PDB entry 4lys

View 4lys on RCSB PDB site
Description: Crystal Structure of BRD4(1) bound to Colchiceine
Class: protein binding/inhibitor
Keywords: bromodomain, BRD4 inhibitor, epigenetic reader protein, acetylated lysine, histone tail, nucleus, PROTEIN BINDING-INHIBITOR complex
Deposited on 2013-07-31, released 2014-01-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-01-29, with a file datestamp of 2014-01-24.
Experiment type: XRAY
Resolution: 1.83 Å
R-factor: 0.218
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bromodomain-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD4, HUNK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60885 (1-End)
      • initiating methionine (0)
    Domains in SCOPe 2.08: d4lysa1, d4lysa2
  • Heterogens: NA, 2SJ, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4lysA (A:)
mnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykiik
tpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqkin
elptee

    Sequence, based on observed residues (ATOM records): (download) 
    >4lysA (A:)
mnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykiik
tpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqkin
elpt