PDB entry 4md7

View 4md7 on RCSB PDB site
Description: Crystal Structure of full-length symmetric CK2 holoenzyme
Class: transferase
Keywords: protein serine/threonine kinase, TRANSFERASE
Deposited on 2013-08-22, released 2013-11-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-03-05, with a file datestamp of 2014-02-28.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: 0.235
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Casein kinase II subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK2B, CK2N, G5A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4md7a_
  • Chain 'B':
    Compound: Casein kinase II subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK2B, CK2N, G5A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4md7b_
  • Chain 'C':
    Compound: Casein kinase II subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK2B, CK2N, G5A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4md7c_
  • Chain 'D':
    Compound: Casein kinase II subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK2B, CK2N, G5A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4md7d_
  • Chain 'E':
    Compound: Casein kinase II subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK2A1, CK2A1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4md7e_
  • Chain 'F':
    Compound: Casein kinase II subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK2A1, CK2A1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4md7f_
  • Chain 'G':
    Compound: Casein kinase II subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK2A1, CK2A1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4md7g_
  • Chain 'H':
    Compound: Casein kinase II subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK2A1, CK2A1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4md7h_
  • Heterogens: ZN

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4md7A (A:)
mssseevswiswfcglrgneffcevdedyiqdkfnltglneqvphyrqaldmildlepde
elednpnqsdlieqaaemlygliharyiltnrgiaqmlekyqqgdfgycprvycenqpml
piglsdipgeamvklycpkcmdvytpkssrhhhtdgayfgtgfphmlfmvhpeyrpkrpa
nqfvprlygfkihpmayqlqlqaasnfkspvktir

    Sequence, based on observed residues (ATOM records): (download) 
    >4md7A (A:)
evswiswfcglrgneffcevdedyiqdkfnltglneqvphyrqaldmildlepdednpnq
sdlieqaaemlygliharyiltnrgiaqmlekyqqgdfgycprvycenqpmlpiglsdip
geamvklycpkcmdvytpkssrhhhtdgayfgtgfphmlfmvhpeyrpkrpanqfvprly
gfkihpmayqlqlqaasnf

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4md7B (B:)
mssseevswiswfcglrgneffcevdedyiqdkfnltglneqvphyrqaldmildlepde
elednpnqsdlieqaaemlygliharyiltnrgiaqmlekyqqgdfgycprvycenqpml
piglsdipgeamvklycpkcmdvytpkssrhhhtdgayfgtgfphmlfmvhpeyrpkrpa
nqfvprlygfkihpmayqlqlqaasnfkspvktir

    Sequence, based on observed residues (ATOM records): (download) 
    >4md7B (B:)
vswiswfcglrgneffcevdedyiqdkfnltglneqvphyrqaldmildlepdpnqsdli
eqaaemlygliharyiltnrgiaqmlekyqqgdfgycprvycenqpmlpiglsdipgeam
vklycpkcmdvytpkssrhhhtdgayfgtgfphmlfmvhpeyrpkrpanqfvprlygfki
hpmayqlqlqaasnf

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4md7C (C:)
mssseevswiswfcglrgneffcevdedyiqdkfnltglneqvphyrqaldmildlepde
elednpnqsdlieqaaemlygliharyiltnrgiaqmlekyqqgdfgycprvycenqpml
piglsdipgeamvklycpkcmdvytpkssrhhhtdgayfgtgfphmlfmvhpeyrpkrpa
nqfvprlygfkihpmayqlqlqaasnfkspvktir

    Sequence, based on observed residues (ATOM records): (download) 
    >4md7C (C:)
evswiswfcglrgneffcevdedyiqdkfnltglneqvphyrqaldmildlepdnpnqsd
lieqaaemlygliharyiltnrgiaqmlekyqqgdfgycprvycenqpmlpiglsdipge
amvklycpkcmdvytpkssrhhhtdgayfgtgfphmlfmvhpeyrpkrpanqfvprlygf
kihpmayqlqlqaasnf

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4md7D (D:)
mssseevswiswfcglrgneffcevdedyiqdkfnltglneqvphyrqaldmildlepde
elednpnqsdlieqaaemlygliharyiltnrgiaqmlekyqqgdfgycprvycenqpml
piglsdipgeamvklycpkcmdvytpkssrhhhtdgayfgtgfphmlfmvhpeyrpkrpa
nqfvprlygfkihpmayqlqlqaasnfkspvktir

    Sequence, based on observed residues (ATOM records): (download) 
    >4md7D (D:)
vswiswfcglrgneffcevdedyiqdkfnltglneqvphyrqaldmildlepdpnqsdli
eqaaemlygliharyiltnrgiaqmlekyqqgdfgycprvycenqpmlpiglsdipgeam
vklycpkcmdvytpkssrhhhtdgayfgtgfphmlfmvhpeyrpkrpanqfvprlygfki
hpmayqlqlqaasnf

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4md7E (E:)
msgpvpsrarvytdvnthrpreywdyeshvvewgnqddyqlvrklgrgkysevfeainit
nnekvvvkilkpvkkkkikreikilenlrggpniitladivkdpvsrtpalvfehvnntd
fkqlyqtltdydirfymyeilkaldychsmgimhrdvkphnvmidhehrklrlidwglae
fyhpgqeynvrvasryfkgpellvdyqmydysldmwslgcmlasmifrkepffhghdnyd
qlvriakvlgtedlydyidkynieldprfndilgrhsrkrwerfvhsenqhlvspealdf
ldkllrydhqsrltareamehpyfytvvkdqarmgsssmpggsepvssanmmsgissvpe
peplgplagepviaaanplgmpvpaaagaqq

    Sequence, based on observed residues (ATOM records): (download) 
    >4md7E (E:)
sgpvpsrarvytdvnthrpreywdyeshvvewgnqddyqlvrklgrgkysevfeainitn
nekvvvkilkpvkkkkikreikilenlrggpniitladivkdpvsrtpalvfehvnntdf
kqlyqtltdydirfymyeilkaldychsmgimhrdvkphnvmidhehrklrlidwglaef
yhpgqeynvrvasryfkgpellvdyqmydysldmwslgcmlasmifrkepffhghdnydq
lvriakvlgtedlydyidkynieldprfndilgrhsrkrwerfvhsenqhlvspealdfl
dkllrydhqsrltareamehpyfytvvkdqar

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >4md7F (F:)
msgpvpsrarvytdvnthrpreywdyeshvvewgnqddyqlvrklgrgkysevfeainit
nnekvvvkilkpvkkkkikreikilenlrggpniitladivkdpvsrtpalvfehvnntd
fkqlyqtltdydirfymyeilkaldychsmgimhrdvkphnvmidhehrklrlidwglae
fyhpgqeynvrvasryfkgpellvdyqmydysldmwslgcmlasmifrkepffhghdnyd
qlvriakvlgtedlydyidkynieldprfndilgrhsrkrwerfvhsenqhlvspealdf
ldkllrydhqsrltareamehpyfytvvkdqarmgsssmpggsepvssanmmsgissvpe
peplgplagepviaaanplgmpvpaaagaqq

    Sequence, based on observed residues (ATOM records): (download) 
    >4md7F (F:)
sgpvpsrarvytdvnthrpreywdyeshvvewgnqddyqlvrklgrgkysevfeainitn
nekvvvkilkpvkkkkikreikilenlrggpniitladivkdpvsrtpalvfehvnntdf
kqlyqtltdydirfymyeilkaldychsmgimhrdvkphnvmidhehrklrlidwglaef
yhpgqeynvrvasryfkgpellvdyqmydysldmwslgcmlasmifrkepffhghdnydq
lvriakvlgtedlydyidkynieldprfndilgrhsrkrwerfvhsenqhlvspealdfl
dkllrydhqsrltareamehpyfytvvkdqar

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >4md7G (G:)
msgpvpsrarvytdvnthrpreywdyeshvvewgnqddyqlvrklgrgkysevfeainit
nnekvvvkilkpvkkkkikreikilenlrggpniitladivkdpvsrtpalvfehvnntd
fkqlyqtltdydirfymyeilkaldychsmgimhrdvkphnvmidhehrklrlidwglae
fyhpgqeynvrvasryfkgpellvdyqmydysldmwslgcmlasmifrkepffhghdnyd
qlvriakvlgtedlydyidkynieldprfndilgrhsrkrwerfvhsenqhlvspealdf
ldkllrydhqsrltareamehpyfytvvkdqarmgsssmpggsepvssanmmsgissvpe
peplgplagepviaaanplgmpvpaaagaqq

    Sequence, based on observed residues (ATOM records): (download) 
    >4md7G (G:)
sgpvpsrarvytdvnthrpreywdyeshvvewgnqddyqlvrklgrgkysevfeainitn
nekvvvkilkpvkkkkikreikilenlrggpniitladivkdpvsrtpalvfehvnntdf
kqlyqtltdydirfymyeilkaldychsmgimhrdvkphnvmidhehrklrlidwglaef
yhpgqeynvrvasryfkgpellvdyqmydysldmwslgcmlasmifrkepffhghdnydq
lvriakvlgtedlydyidkynieldprfndilgrhsrkrwerfvhsenqhlvspealdfl
dkllrydhqsrltareamehpyfytvvkdqar

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >4md7H (H:)
msgpvpsrarvytdvnthrpreywdyeshvvewgnqddyqlvrklgrgkysevfeainit
nnekvvvkilkpvkkkkikreikilenlrggpniitladivkdpvsrtpalvfehvnntd
fkqlyqtltdydirfymyeilkaldychsmgimhrdvkphnvmidhehrklrlidwglae
fyhpgqeynvrvasryfkgpellvdyqmydysldmwslgcmlasmifrkepffhghdnyd
qlvriakvlgtedlydyidkynieldprfndilgrhsrkrwerfvhsenqhlvspealdf
ldkllrydhqsrltareamehpyfytvvkdqarmgsssmpggsepvssanmmsgissvpe
peplgplagepviaaanplgmpvpaaagaqq

    Sequence, based on observed residues (ATOM records): (download) 
    >4md7H (H:)
pvpsrarvytdvnthrpreywdyeshvvewgnqddyqlvrklgrgkysevfeainitnne
kvvvkilkpvkkkkikreikilenlrggpniitladivkdpvsrtpalvfehvnntdfkq
lyqtltdydirfymyeilkaldychsmgimhrdvkphnvmidhehrklrlidwglaefyh
pgqeynvrvasryfkgpellvdyqmydysldmwslgcmlasmifrkepffhghdnydqlv
riakvlgtedlydyidkynieldprfndilgrhsrkrwerfvhsenqhlvspealdfldk
llrydhqsrltareamehpyfytvvkdqar