PDB entry 4ly9

View 4ly9 on RCSB PDB site
Description: Human GKRP complexed to AMG-1694 [(2R)-1,1,1-trifluoro-2-{4-[(2S)-2-{[(3S)-3-methylmorpholin-4-yl]methyl}-4-(thiophen-2-ylsulfonyl)piperazin-1-yl]phenyl}propan-2-ol] and sorbitol-6-phosphate
Deposited on 2013-07-30, released 2013-11-20
The last revision was dated 2014-01-15, with a file datestamp of 2014-01-10.
Experiment type: XRAY
Resolution: 2.35 Å
R-factor: 0.217
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: glucokinase regulatory protein
    Species: Homo sapiens [TaxId:9606]
    Gene: gckr
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: glucokinase regulatory protein
    Species: Homo sapiens [TaxId:9606]
    Gene: gckr
    Database cross-references and differences (RAF-indexed):
  • Heterogens: IOD, S6P, 1YY, GOL, SO4, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >4ly9A (A:)
mahhhhhhdevdmpgtkrfqhvietpepgkwelsgyeaavpiteksnpltqdldkadaen
ivrllgqcdaeifqeegqalstyqrlysesilttmvqvagkvqevlkepdgglvvlsggg
tsgrmaflmsvsfnqlmkglgqkplytyliaggdrsvvasregtedsalhgieelkkvaa
gkkrvivigisvglsapfvagqmdccmnntavflpvlvgfnpvsmarndpiedwsstfrq
vaermqkmqekqkafvlnpaigpeglsgssrmkggsatkilletlllaahktvdqgiaas
qrclleilrtferahqvtysqspkiatlmksvstslekkghvylvgwqtlgiiaimdgve
cihtfgadfrdvrgfligdhsdmfnqkaeltnqgpqftfsqedfltsilpslteidtvvf
iftlddnltevqtiveqvkektnhiqalahstvgqtlpiplkklfpsiisitwpllffey
egnfiqkfqrelstkwvlntvstgahvllgkilqnhmldlrisnsklfwralamlqrfsg
qskarciesllraihfpqplsddiraapischvqvahekeqvipiallsllfrcsiteaq
ahlaaapsvceavrsalagpgqkrtadpleilepdvq

    Sequence, based on observed residues (ATOM records):
    >4ly9A (A:)
mpgtkrfqhvietpepgkwelsgyeaavpiteksnpltqdldkadaenivrllgqcdaei
fqeegqstyqrlysesilttmvqvagkvqevlkepdgglvvlsgggtsgrmaflmsvsfn
qlmkglgqkplytyliaggdrsvvasregtedsalhgieelkkvaagkkrvivigisvgl
sapfvagqmdccmnntavflpvlvgfnpvsmarndpiedwsstfrqvaermqkmqekqka
fvlnpaigpeglsgssrmkggsatkilletlllaahktvdqgiaasqrclleilrtfera
hqvtysqspkiatlmksvstslekkghvylvgwqtlgiiaimdgvecihtfgadfrdvrg
fliftfsqedfltsilpslteidtvvfiftlddnltevqtiveqvkektnhiqalahstv
gqtlpiplkklfpsiisitwpllffeyegnfiqkfqrelstkwvlntvstgahvllgkil
qnhmldlrisnsklfwralamlqrfsgqskarciesllraihfpqplsddiraapischv
qvahekeqvipiallsllfrcsiteaqahlaaapsvceavrsala

  • Chain 'B':
    Sequence, based on SEQRES records:
    >4ly9B (B:)
mahhhhhhdevdmpgtkrfqhvietpepgkwelsgyeaavpiteksnpltqdldkadaen
ivrllgqcdaeifqeegqalstyqrlysesilttmvqvagkvqevlkepdgglvvlsggg
tsgrmaflmsvsfnqlmkglgqkplytyliaggdrsvvasregtedsalhgieelkkvaa
gkkrvivigisvglsapfvagqmdccmnntavflpvlvgfnpvsmarndpiedwsstfrq
vaermqkmqekqkafvlnpaigpeglsgssrmkggsatkilletlllaahktvdqgiaas
qrclleilrtferahqvtysqspkiatlmksvstslekkghvylvgwqtlgiiaimdgve
cihtfgadfrdvrgfligdhsdmfnqkaeltnqgpqftfsqedfltsilpslteidtvvf
iftlddnltevqtiveqvkektnhiqalahstvgqtlpiplkklfpsiisitwpllffey
egnfiqkfqrelstkwvlntvstgahvllgkilqnhmldlrisnsklfwralamlqrfsg
qskarciesllraihfpqplsddiraapischvqvahekeqvipiallsllfrcsiteaq
ahlaaapsvceavrsalagpgqkrtadpleilepdvq

    Sequence, based on observed residues (ATOM records):
    >4ly9B (B:)
mpgtkrfqhvietpepgkwelsgyeaavpiteksnpltqdldkadaenivrllgqcdaei
fqeegqstyqrlysesilttmvqvagkvqevlkepdgglvvlsgggtsgrmaflmsvsfn
qlmkglgqkplytyliaggdrsvvasregtedsalhgieelkkvaagkkrvivigisvgl
sapfvagqmdccmnntavflpvlvgfnpvsmarndpiedwsstfrqvaermqkmqekqka
fvlnpaigpeglsgssrmkggsatkilletlllaahktvdqgiaasqrclleilrtfera
hqvtysqspkiatlmksvstslekkghvylvgwqtlgiiaimdgvecihtfgadfrdvrg
fligqgpqftfsqedfltsilpslteidtvvfiftlddnltevqtiveqvkektnhiqal
ahstvgqtlpiplkklfpsiisitwpllffeyegnfiqkfqrelstkwvlntvstgahvl
lgkilqnhmldlrisnsklfwralamlqrfsgqskarciesllraihfpqplsddiraap
ischvqvahekeqvipiallsllfrcsiteaqahlaaapsvceavrsala