PDB entry 4meq

View 4meq on RCSB PDB site
Description: Crystal Structure of the first bromodomain of human BRD4 in complex with a 5-methyl-triazolopyrimidine ligand
Class: TRANSCRIPTION/TRANSCRIPTION inhibitor
Keywords: BRD4, CAP, HUNK1, MCAP, Mitotic chromosome associated protein, BRD, Small molecule inhibitor, Structural Genomics COnsortium, SGC, TRANSCRIPTION-TRANSCRIPTION inhibitor complex
Deposited on 2013-08-27, released 2013-09-25
The last revision prior to the SCOPe 2.07 freeze date was dated 2014-02-19, with a file datestamp of 2014-02-14.
Experiment type: XRAY
Resolution: 1.77 Å
R-factor: 0.166
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bromodomain-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD4, HUNK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60885 (2-126)
      • expression tag (0-1)
    Domains in SCOPe 2.07: d4meqa1, d4meqa2
  • Heterogens: EDO, 25O, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4meqA (A:)
    smnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykii
    ktpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqki
    nelptee