PDB entry 4mqk

View 4mqk on RCSB PDB site
Description: Carbonmonoxy Structure of the Human Fetal Hemoglobin Mutant HbF Toms River alphawtgammaV67M
Class: oxygen transport
Keywords: oxygen-transport, autooxidation, OXYGEN TRANSPORT
Deposited on 2013-09-16, released 2013-10-30
The last revision prior to the SCOPe 2.05 freeze date was dated 2014-10-08, with a file datestamp of 2014-10-03.
Experiment type: XRAY
Resolution: 2.24 Å
R-factor: 0.177
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Hemoglobin subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: HBA1, HBA2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4mqka_
  • Chain 'B':
    Compound: Hemoglobin subunit gamma-2
    Species: Homo sapiens [TaxId:9606]
    Gene: HBB, HBG2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P69892 (Start-145)
      • engineered mutation (66)
    Domains in SCOPe 2.05: d4mqkb_
  • Chain 'C':
    Compound: Hemoglobin subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: HBA1, HBA2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4mqkc_
  • Chain 'D':
    Compound: Hemoglobin subunit gamma-2
    Species: Homo sapiens [TaxId:9606]
    Gene: HBB, HBG2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P69892 (Start-145)
      • engineered mutation (66)
    Domains in SCOPe 2.05: d4mqkd_
  • Chain 'E':
    Compound: Hemoglobin subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: HBA1, HBA2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4mqke_
  • Chain 'F':
    Compound: Hemoglobin subunit gamma-2
    Species: Homo sapiens [TaxId:9606]
    Gene: HBB, HBG2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P69892 (Start-145)
      • engineered mutation (66)
    Domains in SCOPe 2.05: d4mqkf_
  • Chain 'G':
    Compound: Hemoglobin subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: HBA1, HBA2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4mqkg_
  • Chain 'H':
    Compound: Hemoglobin subunit gamma-2
    Species: Homo sapiens [TaxId:9606]
    Gene: HBB, HBG2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P69892 (Start-145)
      • engineered mutation (66)
    Domains in SCOPe 2.05: d4mqkh_
  • Heterogens: HEM, CMO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4mqkA (A:)
    vlspadktnvkaawgkvgahageygaealermflsfpttktyfphfdlshgsaqvkghgk
    kvadaltnavahvddmpnalsalsdlhahklrvdpvnfkllshcllvtlaahlpaeftpa
    vhasldkflasvstvltskyr
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4mqkB (B:)
    ghfteedkatitslwgkvnvedaggetlgrllvvypwtqrffdsfgnlssasaimgnpkv
    kahgkkmltslgdaikhlddlkgtfaqlselhcdklhvdpenfkllgnvlvtvlaihfgk
    eftpevqaswqkmvtgvasalssryh
    

    Sequence, based on observed residues (ATOM records): (download)
    >4mqkB (B:)
    hfteedkatitslwgkvnvedaggetlgrllvvypwtqrffdsfgnlssasaimgnpkvk
    ahgkkmltslgdaikhlddlkgtfaqlselhcdklhvdpenfkllgnvlvtvlaihfgke
    ftpevqaswqkmvtgvasalssryh
    

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4mqkC (C:)
    vlspadktnvkaawgkvgahageygaealermflsfpttktyfphfdlshgsaqvkghgk
    kvadaltnavahvddmpnalsalsdlhahklrvdpvnfkllshcllvtlaahlpaeftpa
    vhasldkflasvstvltskyr
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >4mqkD (D:)
    ghfteedkatitslwgkvnvedaggetlgrllvvypwtqrffdsfgnlssasaimgnpkv
    kahgkkmltslgdaikhlddlkgtfaqlselhcdklhvdpenfkllgnvlvtvlaihfgk
    eftpevqaswqkmvtgvasalssryh
    

    Sequence, based on observed residues (ATOM records): (download)
    >4mqkD (D:)
    hfteedkatitslwgkvnvedaggetlgrllvvypwtqrffdsfgnlssasaimgnpkvk
    ahgkkmltslgdaikhlddlkgtfaqlselhcdklhvdpenfkllgnvlvtvlaihfgke
    ftpevqaswqkmvtgvasalssryh
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >4mqkE (E:)
    vlspadktnvkaawgkvgahageygaealermflsfpttktyfphfdlshgsaqvkghgk
    kvadaltnavahvddmpnalsalsdlhahklrvdpvnfkllshcllvtlaahlpaeftpa
    vhasldkflasvstvltskyr
    

    Sequence, based on observed residues (ATOM records): (download)
    >4mqkE (E:)
    vlspadktnvkaawgkvgahageygaealermflsfpttktyfphfdlshgsaqvkghgk
    kvadaltnavahvddmpnalsalsdlhahklrvdpvnfkllshcllvtlaahlpaeftpa
    vhasldkflasvstvlts
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >4mqkF (F:)
    ghfteedkatitslwgkvnvedaggetlgrllvvypwtqrffdsfgnlssasaimgnpkv
    kahgkkmltslgdaikhlddlkgtfaqlselhcdklhvdpenfkllgnvlvtvlaihfgk
    eftpevqaswqkmvtgvasalssryh
    

    Sequence, based on observed residues (ATOM records): (download)
    >4mqkF (F:)
    hfteedkatitslwgkvnvedaggetlgrllvvypwtqrffdsfgnlssasaimgnpkvk
    ahgkkmltslgdaikhlddlkgtfaqlselhcdklhvdpenfkllgnvlvtvlaihfgke
    ftpevqaswqkmvtgvasalssryh
    

  • Chain 'G':
    Sequence, based on SEQRES records: (download)
    >4mqkG (G:)
    vlspadktnvkaawgkvgahageygaealermflsfpttktyfphfdlshgsaqvkghgk
    kvadaltnavahvddmpnalsalsdlhahklrvdpvnfkllshcllvtlaahlpaeftpa
    vhasldkflasvstvltskyr
    

    Sequence, based on observed residues (ATOM records): (download)
    >4mqkG (G:)
    vlspadktnvkaawgkvgahageygaealermflsfpttktyfphfdlshgsaqvkghgk
    kvadaltnavahvddmpnalsalsdlhahklrvdpvnfkllshcllvtlaahlpaeftpa
    vhasldkflasvstvltsky
    

  • Chain 'H':
    Sequence, based on SEQRES records: (download)
    >4mqkH (H:)
    ghfteedkatitslwgkvnvedaggetlgrllvvypwtqrffdsfgnlssasaimgnpkv
    kahgkkmltslgdaikhlddlkgtfaqlselhcdklhvdpenfkllgnvlvtvlaihfgk
    eftpevqaswqkmvtgvasalssryh
    

    Sequence, based on observed residues (ATOM records): (download)
    >4mqkH (H:)
    hfteedkatitslwgkvnvedaggetlgrllvvypwtqrffdsfgnlssasaimgnpkvk
    ahgkkmltslgdaikhlddlkgtfaqlselhcdklhvdpenfkllgnvlvtvlaihfgke
    ftpevqaswqkmvtgvasalssryh