PDB entry 4mcs

View 4mcs on RCSB PDB site
Description: a high resolution structure of human glutamate carboxypeptidase ii (gcpii) his475tyr variant in complex with glutamic acid
Deposited on 2013-08-21, released 2014-06-18
The last revision was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 1.83 Å
R-factor: N/A
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: glutamate carboxypeptidase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: FOLH1, FOLH, NAALAD1, PSM, PSMA, GIG27
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q04609 (Start-756)
      • engineered mutation (481)
  • Heterogens: NAG, ZN, CA, CL, GLU, ASP, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >4mcsA (A:)
mklcillavvafvglslgrsglndifeaqkiewhegsgsgsenlyfqgrskssneatnit
pkhnmkafldelkaenikkflynftqiphlagteqnfqlakqiqsqwkefgldsvelahy
dvllsypnkthpnyisiinedgneifntslfeppppgyenvsdivppfsafspqgmpegd
lvyvnyartedffklerdmkincsgkiviarygkvfrgnkvknaqlagakgvilysdpad
yfapgvksypdgwnlpgggvqrgnilnlngagdpltpgypaneyayrrgiaeavglpsip
vhpigyydaqkllekmggsappdsswrgslkvpynvgpgftgnfstqkvkmhihstnevt
riynvigtlrgavepdryvilgghrdswvfggidpqsgaavvheivrsfgtlkkegwrpr
rtilfaswdaeefgllgstewaeensrllqergvayinadssiegnytlrvdctplmysl
vynltkelkspdegfegkslyeswtkkspspefsgmprisklgsgndfevffqrlgiasg
rarytknwetnkfsgyplyhsvyetyelvekfydpmfkyhltvaqvrggmvfelansivl
pfdcrdyavvlrkyadkiysismkhpqemktysvsfdslfsavknfteiaskfserlqdf
dksnpivlrmmndqlmflerafidplglpdrpfyrhviyapsshnkyagesfpgiydalf
dieskvdpskawgevkrqiyvaaftvqaaaetlseva

    Sequence, based on observed residues (ATOM records):
    >4mcsA (A:)
khnmkafldelkaenikkflynftqiphlagteqnfqlakqiqsqwkefgldsvelahyd
vllsypnkthpnyisiinedgneifntslfeppppgyenvsdivppfsafspqgmpegdl
vyvnyartedffklerdmkincsgkiviarygkvfrgnkvknaqlagakgvilysdpady
fapgvksypdgwnlpgggvqrgnilnlngagdpltpgypaneyayrrgiaeavglpsipv
hpigyydaqkllekmggsappdsswrgslkvpynvgpgftgnfstqkvkmhihstnevtr
iynvigtlrgavepdryvilgghrdswvfggidpqsgaavvheivrsfgtlkkegwrprr
tilfaswdaeefgllgstewaeensrllqergvayinadssiegnytlrvdctplmyslv
ynltkelkspdegfegkslyeswtkkspspefsgmprisklgsgndfevffqrlgiasgr
arytknnkfsgyplyhsvyetyelvekfydpmfkyhltvaqvrggmvfelansivlpfdc
rdyavvlrkyadkiysismkhpqemktysvsfdslfsavknfteiaskfserlqdfsnpi
vlrmmndqlmflerafidplglpdrpfyrhviyapsshnkyagesfpgiydalfdieskv
dpskawgevkrqiyvaaftvqaaaetlseva