PDB entry 4m1y
View 4m1y on RCSB PDB site
Description: Crystal Structure of small molecule vinylsulfonamide 15 covalently bound to K-Ras G12C
Class: signaling protein/inhibitor
Keywords: GTPase, GDP bound, small molecule inhibitor, covalent binder, SIGNALING PROTEIN-INHIBITOR complex
Deposited on
2013-08-04, released
2013-11-27
The last revision prior to the SCOPe 2.08 freeze date was dated
2017-11-15, with a file datestamp of
2017-11-10.
Experiment type: XRAY
Resolution: 1.49 Å
R-factor: N/A
AEROSPACI score: 0.49
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: K-Ras GTPase
Species: Homo sapiens [TaxId:9606]
Gene: KRAS, KRAS isoform 2B, KRAS2, RASK2
Database cross-references and differences (RAF-indexed):
- Uniprot P01116 (1-End)
- variant (12)
- engineered mutation (51)
- engineered mutation (80)
- engineered mutation (118)
- see remark 999 (151)
- see remark 999 (153)
- see remark 999 (165-168)
Domains in SCOPe 2.08: d4m1ya_ - Chain 'B':
Compound: K-Ras GTPase
Species: Homo sapiens [TaxId:9606]
Gene: KRAS, KRAS isoform 2B, KRAS2, RASK2
Database cross-references and differences (RAF-indexed):
- Uniprot P01116 (1-169)
- variant (12)
- engineered mutation (51)
- engineered mutation (80)
- engineered mutation (118)
- see remark 999 (151)
- see remark 999 (153)
- see remark 999 (165-168)
Domains in SCOPe 2.08: d4m1yb_ - Chain 'C':
Compound: K-Ras GTPase
Species: Homo sapiens [TaxId:9606]
Gene: KRAS, KRAS isoform 2B, KRAS2, RASK2
Database cross-references and differences (RAF-indexed):
- Uniprot P01116 (1-End)
- variant (12)
- engineered mutation (51)
- engineered mutation (80)
- engineered mutation (118)
- see remark 999 (151)
- see remark 999 (153)
- see remark 999 (165-167)
Domains in SCOPe 2.08: d4m1yc_ - Heterogens: GDP, 21S, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4m1yA (A:)
gmteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetslldildta
gqeeysamrdqymrtgegfllvfainntksfedihhyreqikrvkdsedvpmvlvgnksd
lpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhkek
Sequence, based on observed residues (ATOM records): (download)
>4m1yA (A:)
mteyklvvvgacgvgksaltiqliqnhfvdeedsyrkqvvidgetslldildtageeysa
mrdqymrtgegfllvfainntksfedihhyreqikrvkdsedvpmvlvgnksdlpsrtvd
tkqaqdlarsygipfietsaktrqgvddafytlvreirkhke
- Chain 'B':
Sequence, based on SEQRES records: (download)
>4m1yB (B:)
gmteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetslldildta
gqeeysamrdqymrtgegfllvfainntksfedihhyreqikrvkdsedvpmvlvgnksd
lpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhkek
Sequence, based on observed residues (ATOM records): (download)
>4m1yB (B:)
mteyklvvvgacgvgksaltiqliqnhfvdsyrkqvvidgetslldildtagqeeysamr
dqymrtgegfllvfainntksfedihhyreqikrvkdsedvpmvlvgnksdlpsrtvdtk
qaqdlarsygipfietsaktrqgvddafytlvreirkhkek
- Chain 'C':
Sequence, based on SEQRES records: (download)
>4m1yC (C:)
gmteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetslldildta
gqeeysamrdqymrtgegfllvfainntksfedihhyreqikrvkdsedvpmvlvgnksd
lpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhkek
Sequence, based on observed residues (ATOM records): (download)
>4m1yC (C:)
mteyklvvvgacgvgksaltiqliqnhfvsyrkqvvidgetslldildtagrdqymrtge
gfllvfainntksfedihhyreqikrvkdsedvpmvlvgnksdlpsrtvdtkqaqdlars
ygipfietsaktrqgvddafytlvreirkhk