcpectlqenplfsqpgapilqcmgccfsrayptplrskktmlvqknvtsestccvaks
ynrvtvmggfkvenhtachcstcyyhks

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >4mqwH (H:)
nsceltnitiaiekeecrfcisinttwcagycytrdlvykdparpkiqktctfkelvyet
vrvpgcahhadslytypvatqchcgkcdsdstdctvrglgpsycsfgemke

    Sequence, based on observed residues (ATOM records): (download) 
    >4mqwH (H:)
nsceltnitiaiekeecrfcisinttwcagycytrdlvykdparpkiqktctfkelvyet
vrvpgcahhadslytypvatqchcgkcdsdstdctvrglgpsycsfge

  • Chain 'X':
    No sequence available.

  • Chain 'Y':
    No sequence available.

  • Chain 'Z':
    No sequence available.