PDB entry 4mlu

View 4mlu on RCSB PDB site
Description: Peptides Containing Mono-anionic Phosphothreonine Esters That Exhibit High Plk1 Polo-box Domain-binding Affinities and Potent Antiproliferative Effects in HeLa Cells
Class: transferase/transferase inhibitor
Keywords: phospho-peptide binding domain, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2013-09-06, released 2013-10-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-12-03, with a file datestamp of 2014-11-28.
Experiment type: XRAY
Resolution: 1.45 Å
R-factor: 0.193
AEROSPACI score: 0.56 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein kinase PLK1
    Species: Homo sapiens [TaxId:9606]
    Gene: PLK1, PLK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4mlua3, d4mlua4
  • Chain 'B':
    Compound: Phosphothreonine ester-containing peptide
    Database cross-references and differences (RAF-indexed):
    • PDB 4MLU
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4mluA (A:)
gahmdchlsdmlqqlhsvnaskpserglvrqeeaedpacipifwvskwvdysdkyglgyq
lcdnsvgvlfndstrlilyndgdslqyierdgtesyltvsshpnslmkkitllkyfrnym
sehllkaganitpregdelarlpylrtwfrtrsaiilhlsngsvqinffqdhtklilcpl
maavtyidekrdfrtyrlslleeygcckelasrlryartmvdkllssrsasnrlkas

    Sequence, based on observed residues (ATOM records): (download) 
    >4mluA (A:)
hlsdmlqqlhsvnaskpserglvrqeeaedpacipifwvskwvdysdkyglgyqlcdnsv
gvlfndstrlilyndgdslqyierdgtesyltvsshpnslmkkitllkyfrnymsehllk
aganitprrlpylrtwfrtrsaiilhlsngsvqinffqdhtklilcplmaavtyidekrd
frtyrlslleeygcckelasrlryartmvdkllssr

  • Chain 'B':
    No sequence available.