PDB entry 4m3p

View 4m3p on RCSB PDB site
Description: Betaine-Homocysteine S-Methyltransferase from Homo sapiens complexed with Homocysteine
Class: transferase
Keywords: Alpha and beta proteins (a/b), TIM beta/alpha-barrel, methyltransferase activity, homocysteine S-methyltransferase activity, transferase activity, metal ion binding, betaine-homocysteine S-methyltransferase activity, protein complex binding, betaine, homocysteine, TRANSFERASE
Deposited on 2013-08-06, released 2014-06-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-10-08, with a file datestamp of 2014-10-03.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.182
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Betaine--homocysteine S-methyltransferase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: BHMT
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q93088
      • see remark 999 (238)
    Domains in SCOPe 2.08: d4m3pa_
  • Chain 'B':
    Compound: Betaine--homocysteine S-methyltransferase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: BHMT
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q93088
      • see remark 999 (238)
    Domains in SCOPe 2.08: d4m3pb_
  • Chain 'C':
    Compound: Betaine--homocysteine S-methyltransferase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: BHMT
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q93088
      • see remark 999 (238)
    Domains in SCOPe 2.08: d4m3pc_
  • Chain 'D':
    Compound: Betaine--homocysteine S-methyltransferase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: BHMT
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q93088
      • see remark 999 (238)
    Domains in SCOPe 2.08: d4m3pd_
  • Heterogens: ZN, K, HCS, SRT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4m3pA (A:)
mppvggkkakkgilerlnageivigdggfvfalekrgyvkagpwtpeaavehpeavrqlh
reflragsnvmqtftfyasedklenrgnyvlekisgqevneaacdiarqvadegdalvag
gvsqtpsylscksetevkkvflqqlevfmkknvdfliaeyfehveeavwavetliasgkp
vaatmcigpegdlhgvppgecavrlvkagasiigvnchfdptislktvklmkegleaaql
kahlmsqplayhtpdcnkqgfidlpefpfgleprvatrwdiqkyareaynlgvryiggcc
gfepyhiraiaeelapergflppasekhgswgsgldmhtkpwvrararkeywenlriasg
rpynpsmskpdgwgvtkgtaelmqqkeatteqqlkelfekqkfksq

    Sequence, based on observed residues (ATOM records): (download) 
    >4m3pA (A:)
kkgilerlnageivigdggfvfalekrgyvkagpwtpeaavehpeavrqlhreflragsn
vmqtftfysgqevneaacdiarqvadegdalvaggvsqtpksetevkkvflqqlevfmkk
nvdfliaeyfehveeavwavetliasgkpvaatmcigpegdlhgvppgecavrlvkagas
iigvnchfdptislktvklmkegleaaqlkahlmsqplayhtpdcnkqgfidlpefpfgl
eprvatrwdiqkyareaynlgvryiggccgfepyhiraiaeelapergflppasekhgsw
gsgldmhtkpwvrararkeywenlriasgrpynpsmskpdgwgvtkgtaelmqqkeatte
qqlkelfekq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4m3pB (B:)
mppvggkkakkgilerlnageivigdggfvfalekrgyvkagpwtpeaavehpeavrqlh
reflragsnvmqtftfyasedklenrgnyvlekisgqevneaacdiarqvadegdalvag
gvsqtpsylscksetevkkvflqqlevfmkknvdfliaeyfehveeavwavetliasgkp
vaatmcigpegdlhgvppgecavrlvkagasiigvnchfdptislktvklmkegleaaql
kahlmsqplayhtpdcnkqgfidlpefpfgleprvatrwdiqkyareaynlgvryiggcc
gfepyhiraiaeelapergflppasekhgswgsgldmhtkpwvrararkeywenlriasg
rpynpsmskpdgwgvtkgtaelmqqkeatteqqlkelfekqkfksq

    Sequence, based on observed residues (ATOM records): (download) 
    >4m3pB (B:)
kakkgilerlnageivigdggfvfalekrgyvkagpwtpeaavehpeavrqlhreflrag
snvmqtftfysgqevneaacdiarqvadegdalvaggvsqtpsetevkkvflqqlevfmk
knvdfliaeyfehveeavwavetliasgkpvaatmcigpegdlhgvppgecavrlvkaga
siigvnchfdptislktvklmkegleaaqlkahlmsqplayhtpdcnkqgfidlpefpfg
leprvatrwdiqkyareaynlgvryiggccgfepyhiraiaeelapergflppasekhgs
wgsgldmhtkpwvrararkeywenlriasgrpynpsmskpdgwgvtkgtaelmqqkeatt
eqqlkelfekqkf

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4m3pC (C:)
mppvggkkakkgilerlnageivigdggfvfalekrgyvkagpwtpeaavehpeavrqlh
reflragsnvmqtftfyasedklenrgnyvlekisgqevneaacdiarqvadegdalvag
gvsqtpsylscksetevkkvflqqlevfmkknvdfliaeyfehveeavwavetliasgkp
vaatmcigpegdlhgvppgecavrlvkagasiigvnchfdptislktvklmkegleaaql
kahlmsqplayhtpdcnkqgfidlpefpfgleprvatrwdiqkyareaynlgvryiggcc
gfepyhiraiaeelapergflppasekhgswgsgldmhtkpwvrararkeywenlriasg
rpynpsmskpdgwgvtkgtaelmqqkeatteqqlkelfekqkfksq

    Sequence, based on observed residues (ATOM records): (download) 
    >4m3pC (C:)
kkgilerlnageivigdggfvfalekrgyvkagpwtpeaavehpeavrqlhreflragsn
vmqtftfykisgqevneaacdiarqvadegdalvaggvsqtpsylscksetevkkvflqq
levfmkknvdfliaeyfehveeavwavetliasgkpvaatmcigpegdlhgvppgecavr
lvkagasiigvnchfdptislktvklmkegleaaqlkahlmsqplayhtpdcnkqgfidl
pefpfgleprvatrwdiqkyareaynlgvryiggccgfepyhiraiaeelapergflppa
sekhgswgsgldmhtkpwvrararkeywenlriasgrpynpsmskpdgwkelfek

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4m3pD (D:)
mppvggkkakkgilerlnageivigdggfvfalekrgyvkagpwtpeaavehpeavrqlh
reflragsnvmqtftfyasedklenrgnyvlekisgqevneaacdiarqvadegdalvag
gvsqtpsylscksetevkkvflqqlevfmkknvdfliaeyfehveeavwavetliasgkp
vaatmcigpegdlhgvppgecavrlvkagasiigvnchfdptislktvklmkegleaaql
kahlmsqplayhtpdcnkqgfidlpefpfgleprvatrwdiqkyareaynlgvryiggcc
gfepyhiraiaeelapergflppasekhgswgsgldmhtkpwvrararkeywenlriasg
rpynpsmskpdgwgvtkgtaelmqqkeatteqqlkelfekqkfksq

    Sequence, based on observed residues (ATOM records): (download) 
    >4m3pD (D:)
kkgilerlnageivigdggfvfalekrgyvkagpwtpeaavehpeavrqlhreflragsn
vmqtftfysgqevneaacdiarqvadegdalvaggvsqtpsylscksetevkkvflqqle
vfmkknvdfliaeyfehveeavwavetliasgkpvaatmcigpegdlhgvppgecavrlv
kagasiigvnchfdptislktvklmkegleaaqlkahlmsqplayhtpdcnkqgfidlpe
fpfgleprvatrwdiqkyareaynlgvryiggccgfepyhiraiaeelapergflppase
khgswgsgldmhtkpwvrararkeywenlriasgrpynpsmskpdgwaelmqqkeatteq
qlkelfekqkf