PDB entry 4mnf
View 4mnf on RCSB PDB site
Description: Crystal structure of BRAF-V600E bound to GDC0879
Class: transferase/transferase inhibitor
Keywords: RAF, MAPK, kinase domain, ATP-binding, ERK, RAS, PAK, active conformation, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on
2013-09-10, released
2014-06-18
The last revision prior to the SCOPe 2.08 freeze date was dated
2014-09-24, with a file datestamp of
2014-09-19.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.215
AEROSPACI score: 0.2
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Serine/threonine-protein kinase B-raf
Species: Homo sapiens [TaxId:9606]
Gene: BRAF, BRAF1, RAFB1
Database cross-references and differences (RAF-indexed):
- Uniprot P15056
- engineered mutation (192)
Domains in SCOPe 2.08: d4mnfa_ - Chain 'B':
Compound: Serine/threonine-protein kinase B-raf
Species: Homo sapiens [TaxId:9606]
Gene: BRAF, BRAF1, RAFB1
Database cross-references and differences (RAF-indexed):
- Uniprot P15056
- engineered mutation (192)
Domains in SCOPe 2.08: d4mnfb_ - Heterogens: 29L, CL, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4mnfA (A:)
msgahhhhhhhhggggglvprgamsedrnrmktlgrrdssddweipdgqitvgqrigsgs
fgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrktrhvnillfmgystkpqlai
vtqwcegsslyhhlhiietkfemiklidiarqtaqgmdylhaksiihrdlksnniflhed
ltvkigdfglateksrwsgshqfeqlsgsilwmapevirmqdknpysfqsdvyafgivly
elmtgqlpysninnrdqiifmvgrgylspdlskvrsncpkamkrlmaeclkkkrderplf
pqilasiellarslpkihrsasepslnra
Sequence, based on observed residues (ATOM records): (download)
>4mnfA (A:)
dweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrkt
rhvnillfmgystkpqlaivtqwcegsslyhhlhiietkfemiklidiarqtaqgmdylh
aksiihrdlksnniflhedltvkigdfglatesilwmapevirmqdknpysfqsdvyafg
ivlyelmtgqlpysninnrdqiifmvgrgylspdlskvrsncpkamkrlmaeclkkkrde
rplfpqilasiellars
- Chain 'B':
Sequence, based on SEQRES records: (download)
>4mnfB (B:)
msgahhhhhhhhggggglvprgamsedrnrmktlgrrdssddweipdgqitvgqrigsgs
fgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrktrhvnillfmgystkpqlai
vtqwcegsslyhhlhiietkfemiklidiarqtaqgmdylhaksiihrdlksnniflhed
ltvkigdfglateksrwsgshqfeqlsgsilwmapevirmqdknpysfqsdvyafgivly
elmtgqlpysninnrdqiifmvgrgylspdlskvrsncpkamkrlmaeclkkkrderplf
pqilasiellarslpkihrsasepslnra
Sequence, based on observed residues (ATOM records): (download)
>4mnfB (B:)
dweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrkt
rhvnillfmgystkpqlaivtqwcegsslyhhlhiietkfemiklidiarqtaqgmdylh
aksiihrdlksnniflhedltvkigdfglatesilwmapevirmqdknpysfqsdvyafg
ivlyelmtgqlpysninnrdqiifmvgrgylspdlskvrsncpkamkrlmaeclkkkrde
rplfpqilasiellars