PDB entry 4mbj

View 4mbj on RCSB PDB site
Description: Human B-Raf Kinase Domain in Complex with an Imidazopyridine-based Inhibitor
Deposited on 2013-08-19, released 2013-10-02
The last revision was dated 2013-11-06, with a file datestamp of 2013-11-01.
Experiment type: XRAY
Resolution: 3.6 Å
R-factor: 0.276
AEROSPACI score: 0.04 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein kinase B-raf
    Species: Homo sapiens [TaxId:9606]
    Gene: BRAF, BRAF1, RAFB1
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Serine/threonine-protein kinase B-raf
    Species: Homo sapiens [TaxId:9606]
    Gene: BRAF, BRAF1, RAFB1
    Database cross-references and differences (RAF-indexed):
  • Heterogens: DFS

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >4mbjA (A:)
mdrgshhhhhhgsedrnrmktlgrrdssddweipdgqitvgqrigsgsfgtvykgkwhgd
vavkmlnvtaptpqqlqafknevgvlrktrhvnillfmgystkpqlaivtqwcegsslyh
hlhiietkfemiklidiarqtaqgmdylhaksiihrdlksnniflhedltvkigdfglat
vksrwsgshqfeqlsgsilwmapevirmqdknpysfqsdvyafgivlyelmtgqlpysni
nnrdqiifmvgrgylspdlskvrsncpkamkrlmaeclkkkrderplfpqilasiellar
slpk

    Sequence, based on observed residues (ATOM records):
    >4mbjA (A:)
ddweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrk
trhvnillfmgystkpqlaivtqwcegsslyhhlhiietkfemiklidiarqtaqgmdyl
haksiihrdlksnniflhedltvkigdfglatvksrwslsgsilwmapevirmqdknpys
fqsdvyafgivlyelmtgqlpysninnrdqiifmvgrgylspdlskvrsncpkamkrlma
eclkkkrderplfpqilasiellarslpk

  • Chain 'B':
    Sequence, based on SEQRES records:
    >4mbjB (B:)
mdrgshhhhhhgsedrnrmktlgrrdssddweipdgqitvgqrigsgsfgtvykgkwhgd
vavkmlnvtaptpqqlqafknevgvlrktrhvnillfmgystkpqlaivtqwcegsslyh
hlhiietkfemiklidiarqtaqgmdylhaksiihrdlksnniflhedltvkigdfglat
vksrwsgshqfeqlsgsilwmapevirmqdknpysfqsdvyafgivlyelmtgqlpysni
nnrdqiifmvgrgylspdlskvrsncpkamkrlmaeclkkkrderplfpqilasiellar
slpk

    Sequence, based on observed residues (ATOM records):
    >4mbjB (B:)
ddweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrk
trhvnillfmgystkpqlaivtqwcegsslyhhlhiietkfemiklidiarqtaqgmdyl
haksiihrdlksnniflhedltvkigdfglatvksrwsgshqfeqlsgsilwmapevirm
qdknpysfqsdvyafgivlyelmtgqlpysninnrdqiifmvgrgylspdlskvrsncpk
amkrlmaeclkkkrderplfpqilasiellarslpk