PDB entry 4m6p

View 4m6p on RCSB PDB site
Description: Identification of Amides Derived From 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)
Class: transferase/transferase inhibitor
Keywords: Transferase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2013-08-10, released 2013-09-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-01-24, with a file datestamp of 2018-01-19.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: N/A
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Nicotinamide phosphoribosyltransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: NAMPT, PBEF, PBEF1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4m6pa1, d4m6pa2
  • Chain 'B':
    Compound: Nicotinamide phosphoribosyltransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: NAMPT, PBEF, PBEF1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4m6pb1, d4m6pb2
  • Heterogens: 20R, PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4m6pA (A:)
mnpaaeaefnillatdsykvthykqyppntskvysyfecrekktensklrkvkyeetvfy
glqyilnkylkgkvvtkekiqeakdvykehfqddvfnekgwnyilekydghlpieikavp
egfviprgnvlftventdpecywltnwietilvqswypitvatnsreqkkilakyllets
gnldgleyklhdfgyrgvssqetagigasahlvnfkgtdtvaglalikkyygtkdpvpgy
svpaaehstitawgkdhekdafehivtqfssvpvsvvsdsydiynacekiwgedlrhliv
srstqapliirpdsgnpldtvlkvleilgkkfpvtenskgykllppylrviqgdgvdint
lqeivegmkqkmwsieniafgsgggllqkltrdllncsfkcsyvvtnglginvfkdpvad
pnkrskkgrlslhrtpagnfvtleegkgdleeygqdllhtvfkngkvtksysfdeirkna
qlnieleaahhlehhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4m6pA (A:)
efnillatdsykvthykqyppntskvysyfecrekkkyeetvfyglqyilnkylkgkvvt
kekiqeakdvykehfqddvfnekgwnyilekydghlpieikavpegfviprgnvlftven
tdpecywltnwietilvqswypitvatnsreqkkilakylletsgnldgleyklhdfgyr
gvssqetagigasahlvnfkgtdtvaglalikkyygtkdpvpgysvpaaehstitawgkd
hekdafehivtqfssvpvsvvsdsydiynacekiwgedlrhlivsrstqapliirpdsgn
pldtvlkvleilgkkfpvtenskgykllppylrviqgdgvdintlqeivegmkqkmwsie
niafgsgggllqkltrdllncsfkcsyvvtnglginvfkdpvadpnkrskkgrlslhrtp
agnfvtleegkgdleeygqdllhtvfkngkvtksysfdeirknaqlnielea

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4m6pB (B:)
mnpaaeaefnillatdsykvthykqyppntskvysyfecrekktensklrkvkyeetvfy
glqyilnkylkgkvvtkekiqeakdvykehfqddvfnekgwnyilekydghlpieikavp
egfviprgnvlftventdpecywltnwietilvqswypitvatnsreqkkilakyllets
gnldgleyklhdfgyrgvssqetagigasahlvnfkgtdtvaglalikkyygtkdpvpgy
svpaaehstitawgkdhekdafehivtqfssvpvsvvsdsydiynacekiwgedlrhliv
srstqapliirpdsgnpldtvlkvleilgkkfpvtenskgykllppylrviqgdgvdint
lqeivegmkqkmwsieniafgsgggllqkltrdllncsfkcsyvvtnglginvfkdpvad
pnkrskkgrlslhrtpagnfvtleegkgdleeygqdllhtvfkngkvtksysfdeirkna
qlnieleaahhlehhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4m6pB (B:)
efnillatdsykvthykqyppntskvysyfecrevkyeetvfyglqyilnkylkgkvvtk
ekiqeakdvykehfqddvfnekgwnyilekydghlpieikavpegfviprgnvlftvent
dpecywltnwietilvqswypitvatnsreqkkilakylletsgnldgleyklhdfgyrg
vssqetagigasahlvnfkgtdtvaglalikkyygtkdpvpgysvpaaehstitawgkdh
ekdafehivtqfssvpvsvvsdsydiynacekiwgedlrhlivsrstqapliirpdsgnp
ldtvlkvleilgkkfpvtenskgykllppylrviqgdgvdintlqeivegmkqkmwsien
iafgsgggllqkltrdllncsfkcsyvvtnglginvfkdpvadpnkrskkgrlslhrtpa
gnfvtleegkgdleeygqdllhtvfkngkvtksysfdeirknaqlnielea