PDB entry 4m5n

View 4m5n on RCSB PDB site
Description: The Identification, Analysis and Structure-Based Development of Novel Inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
Class: Transferase/Transferase Inhibitor
Keywords: FOLATE BIOSYNTHESIS, Diphosphotransferases, PTERIN, ATP binding, Inhibitor, Transferase-Transferase Inhibitor complex
Deposited on 2013-08-08, released 2014-04-02
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-06-11, with a file datestamp of 2014-06-06.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.161
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
    Species: Escherichia coli [TaxId:83333]
    Gene: folK, b0142, JW0138
    Database cross-references and differences (RAF-indexed):
    • Uniprot P26281 (3-161)
      • expression tag (2)
    Domains in SCOPe 2.08: d4m5na1, d4m5na2
  • Chain 'B':
    Compound: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
    Species: Escherichia coli [TaxId:83333]
    Gene: folK, b0142, JW0138
    Database cross-references and differences (RAF-indexed):
    • Uniprot P26281 (3-161)
      • expression tag (2)
    Domains in SCOPe 2.08: d4m5nb1, d4m5nb2
  • Heterogens: MG, APC, YH7, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4m5nA (A:)
gshmtvayiaigsnlaspleqvnaalkalgdipeshiltvssfyrtpplgpqdqpdylna
avaletslapeellnhtqrielqqgrvrkaerwgprtldldimlfgnevinterltvphy
dmknrgfmlwplfeiapelvfpdgemlrqilhtrafdklnkw

    Sequence, based on observed residues (ATOM records): (download) 
    >4m5nA (A:)
hmtvayiaigsnlaspleqvnaalkalgdipeshiltvssfyrtpplgpqdqpdylnaav
aletslapeellnhtqrielqqgrvrkaerwgprtldldimlfgnevinterltvphydm
knrgfmlwplfeiapelvfpdgemlrqilhtrafdklnkw

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4m5nB (B:)
gshmtvayiaigsnlaspleqvnaalkalgdipeshiltvssfyrtpplgpqdqpdylna
avaletslapeellnhtqrielqqgrvrkaerwgprtldldimlfgnevinterltvphy
dmknrgfmlwplfeiapelvfpdgemlrqilhtrafdklnkw

    Sequence, based on observed residues (ATOM records): (download) 
    >4m5nB (B:)
hmtvayiaigsnlaspleqvnaalkalgdipeshiltvssfyrtpplgpqdqpdylnaav
aletslapeellnhtqrielqqgrvrkaerwgprtldldimlfgnevinterltvphydm
knrgfmlwplfeiapelvfpdgemlrqilhtrafdklnkw