PDB entry 4mdk

View 4mdk on RCSB PDB site
Description: Cdc34-ubiquitin-CC0651 complex
Class: ligase/ligase inhibitor
Keywords: ubiquitin conjugating enzyme domain, E2 ligase inhibitor, LIGASE-LIGASE INHIBITOR complex
Deposited on 2013-08-22, released 2013-12-11
The last revision prior to the SCOPe 2.05 freeze date was dated 2014-02-05, with a file datestamp of 2014-01-31.
Experiment type: XRAY
Resolution: 2.61 Å
R-factor: 0.207
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ubiquitin-conjugating enzyme E2 R1
    Species: Homo sapiens [TaxId:9606]
    Gene: CDC34, UBCH3, UBE2R1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4mdka_
  • Chain 'B':
    Compound: Ubiquitin-conjugating enzyme E2 R1
    Species: Homo sapiens [TaxId:9606]
    Gene: CDC34, UBCH3, UBE2R1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4mdkb_
  • Chain 'C':
    Compound: Ubiquitin-conjugating enzyme E2 R1
    Species: Homo sapiens [TaxId:9606]
    Gene: CDC34, UBCH3, UBE2R1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4mdkc_
  • Chain 'D':
    Compound: Ubiquitin-conjugating enzyme E2 R1
    Species: Homo sapiens [TaxId:9606]
    Gene: CDC34, UBCH3, UBE2R1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4mdkd_
  • Chain 'E':
    Compound: Ubiquitin
    Species: Homo sapiens [TaxId:9606]
    Gene: UBC
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0CG48 (3-End)
      • expression tag (2)
    Domains in SCOPe 2.05: d4mdke_
  • Chain 'F':
    Compound: Ubiquitin
    Species: Homo sapiens [TaxId:9606]
    Gene: UBC
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0CG48 (3-End)
      • expression tag (2)
    Domains in SCOPe 2.05: d4mdkf_
  • Chain 'G':
    Compound: Ubiquitin
    Species: Homo sapiens [TaxId:9606]
    Gene: UBC
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4mdkg_
  • Chain 'H':
    Compound: Ubiquitin
    Species: Homo sapiens [TaxId:9606]
    Gene: UBC
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0CG48 (3-End)
      • expression tag (2)
    Domains in SCOPe 2.05: d4mdkh_
  • Heterogens: U94, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4mdkA (A:)
    gspssqkalllelkglqeepvegfrvtlvdegdlynwevaifgppntyyeggyfkarlkf
    pidypysppafrfltkmwhpniyetgdvcisilhppvddpqsgelpserwnptqnvrtil
    lsvisllnepntfspanvdasvmyrkwkeskgkdreytdiirkqvlgtkvdaerdgvkvp
    

    Sequence, based on observed residues (ATOM records): (download)
    >4mdkA (A:)
    pssqkalllelkglqeepvegfrvtlvdegdlynwevaifgppntyyeggyfkarlkfpi
    dypysppafrfltkmwhpniyetgdvcisilhppserwnptqnvrtillsvisllnepnt
    fspanvdasvmyrkwkeskgkdreytdiirkqvlgtkvdaerdgvkvp
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4mdkB (B:)
    gspssqkalllelkglqeepvegfrvtlvdegdlynwevaifgppntyyeggyfkarlkf
    pidypysppafrfltkmwhpniyetgdvcisilhppvddpqsgelpserwnptqnvrtil
    lsvisllnepntfspanvdasvmyrkwkeskgkdreytdiirkqvlgtkvdaerdgvkvp
    

    Sequence, based on observed residues (ATOM records): (download)
    >4mdkB (B:)
    pssqkalllelkglqeepvegfrvtlvdegdlynwevaifgppntyyeggyfkarlkfpi
    dypysppafrfltkmwhpniyetgdvcisiwnptqnvrtillsvisllnepntfspanvd
    asvmyrkwkeskgkdreytdiirkqvlgtkvdaerdgvkvp
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >4mdkC (C:)
    gspssqkalllelkglqeepvegfrvtlvdegdlynwevaifgppntyyeggyfkarlkf
    pidypysppafrfltkmwhpniyetgdvcisilhppvddpqsgelpserwnptqnvrtil
    lsvisllnepntfspanvdasvmyrkwkeskgkdreytdiirkqvlgtkvdaerdgvkvp
    

    Sequence, based on observed residues (ATOM records): (download)
    >4mdkC (C:)
    pssqkalllelkglqeepvegfrvtlvdegdlynwevaifgppntyyeggyfkarlkfpi
    dypysppafrfltkmwhpniyetgdvcisilhppserwnptqnvrtillsvisllnepnt
    fspanvdasvmyrkwkeskgkdreytdiirkqvlgtkvdaerdgvkvp
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >4mdkD (D:)
    gspssqkalllelkglqeepvegfrvtlvdegdlynwevaifgppntyyeggyfkarlkf
    pidypysppafrfltkmwhpniyetgdvcisilhppvddpqsgelpserwnptqnvrtil
    lsvisllnepntfspanvdasvmyrkwkeskgkdreytdiirkqvlgtkvdaerdgvkvp
    

    Sequence, based on observed residues (ATOM records): (download)
    >4mdkD (D:)
    pssqkalllelkglqeepvegfrvtlvdegdlynwevaifgppntyyeggyfkarlkfpi
    dypysppafrfltkmwhpniyetgdvcnptqnvrtillsvisllnepntfspanvdasvm
    yrkwkeskgkdreytdiirkqvlgtkvdaerdgvkvp
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >4mdkE (E:)
    gamgmqifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagkqledgrtl
    sdyniqkestlhlvlrlrgg
    

    Sequence, based on observed residues (ATOM records): (download)
    >4mdkE (E:)
    mgmqifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagkqledgrtlsd
    yniqkestlhlvlrlr
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >4mdkF (F:)
    gamgmqifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagkqledgrtl
    sdyniqkestlhlvlrlrgg
    

    Sequence, based on observed residues (ATOM records): (download)
    >4mdkF (F:)
    mgmqifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagkqledgrtlsd
    yniqkestlhlvlrlr
    

  • Chain 'G':
    Sequence, based on SEQRES records: (download)
    >4mdkG (G:)
    gamgmqifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagkqledgrtl
    sdyniqkestlhlvlrlrgg
    

    Sequence, based on observed residues (ATOM records): (download)
    >4mdkG (G:)
    qifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagkqledgrtlsdyni
    qkestlhlvlrlr
    

  • Chain 'H':
    Sequence, based on SEQRES records: (download)
    >4mdkH (H:)
    gamgmqifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagkqledgrtl
    sdyniqkestlhlvlrlrgg
    

    Sequence, based on observed residues (ATOM records): (download)
    >4mdkH (H:)
    mgmqifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagkqledgrtlsd
    yniqkestlhlvlr