PDB entry 4m6j

View 4m6j on RCSB PDB site
Description: Crystal structure of human dihydrofolate reductase (DHFR) bound to NADPH
Class: oxidoreductase
Keywords: Rossmann Fold, NADPH binding, folate binding, OXIDOREDUCTASE
Deposited on 2013-08-09, released 2013-09-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-11-20, with a file datestamp of 2013-11-15.
Experiment type: XRAY
Resolution: 1.2 Å
R-factor: 0.164
AEROSPACI score: 0.74 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydrofolate reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: Dhfr
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4m6ja_
  • Heterogens: NDP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4m6jA (A:)
mvgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfs
ipeknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggss
vykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykf
evyeknd

    Sequence, based on observed residues (ATOM records): (download) 
    >4m6jA (A:)
slncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsipe
knrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssvyk
eamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfevy
eknd