PDB entry 4mcv

View 4mcv on RCSB PDB site
Description: Star 12 bound to analog-sensitive Src kinase
Class: transferase/transferase inhibitor
Keywords: Kinase Domain, Tyrosine Kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2013-08-21, released 2013-11-20
The last revision prior to the SCOPe 2.04 freeze date was dated 2013-12-18, with a file datestamp of 2013-12-13.
Experiment type: XRAY
Resolution: 2.73 Å
R-factor: 0.243
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Proto-oncogene tyrosine-protein kinase Src
    Species: Gallus gallus [TaxId:9031]
    Gene: SRC
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00523 (0-277)
      • engineered mutation (82)
    Domains in SCOPe 2.04: d4mcva_
  • Chain 'B':
    Compound: Proto-oncogene tyrosine-protein kinase Src
    Species: Gallus gallus [TaxId:9031]
    Gene: SRC
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00523 (Start-277)
      • engineered mutation (82)
    Domains in SCOPe 2.04: d4mcvb_
  • Heterogens: 29K

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4mcvA (A:)
akdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaflqeaqvmk
klrheklvqlyavvseepiyivgeymskgslldflkgemgkylrlpqlvdmaaqiasgma
yvermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpikwtapeaal
ygrftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppecpeslhdlm
cqcwrkdpeerptfeylqafledyftstepqyqpgenl

    Sequence, based on observed residues (ATOM records): (download) 
    >4mcvA (A:)
akdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaflqeaqvmk
klrheklvqlyavvseepiyivgeymskgslldflkgemgkylrlpqlvdmaaqiasgma
yvermnyvhrdlraanilvgenlvckvadfglarliefpikwtapeaalygrftiksdvw
sfgilltelttkgrvpypgmvnrevldqvergyrmpcppecpeslhdlmcqcwrkdpeer
ptfeylqafledyftstepqyqpgenl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4mcvB (B:)
akdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaflqeaqvmk
klrheklvqlyavvseepiyivgeymskgslldflkgemgkylrlpqlvdmaaqiasgma
yvermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpikwtapeaal
ygrftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppecpeslhdlm
cqcwrkdpeerptfeylqafledyftstepqyqpgenl

    Sequence, based on observed residues (ATOM records): (download) 
    >4mcvB (B:)
kdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkptmspeaflqeaqvmkkl
rheklvqlyavvseepiyivgeymskgslldflkgemgkylrlpqlvdmaaqiasgmayv
ermnyvhrdlraanilvgenlvckvadfglarlikfpikwtapeaalygrftiksdvwsf
gilltelttkgrvpypgmvnrevldqvergyrmpcppecpeslhdlmcqcwrkdpeerpt
feylqafledyftstepqyqpgenl