PDB entry 4md9

View 4md9 on RCSB PDB site
Description: Crystal Structure of symmetric CK2 holoenzyme with mutated alpha subunit (F121E truncated at aa 336)
Deposited on 2013-08-22, released 2013-11-20
The last revision was dated 2014-03-05, with a file datestamp of 2014-02-28.
Experiment type: XRAY
Resolution: 3.5 Å
R-factor: 0.23
AEROSPACI score: 0.11 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Casein kinase II subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK2B, CK2N, G5A
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Casein kinase II subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK2B, CK2N, G5A
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Casein kinase II subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK2B, CK2N, G5A
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Casein kinase II subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK2B, CK2N, G5A
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Casein kinase II subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK2A1, CK2A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P68400
      • engineered mutation (120)
  • Chain 'F':
    Compound: Casein kinase II subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK2A1, CK2A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P68400
      • engineered mutation (120)
  • Chain 'G':
    Compound: Casein kinase II subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK2A1, CK2A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P68400
      • engineered mutation (120)
  • Chain 'H':
    Compound: Casein kinase II subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK2A1, CK2A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P68400
      • engineered mutation (120)
  • Chain 'I':
    Compound: Casein kinase II subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK2B, CK2N, G5A
    Database cross-references and differences (RAF-indexed):
  • Chain 'J':
    Compound: Casein kinase II subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK2B, CK2N, G5A
    Database cross-references and differences (RAF-indexed):
  • Chain 'K':
    Compound: Casein kinase II subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK2A1, CK2A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P68400
      • engineered mutation (120)
  • Chain 'L':
    Compound: Casein kinase II subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK2A1, CK2A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P68400
      • engineered mutation (120)
  • Chain 'M':
    Compound: Casein kinase II subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK2A1, CK2A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P68400
      • engineered mutation (120)
  • Chain 'N':
    Compound: Casein kinase II subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK2B, CK2N, G5A
    Database cross-references and differences (RAF-indexed):
  • Chain 'O':
    Compound: Casein kinase II subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK2B, CK2N, G5A
    Database cross-references and differences (RAF-indexed):
  • Chain 'P':
    Compound: Casein kinase II subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK2A1, CK2A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P68400
      • engineered mutation (120)
  • Heterogens: ZN

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >4md9A (A:)
mssseevswiswfcglrgneffcevdedyiqdkfnltglneqvphyrqaldmildlepde
elednpnqsdlieqaaemlygliharyiltnrgiaqmlekyqqgdfgycprvycenqpml
piglsdipgeamvklycpkcmdvytpkssrhhhtdgayfgtgfphmlfmvhpeyrpkrpa
nqfvprlygfkihpmayqlqlqaasnfkspvktir

    Sequence, based on observed residues (ATOM records):
    >4md9A (A:)
vswiswfcglrgneffcevdedyiqdkfnltglneqvphyrqaldmildlepdeelednp
nqsdlieqaaemlygliharyiltnrgiaqmlekyqqgdfgycprvycenqpmlpiglsd
ipgeamvklycpkcmdvytpkssrhhhtdgayfgtgfphmlfmvhpeyrpkrpanqfvpr
lygfkihpmayqlqlqaasnf

  • Chain 'B':
    Sequence, based on SEQRES records:
    >4md9B (B:)
mssseevswiswfcglrgneffcevdedyiqdkfnltglneqvphyrqaldmildlepde
elednpnqsdlieqaaemlygliharyiltnrgiaqmlekyqqgdfgycprvycenqpml
piglsdipgeamvklycpkcmdvytpkssrhhhtdgayfgtgfphmlfmvhpeyrpkrpa
nqfvprlygfkihpmayqlqlqaasnfkspvktir

    Sequence, based on observed residues (ATOM records):
    >4md9B (B:)
evswiswfcglrgneffcevdedyiqdkfnltglneqvphyrqaldmildleppnqsdli
eqaaemlygliharyiltnrgiaqmlekyqqgdfgycprvycenqpmlpiglsdipgeam
vklycpkcmdvytpkssrhhhtdgayfgtgfphmlfmvhpeyrpkrpanqfvprlygfki
hpmayqlqlqaasnf

  • Chain 'C':
    Sequence, based on SEQRES records:
    >4md9C (C:)
mssseevswiswfcglrgneffcevdedyiqdkfnltglneqvphyrqaldmildlepde
elednpnqsdlieqaaemlygliharyiltnrgiaqmlekyqqgdfgycprvycenqpml
piglsdipgeamvklycpkcmdvytpkssrhhhtdgayfgtgfphmlfmvhpeyrpkrpa
nqfvprlygfkihpmayqlqlqaasnfkspvktir

    Sequence, based on observed residues (ATOM records):
    >4md9C (C:)
evswiswfcglrgneffcevdedyiqdkfnltglneqvphyrqaldmildlepdeepnqs
dlieqaaemlygliharyiltnrgiaqmlekyqqgdfgycprvycenqpmlpiglsdipg
eamvklycpkcmdvytpkssrhhhtdgayfgtgfphmlfmvhpeyrpkrpanqfvprlyg
fkihpmayqlqlqaasnf

  • Chain 'D':
    Sequence, based on SEQRES records:
    >4md9D (D:)
mssseevswiswfcglrgneffcevdedyiqdkfnltglneqvphyrqaldmildlepde
elednpnqsdlieqaaemlygliharyiltnrgiaqmlekyqqgdfgycprvycenqpml
piglsdipgeamvklycpkcmdvytpkssrhhhtdgayfgtgfphmlfmvhpeyrpkrpa
nqfvprlygfkihpmayqlqlqaasnfkspvktir

    Sequence, based on observed residues (ATOM records):
    >4md9D (D:)
evswiswfcglrgneffcevdedyiqdkfnltglneqvphyrqaldmildlepnpnqsdl
ieqaaemlygliharyiltnrgiaqmlekyqqgdfgycprvycenqpmlpiglsdipgea
mvklycpkcmdvytpkssrhhhtdgayfgtgfphmlfmvhpeyrpkrpanqfvprlygfk
ihpmayqlqlqaasnf

  • Chain 'E':
    Sequence, based on SEQRES records:
    >4md9E (E:)
msgpvpsrarvytdvnthrpreywdyeshvvewgnqddyqlvrklgrgkysevfeainit
nnekvvvkilkpvkkkkikreikilenlrggpniitladivkdpvsrtpalvfehvnntd
ekqlyqtltdydirfymyeilkaldychsmgimhrdvkphnvmidhehrklrlidwglae
fyhpgqeynvrvasryfkgpellvdyqmydysldmwslgcmlasmifrkepffhghdnyd
qlvriakvlgtedlydyidkynieldprfndilgrhsrkrwerfvhsenqhlvspealdf
ldkllrydhqsrltareamehpyfytvvkdqarmgs

    Sequence, based on observed residues (ATOM records):
    >4md9E (E:)
sgpvpsrarvytdvnthrpreywdyeshvvewgnqddyqlvrklgrgkysevfeainitn
nekvvvkilkpvkkkkikreikilenlrggpniitladivkdpvsrtpalvfehvnntde
kqlyqtltdydirfymyeilkaldychsmgimhrdvkphnvmidhehrklrlidwglaef
yhpgqeynvrvasryfkgpellvdyqmydysldmwslgcmlasmifrkepffhghdnydq
lvriakvlgtedlydyidkynieldprfndilgrhsrkrwerfvhsenqhlvspealdfl
dkllrydhqsrltareamehpyfytvvkd

  • Chain 'F':
    Sequence, based on SEQRES records:
    >4md9F (F:)
msgpvpsrarvytdvnthrpreywdyeshvvewgnqddyqlvrklgrgkysevfeainit
nnekvvvkilkpvkkkkikreikilenlrggpniitladivkdpvsrtpalvfehvnntd
ekqlyqtltdydirfymyeilkaldychsmgimhrdvkphnvmidhehrklrlidwglae
fyhpgqeynvrvasryfkgpellvdyqmydysldmwslgcmlasmifrkepffhghdnyd
qlvriakvlgtedlydyidkynieldprfndilgrhsrkrwerfvhsenqhlvspealdf
ldkllrydhqsrltareamehpyfytvvkdqarmgs

    Sequence, based on observed residues (ATOM records):
    >4md9F (F:)
pvpsrarvytdvnthrpreywdyeshvvewgnqddyqlvrklgrgkysevfeainitnne
kvvvkilkpvkkkkikreikilenlrggpniitladivkdpvsrtpalvfehvnntdekq
lyqtltdydirfymyeilkaldychsmgimhrdvkphnvmidhehrklrlidwglaefyh
pgqeynvrvasryfkgpellvdyqmydysldmwslgcmlasmifrkepffhghdnydqlv
riakvlgtedlydyidkynieldprfndilgrhsrkrwerfvhsenqhlvspealdfldk
llrydhqsrltareamehpyfytvvkd

  • Chain 'G':
    Sequence, based on SEQRES records:
    >4md9G (G:)
msgpvpsrarvytdvnthrpreywdyeshvvewgnqddyqlvrklgrgkysevfeainit
nnekvvvkilkpvkkkkikreikilenlrggpniitladivkdpvsrtpalvfehvnntd
ekqlyqtltdydirfymyeilkaldychsmgimhrdvkphnvmidhehrklrlidwglae
fyhpgqeynvrvasryfkgpellvdyqmydysldmwslgcmlasmifrkepffhghdnyd
qlvriakvlgtedlydyidkynieldprfndilgrhsrkrwerfvhsenqhlvspealdf
ldkllrydhqsrltareamehpyfytvvkdqarmgs

    Sequence, based on observed residues (ATOM records):
    >4md9G (G:)
sgpvpsrarvytdvnthrpreywdyeshvvewgnqddyqlvrklgrgkysevfeainitn
nekvvvkilkpvkkkkikreikilenlrggpniitladivkdpvsrtpalvfehvnntde
kqlyqtltdydirfymyeilkaldychsmgimhrdvkphnvmidhehrklrlidwglaef
yhpgqeynvrvasryfkgpellvdyqmydysldmwslgcmlasmifrkepffhghdnydq
lvriakvlgtedlydyidkynieldprfndilgrhsrkrwerfvhsenqhlvspealdfl
dkllrydhqsrltareamehpyfytvvkd

  • Chain 'H':
    Sequence, based on SEQRES records:
    >4md9H (H:)
msgpvpsrarvytdvnthrpreywdyeshvvewgnqddyqlvrklgrgkysevfeainit
nnekvvvkilkpvkkkkikreikilenlrggpniitladivkdpvsrtpalvfehvnntd
ekqlyqtltdydirfymyeilkaldychsmgimhrdvkphnvmidhehrklrlidwglae
fyhpgqeynvrvasryfkgpellvdyqmydysldmwslgcmlasmifrkepffhghdnyd
qlvriakvlgtedlydyidkynieldprfndilgrhsrkrwerfvhsenqhlvspealdf
ldkllrydhqsrltareamehpyfytvvkdqarmgs

    Sequence, based on observed residues (ATOM records):
    >4md9H (H:)
gpvpsrarvytdvnthrpreywdyeshvvewgnqddyqlvrklgrgkysevfeainitnn
ekvvvkilkpvkkkkikreikilenlrggpniitladivkdpvsrtpalvfehvnntdek
qlyqtltdydirfymyeilkaldychsmgimhrdvkphnvmidhehrklrlidwglaefy
hpgqeynvrvasryfkgpellvdyqmydysldmwslgcmlasmifrkepffhghdnydql
vriakvlgtedlydyidkynieldprfndilgrhsrkrwerfvhsenqhlvspealdfld
kllrydhqsrltareamehpyfytvvkd

  • Chain 'I':
    Sequence, based on SEQRES records:
    >4md9I (I:)
mssseevswiswfcglrgneffcevdedyiqdkfnltglneqvphyrqaldmildlepde
elednpnqsdlieqaaemlygliharyiltnrgiaqmlekyqqgdfgycprvycenqpml
piglsdipgeamvklycpkcmdvytpkssrhhhtdgayfgtgfphmlfmvhpeyrpkrpa
nqfvprlygfkihpmayqlqlqaasnfkspvktir

    Sequence, based on observed residues (ATOM records):
    >4md9I (I:)
vswiswfcglrgneffcevdedyiqdkfnltglneqvphyrqaldmildlepdepnqsdl
ieqaaemlygliharyiltnrgiaqmlekyqqgdfgycprvycenqpmlpiglsdipgea
mvklycpkcmdvytpkssrhhhtdgayfgtgfphmlfmvhpeyrpkrpanqfvprlygfk
ihpmayqlqlqaasnf

  • Chain 'J':
    Sequence, based on SEQRES records:
    >4md9J (J:)
mssseevswiswfcglrgneffcevdedyiqdkfnltglneqvphyrqaldmildlepde
elednpnqsdlieqaaemlygliharyiltnrgiaqmlekyqqgdfgycprvycenqpml
piglsdipgeamvklycpkcmdvytpkssrhhhtdgayfgtgfphmlfmvhpeyrpkrpa
nqfvprlygfkihpmayqlqlqaasnfkspvktir

    Sequence, based on observed residues (ATOM records):
    >4md9J (J:)
vswiswfcglrgneffcevdedyiqdkfnltglneqvphyrqaldmildleppnqsdlie
qaaemlygliharyiltnrgiaqmlekyqqgdfgycprvycenqpmlpiglsdipgeamv
klycpkcmdvytpkssrhhhtdgayfgtgfphmlfmvhpeyrpkrpanqfvprlygfkih
pmayqlqlqaasnf

  • Chain 'K':
    Sequence, based on SEQRES records:
    >4md9K (K:)
msgpvpsrarvytdvnthrpreywdyeshvvewgnqddyqlvrklgrgkysevfeainit
nnekvvvkilkpvkkkkikreikilenlrggpniitladivkdpvsrtpalvfehvnntd
ekqlyqtltdydirfymyeilkaldychsmgimhrdvkphnvmidhehrklrlidwglae
fyhpgqeynvrvasryfkgpellvdyqmydysldmwslgcmlasmifrkepffhghdnyd
qlvriakvlgtedlydyidkynieldprfndilgrhsrkrwerfvhsenqhlvspealdf
ldkllrydhqsrltareamehpyfytvvkdqarmgs

    Sequence, based on observed residues (ATOM records):
    >4md9K (K:)
gpvpsrarvytdvnthrpreywdyeshvvewgnqddyqlvrklgrgkysevfeainitnn
ekvvvkilkpvkkkkikreikilenlrggpniitladivkdpvsrtpalvfehvnntdek
qlyqtltdydirfymyeilkaldychsmgimhrdvkphnvmidhehrklrlidwglaefy
hpgqeynvrvasryfkgpellvdyqmydysldmwslgcmlasmifrkepffhghdnydql
vriakvlgtedlydyidkynieldprfndilgrhsrkrwerfvhsenqhlvspealdfld
kllrydhqsrltareamehpyfytvvkd

  • Chain 'L':
    Sequence, based on SEQRES records:
    >4md9L (L:)
msgpvpsrarvytdvnthrpreywdyeshvvewgnqddyqlvrklgrgkysevfeainit
nnekvvvkilkpvkkkkikreikilenlrggpniitladivkdpvsrtpalvfehvnntd
ekqlyqtltdydirfymyeilkaldychsmgimhrdvkphnvmidhehrklrlidwglae
fyhpgqeynvrvasryfkgpellvdyqmydysldmwslgcmlasmifrkepffhghdnyd
qlvriakvlgtedlydyidkynieldprfndilgrhsrkrwerfvhsenqhlvspealdf
ldkllrydhqsrltareamehpyfytvvkdqarmgs

    Sequence, based on observed residues (ATOM records):
    >4md9L (L:)
gpvpsrarvytdvnthrpreywdyeshvvewgnqddyqlvrklgrgkysevfeainitnn
ekvvvkilkpvkkkkikreikilenlrggpniitladivkdpvsrtpalvfehvnntdek
qlyqtltdydirfymyeilkaldychsmgimhrdvkphnvmidhehrklrlidwglaefy
hpgqeynvrvasryfkgpellvdyqmydysldmwslgcmlasmifrkepffhghdnydql
vriakvlgtedlydyidkynieldprfndilgrhsrkrwerfvhsenqhlvspealdfld
kllrydhqsrltareamehpyfytvvkd

  • Chain 'M':
    Sequence, based on SEQRES records:
    >4md9M (M:)
msgpvpsrarvytdvnthrpreywdyeshvvewgnqddyqlvrklgrgkysevfeainit
nnekvvvkilkpvkkkkikreikilenlrggpniitladivkdpvsrtpalvfehvnntd
ekqlyqtltdydirfymyeilkaldychsmgimhrdvkphnvmidhehrklrlidwglae
fyhpgqeynvrvasryfkgpellvdyqmydysldmwslgcmlasmifrkepffhghdnyd
qlvriakvlgtedlydyidkynieldprfndilgrhsrkrwerfvhsenqhlvspealdf
ldkllrydhqsrltareamehpyfytvvkdqarmgs

    Sequence, based on observed residues (ATOM records):
    >4md9M (M:)
sgpvpsrarvytdvnthrpreywdyeshvvewgnqddyqlvrklgrgkysevfeainitn
nekvvvkilkpvkkkkikreikilenlrggpniitladivkdpvsrtpalvfehvnntde
kqlyqtltdydirfymyeilkaldychsmgimhrdvkphnvmidhehrklrlidwglaef
yhpgqeynvrvasryfkgpellvdyqmydysldmwslgcmlasmifrkepffhghdnydq
lvriakvlgtedlydyidkynieldprfndilgrhsrkrwerfvhsenqhlvspealdfl
dkllrydhqsrltareamehpyfytvvkdqa

  • Chain 'N':
    Sequence, based on SEQRES records:
    >4md9N (N:)
mssseevswiswfcglrgneffcevdedyiqdkfnltglneqvphyrqaldmildlepde
elednpnqsdlieqaaemlygliharyiltnrgiaqmlekyqqgdfgycprvycenqpml
piglsdipgeamvklycpkcmdvytpkssrhhhtdgayfgtgfphmlfmvhpeyrpkrpa
nqfvprlygfkihpmayqlqlqaasnfkspvktir

    Sequence, based on observed residues (ATOM records):
    >4md9N (N:)
vswiswfcglrgneffcevdedyiqdkfnltglneqvphyrqaldmildlepdeepnqsd
lieqaaemlygliharyiltnrgiaqmlekyqqgdfgycprvycenqpmlpiglsdipge
amvklycpkcmdvytpkssrhhhtdgayfgtgfphmlfmvhpeyrpkrpanqfvprlygf
kihpmayqlqlqaasnf

  • Chain 'O':
    Sequence, based on SEQRES records:
    >4md9O (O:)
mssseevswiswfcglrgneffcevdedyiqdkfnltglneqvphyrqaldmildlepde
elednpnqsdlieqaaemlygliharyiltnrgiaqmlekyqqgdfgycprvycenqpml
piglsdipgeamvklycpkcmdvytpkssrhhhtdgayfgtgfphmlfmvhpeyrpkrpa
nqfvprlygfkihpmayqlqlqaasnfkspvktir

    Sequence, based on observed residues (ATOM records):
    >4md9O (O:)
vswiswfcglrgneffcevdedyiqdkfnltglneqvphyrqaldmildlepdeenpnqs
dlieqaaemlygliharyiltnrgiaqmlekyqqgdfgycprvycenqpmlpiglsdipg
eamvklycpkcmdvytpkssrhhhtdgayfgtgfphmlfmvhpeyrpkrpanqfvprlyg
fkihpmayqlqlqaasnf

  • Chain 'P':
    Sequence, based on SEQRES records:
    >4md9P (P:)
msgpvpsrarvytdvnthrpreywdyeshvvewgnqddyqlvrklgrgkysevfeainit
nnekvvvkilkpvkkkkikreikilenlrggpniitladivkdpvsrtpalvfehvnntd
ekqlyqtltdydirfymyeilkaldychsmgimhrdvkphnvmidhehrklrlidwglae
fyhpgqeynvrvasryfkgpellvdyqmydysldmwslgcmlasmifrkepffhghdnyd
qlvriakvlgtedlydyidkynieldprfndilgrhsrkrwerfvhsenqhlvspealdf
ldkllrydhqsrltareamehpyfytvvkdqarmgs

    Sequence, based on observed residues (ATOM records):
    >4md9P (P:)
gpvpsrarvytdvnthrpreywdyeshvvewgnqddyqlvrklgrgkysevfeainitnn
ekvvvkilkpvkkkkikreikilenlrggpniitladivkdpvsrtpalvfehvnntdek
qlyqtltdydirfymyeilkaldychsmgimhrdvkphnvmidhehrklrlidwglaefy
hpgqeynvrvasryfkgpellvdyqmydysldmwslgcmlasmifrkepffhghdnydql
vriakvlgtedlydyidkynieldprfndilgrhsrkrwerfvhsenqhlvspealdfld
kllrydhqsrltareamehpyfytvvkd