PDB entry 4m3d

View 4m3d on RCSB PDB site
Description: Rapid and efficient design of new inhibitors of Mycobacterium tuberculosis transcriptional repressor EthR using fragment growing, merging and linking approaches
Class: transcription repressor/inhibitor
Keywords: helix-turn-helix DNA binding protein, TETR-family, transcriptional regulatory repressor, inhibitor, TRANSCRIPTION REPRESSOR-INHIBITOR complex
Deposited on 2013-08-06, released 2014-06-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-06-25, with a file datestamp of 2014-06-20.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.175
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: HTH-type transcriptional regulator EthR
    Species: Mycobacterium tuberculosis [TaxId:83332]
    Gene: etaR, ethR, MT3970, Rv3855
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4m3da1, d4m3da2
  • Heterogens: 2H2, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4m3dA (A:)
mttsaasqaslprgrrtarpsgddrelailataenlledrpladisvddlakgagisrpt
fyfyfpskeavlltlldrvvnqadmalqtlaenpadtdrenmwrtginvffetfgshkav
tragqaaratsvevaelwstfmqkwiaytaavidaerdrgaaprtlpahelatalnlmne
rtlfasfageqpsvpearvldtlvhiwvtsiygenr

    Sequence, based on observed residues (ATOM records): (download) 
    >4m3dA (A:)
ddrelailataenlledrpladisvddlakgagisrptfyfyfpskeavlltlldrvvnq
admalqtlaenpadtdrenmwrtginvffetfgshkavtragqaaratsvevaelwstfm
qkwiaytaavidaerdrgaaprtlpahelatalnlmnertlfasfageqpsvpearvldt
lvhiwvtsiyge