PDB entry 4mdn
View 4mdn on RCSB PDB site
Description: Structure of a novel submicromolar MDM2 inhibitor
Class: ligase/ligase inhibitor
Keywords: MDM2, p53, cancer, small molecule, LIGASE-LIGASE INHIBITOR complex
Deposited on
2013-08-23, released
2013-11-13
The last revision prior to the SCOPe 2.08 freeze date was dated
2013-12-25, with a file datestamp of
2013-12-20.
Experiment type: XRAY
Resolution: 1.91 Å
R-factor: 0.181
AEROSPACI score: 0.41
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: E3 ubiquitin-protein ligase Mdm2
Species: Homo sapiens [TaxId:9606]
Gene: MDM2
Database cross-references and differences (RAF-indexed):
- Uniprot Q00987 (1-93)
- initiating methionine (0)
Domains in SCOPe 2.08: d4mdna1, d4mdna2 - Heterogens: Y30, SO4, HOH