PDB entry 4mep

View 4mep on RCSB PDB site
Description: Crystal Structure of the first bromodomain of human BRD4 in complex with a 3-chloro-pyridone ligand
Class: TRANSCRIPTION/TRANSCRIPTION inhibitor
Keywords: BRD4, CAP, HUNK1, MCAP, Mitotic chromosome associated protein, BRD, Small molecule inhibitor, Structural Genomics COnsortium, SGC, TRANSCRIPTION-TRANSCRIPTION inhibitor complex
Deposited on 2013-08-27, released 2013-09-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-02-19, with a file datestamp of 2014-02-14.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: 0.187
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Bromodomain-containing protein 4
  Species: Homo sapiens [TaxId:9606]
  Gene: BRD4, HUNK1
  Database cross-references and differences (RAF-indexed):
  • Uniprot O60885 (2-126)
    • expression tag (0-1)
  Domains in SCOPe 2.08: d4mepa1, d4mepa2
• Heterogens: 24Y, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >4mepA (A:)
  smnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykii
  ktpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqki
  nelptee