PDB entry 4mnf

View 4mnf on RCSB PDB site
Description: Crystal structure of BRAF-V600E bound to GDC0879
Class: transferase/transferase inhibitor
Keywords: RAF, MAPK, kinase domain, ATP-binding, ERK, RAS, PAK, active conformation, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2013-09-10, released 2014-06-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-09-24, with a file datestamp of 2014-09-19.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.215
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein kinase B-raf
    Species: Homo sapiens [TaxId:9606]
    Gene: BRAF, BRAF1, RAFB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P15056
      • engineered mutation (192)
    Domains in SCOPe 2.08: d4mnfa_
  • Chain 'B':
    Compound: Serine/threonine-protein kinase B-raf
    Species: Homo sapiens [TaxId:9606]
    Gene: BRAF, BRAF1, RAFB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P15056
      • engineered mutation (192)
    Domains in SCOPe 2.08: d4mnfb_
  • Heterogens: 29L, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4mnfA (A:)
msgahhhhhhhhggggglvprgamsedrnrmktlgrrdssddweipdgqitvgqrigsgs
fgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrktrhvnillfmgystkpqlai
vtqwcegsslyhhlhiietkfemiklidiarqtaqgmdylhaksiihrdlksnniflhed
ltvkigdfglateksrwsgshqfeqlsgsilwmapevirmqdknpysfqsdvyafgivly
elmtgqlpysninnrdqiifmvgrgylspdlskvrsncpkamkrlmaeclkkkrderplf
pqilasiellarslpkihrsasepslnra

    Sequence, based on observed residues (ATOM records): (download) 
    >4mnfA (A:)
dweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrkt
rhvnillfmgystkpqlaivtqwcegsslyhhlhiietkfemiklidiarqtaqgmdylh
aksiihrdlksnniflhedltvkigdfglatesilwmapevirmqdknpysfqsdvyafg
ivlyelmtgqlpysninnrdqiifmvgrgylspdlskvrsncpkamkrlmaeclkkkrde
rplfpqilasiellars

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4mnfB (B:)
msgahhhhhhhhggggglvprgamsedrnrmktlgrrdssddweipdgqitvgqrigsgs
fgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrktrhvnillfmgystkpqlai
vtqwcegsslyhhlhiietkfemiklidiarqtaqgmdylhaksiihrdlksnniflhed
ltvkigdfglateksrwsgshqfeqlsgsilwmapevirmqdknpysfqsdvyafgivly
elmtgqlpysninnrdqiifmvgrgylspdlskvrsncpkamkrlmaeclkkkrderplf
pqilasiellarslpkihrsasepslnra

    Sequence, based on observed residues (ATOM records): (download) 
    >4mnfB (B:)
dweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrkt
rhvnillfmgystkpqlaivtqwcegsslyhhlhiietkfemiklidiarqtaqgmdylh
aksiihrdlksnniflhedltvkigdfglatesilwmapevirmqdknpysfqsdvyafg
ivlyelmtgqlpysninnrdqiifmvgrgylspdlskvrsncpkamkrlmaeclkkkrde
rplfpqilasiellars