PDB entry 4mp2

View 4mp2 on RCSB PDB site
Description: Crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor PA1
Class: Transferase/Transferase Inhibitor
Keywords: GHKL protein kinase, pyruvate dehydrogenase complex, Mitochondrial protein kinases, Impaired glucose oxidation, Hepatic steatosis, Type 2 diabetes, Cancer, Bergerat nucleotide-binding fold, protein kinase, Transferase-Transferase Inhibitor complex
Deposited on 2013-09-12, released 2014-01-01
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-03-05, with a file datestamp of 2014-02-28.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: 0.204
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PDK2, PDHK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4mp2a1, d4mp2a2
  • Heterogens: PV1, TLA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4mp2A (A:)
sknaslagapkyiehfskfspsplsmkqfldfgssnacektsftflrqelpvrlanimke
inllpdrvlstpsvqlvqswyvqslldimefldkdpedhrtlsqftdalvtirnrhndvv
ptmaqgvleykdtygddpvsnqniqyfldrfylsrisirmlinqhtlifdgstnpahpkh
igsidpncnvsevvkdaydmakllcdkyymaspdleiqeinaanskqpihmvyvpshlyh
mlfelfknamratveshesslilppikvmvalgeedlsikmsdrgggvplrkierlfsym
ystaptpqpgtggtplagfgyglpisrlyakyfqgdlqlfsmegfgtdaviylkalstds
verlpvynksawrhyqtiqeagdwcvpstepkntstyrvs

    Sequence, based on observed residues (ATOM records): (download) 
    >4mp2A (A:)
slagapkyiehfskfspsplsmkqfldfgssnacektsftflrqelpvrlanimkeinll
pdrvlstpsvqlvqswyvqslldimefldkdpedhrtlsqftdalvtirnrhndvvptma
qgvleykdtygddpvsnqniqyfldrfylsrisirmlinqhtlifdpahpkhigsidpnc
nvsevvkdaydmakllcdkyymaspdleiqeinaanskqpihmvyvpshlyhmlfelfkn
amratveshesslilppikvmvalgeedlsikmsdrgggvplrkierlfsymysgyglpi
srlyakyfqgdlqlfsmegfgtdaviylkalstdsverlpvynksawrhyqtiqeagdwc