PDB entry 4m3e
View 4m3e on RCSB PDB site
Description: Rapid and efficient design of new inhibitors of Mycobacterium tuberculosis transcriptional repressor EthR using fragment growing, merging and linking approaches
Class: transcription repressor/inhibitor
Keywords: helix-turn-helix DNA binding protein, TETR-family, transcriptional regulatory repressor, inhibitor, TRANSCRIPTION REPRESSOR-INHIBITOR complex
Deposited on
2013-08-06, released
2014-06-25
The last revision prior to the SCOPe 2.08 freeze date was dated
2014-06-25, with a file datestamp of
2014-06-20.
Experiment type: XRAY
Resolution: 2.11 Å
R-factor: 0.255
AEROSPACI score: 0.27
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: HTH-type transcriptional regulator EthR
Species: Mycobacterium tuberculosis [TaxId:83332]
Gene: etaR, ethR, MT3970, Rv3855
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4m3ea1, d4m3ea2 - Heterogens: 2B3, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4m3eA (A:)
mttsaasqaslprgrrtarpsgddrelailataenlledrpladisvddlakgagisrpt
fyfyfpskeavlltlldrvvnqadmalqtlaenpadtdrenmwrtginvffetfgshkav
tragqaaratsvevaelwstfmqkwiaytaavidaerdrgaaprtlpahelatalnlmne
rtlfasfageqpsvpearvldtlvhiwvtsiygenr
Sequence, based on observed residues (ATOM records): (download)
>4m3eA (A:)
gddrelailataenlledrpladisvddlakgagisrptfyfyfpskeavlltlldrvvn
qadmalqtlaenpadtdrenmwrtginvffetfgshkavtragqaaratsvevaelwstf
mqkwiaytaavidaerdrgaaprtlpahelatalnlmnertlfasfageqpsvpearvld
tlvhiwvtsiyge